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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ampG  -  muropeptide transporter

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0427, JW0423
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Disease relevance of ampG

  • The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers [1].

High impact information on ampG

  • We have isolated mutants, containing alterations in a novel E. coli gene, ampG, in which a cloned C. freundii ampC gene is unable to respond to beta-lactam inducers [2].
  • We have found that ampG and this ORF form an operon, whose promoter is located in front of the ORF [2].
  • Immediately upstream of ampG there is another 579-base-pair-long open reading frame (ORF) encoding a putative lipoprotein shown to be non-essential for beta-lactamase induction [2].
  • The ampG gene was cloned, sequenced and mapped to minute 9.6 on the E. coli chromosome [2].
  • Transformation of both ampG and ampD into E. cloacae 55M-L reconstituted the inducible wild-type phenotype [3].

Biological context of ampG

  • The nucleotide sequence of all four mutant ampG alleles (ampG1, ampG3, ampG4 and ampG5) was determined [1].
  • These results suggested that the E. cloacae 55M-L phenotype was due to a mutation in an as yet unrecognized gene, designated ampG [3].
  • Additionally it was shown that inactivation of the ampG-like gene irp8 did not affect either Fe-Ybt utilization or mouse virulence [4].

Analytical, diagnostic and therapeutic context of ampG


  1. The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers. Schmidt, H., Korfmann, G., Barth, H., Martin, H.H. Microbiology (Reading, Engl.) (1995) [Pubmed]
  2. AmpG, a signal transducer in chromosomal beta-lactamase induction. Lindquist, S., Weston-Hafer, K., Schmidt, H., Pul, C., Korfmann, G., Erickson, J., Sanders, C., Martin, H.H., Normark, S. Mol. Microbiol. (1993) [Pubmed]
  3. ampG is essential for high-level expression of AmpC beta-lactamase in Enterobacter cloacae. Korfmann, G., Sanders, C.C. Antimicrob. Agents Chemother. (1989) [Pubmed]
  4. Functional analysis of yersiniabactin transport genes of Yersinia enterocolitica. Brem, D., Pelludat, C., Rakin, A., Jacobi, C.A., Heesemann, J. Microbiology (Reading, Engl.) (2001) [Pubmed]
  5. Salmonella enteritidis: AmpC plasmid-mediated inducible beta-lactamase (DHA-1) with an ampR gene from Morganella morganii. Barnaud, G., Arlet, G., Verdet, C., Gaillot, O., Lagrange, P.H., Philippon, A. Antimicrob. Agents Chemother. (1998) [Pubmed]
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