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Gene Review

ampC  -  penicillin-binding protein; beta-lactamase...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4146, JW4111, ampA
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Disease relevance of ampC


High impact information on ampC


Chemical compound and disease context of ampC


Biological context of ampC


Associations of ampC with chemical compounds


Other interactions of ampC


Analytical, diagnostic and therapeutic context of ampC


  1. ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type. Jaurin, B., Grundström, T. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  2. Comparison of the overlapping frd and ampC operons of Escherichia coli with the corresponding DNA sequences in other gram-negative bacteria. Bergström, S., Lindberg, F.P., Olsson, O., Normark, S. J. Bacteriol. (1983) [Pubmed]
  3. ampC beta-lactamase hyperproduction in Escherichia coli: natural ampicillin resistance generated by horizontal chromosomal DNA transfer from Shigella. Olsson, O., Bergström, S., Lindberg, F.P., Normark, S. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  4. Signalling proteins in enterobacterial AmpC beta-lactamase regulation. Lindquist, S., Galleni, M., Lindberg, F., Normark, S. Mol. Microbiol. (1989) [Pubmed]
  5. Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria. Jacobs, C., Frère, J.M., Normark, S. Cell (1997) [Pubmed]
  6. Insertion of IS2 creates a novel ampC promoter in Escherichia coli. Jaurin, B., Normark, S. Cell (1983) [Pubmed]
  7. Increase in ampC promoter strength due to mutations and deletion of the attenuator in a clinical isolate of cefoxitin-resistant Escherichia coli as determined by RT-PCR. Tracz, D.M., Boyd, D.A., Bryden, L., Hizon, R., Giercke, S., Van Caeseele, P., Mulvey, M.R. J. Antimicrob. Chemother. (2005) [Pubmed]
  8. AmpC and AmpH, proteins related to the class C beta-lactamases, bind penicillin and contribute to the normal morphology of Escherichia coli. Henderson, T.A., Young, K.D., Denome, S.A., Elf, P.K. J. Bacteriol. (1997) [Pubmed]
  9. Extension of resistance to cefepime and cefpirome associated to a six amino acid deletion in the H-10 helix of the cephalosporinase of an Enterobacter cloacae clinical isolate. Barnaud, G., Labia, R., Raskine, L., Sanson-Le Pors, M.J., Philippon, A., Arlet, G. FEMS Microbiol. Lett. (2001) [Pubmed]
  10. Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli. Nelson, E.C., Elisha, B.G. Antimicrob. Agents Chemother. (1999) [Pubmed]
  11. Overlap between ampC and frd operons on the Escherichia coli chromosome. Grundström, T., Jaurin, B. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  12. Characterisation of CTX-M and AmpC genes in human isolates of Escherichia coli identified between 1995 and 2003 in England and Wales. Hopkins, K.L., Batchelor, M.J., Liebana, E., Deheer-Graham, A.P., Threlfall, E.J. Int. J. Antimicrob. Agents (2006) [Pubmed]
  13. AmpG, a signal transducer in chromosomal beta-lactamase induction. Lindquist, S., Weston-Hafer, K., Schmidt, H., Pul, C., Korfmann, G., Erickson, J., Sanders, C., Martin, H.H., Normark, S. Mol. Microbiol. (1993) [Pubmed]
  14. Inducible cephalosporinase production in clinical isolates of Enterobacter cloacae is controlled by a regulatory gene that has been deleted from Escherichia coli. Honoré, N., Nicolas, M.H., Cole, S.T. EMBO J. (1986) [Pubmed]
  15. Stationary phase expression of a novel Escherichia coli outer membrane lipoprotein and its relationship with mammalian apolipoprotein D. Implications for the origin of lipocalins. Bishop, R.E., Penfold, S.S., Frost, L.S., Höltje, J.V., Weiner, J.H. J. Biol. Chem. (1995) [Pubmed]
  16. ampG is essential for high-level expression of AmpC beta-lactamase in Enterobacter cloacae. Korfmann, G., Sanders, C.C. Antimicrob. Agents Chemother. (1989) [Pubmed]
  17. Molecular characterization of cefoxitin-resistant Escherichia coli from Canadian hospitals. Mulvey, M.R., Bryce, E., Boyd, D.A., Ofner-Agostini, M., Land, A.M., Simor, A.E., Paton, S. Antimicrob. Agents Chemother. (2005) [Pubmed]
  18. Patterns and mechanisms of resistance to beta-lactams and beta-lactamase inhibitors in uropathogenic Escherichia coli isolated from dogs in Portugal. Féria, C., Ferreira, E., Correia, J.D., Gonçalves, J., Caniça, M. J. Antimicrob. Chemother. (2002) [Pubmed]
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