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Gene Review

ampD  -  1,6-anhydro-N-acetylmuramyl-L-alanine...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0109, JW0106
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Disease relevance of ampD

  • The ampD genes of Escherichia coli and E. cloacae WT NOR-1 transcomplemented the ceftazidime-resistant E. cloacae NOR-1 mutants to the WT level of beta-lactamase expression, while the mutated ampD alleles of E. cloacae NOR-1 failed to do so [1].
  • Escherichia coli JRG582 is an ampD ampE deletion derivative of strain HfrH and accordingly it is derepressed for expression of the cloned inducible beta-lactamase gene of Citrobacter freundii, carried on plasmid pNU305 [2].

High impact information on ampD

  • In contrast, the ampD mutant accumulates a novel cell wall muropeptide, 1,6-anhydro N-acetylmuramyl-L-alanyl-D-glutamyl-meso-diaminopimelic acid (anhMurNAc-tripeptide), in its cytoplasm [3].
  • Transformation of both ampG and ampD into E. cloacae 55M-L reconstituted the inducible wild-type phenotype [4].
  • Neither the parental phenotype of E. cloacae 55M nor the wild-type phenotype of E. cloacae 55 could be restored in E. cloacae 55M-L by the introduction of functional ampR, ampC, or ampD genes [4].
  • All such revertants demonstrated an inducible wild-type phenotype after introduction of a functional ampD [4].


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