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Gene Review

osmC  -  lipoyl-dependent Cys-based peroxidase,...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1476, JW1477
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Disease relevance of osmC

  • Growth-phase-dependent expression of the osmotically inducible gene osmC of Escherichia coli K-12 [1].
  • One of two osmC homologs in Bacillus subtilis is part of the sigmaB-dependent general stress regulon [2].
  • To determine if these two subfamilies are functionally distinct, ohr and osmC in Pseudomonas aeruginosa (a bacterium with one representative from each subfamily) were analysed [3].

High impact information on osmC

  • We find that RprA synthesis is regulated by the RcsC/RcsB phosphorelay system, previously found to regulate capsule synthesis and promoters of ftsZ and osmC [4].
  • Yet, under our experimental conditions, the subsequent expression of the osmC-lacZ fusion was equivalent to that obtained from the tandem promoters [5].
  • The sequence of an osmC-phoA gene fusion confirmed the osmC reading frame [5].
  • The expression of this operon fusion demonstrated that osmC regulation occurs at the transcriptional level [5].
  • A deletion of osmC from the E. coli chromosome was constructed by gene replacement, demonstrating that it is not an essential gene [5].

Biological context of osmC

  • All the sequences necessary for osmotic regulation of both promoters are located within a 137 base-pair DNA fragment extending from position -95 to +42 with respect to the putative osmC translation start [5].
  • Only ohr mutants are hypersensitive to organic peroxide, and this phenotype can be restored by complementation with ohr but not osmC [3].
  • Mutants in osmC, a member of the rpoS regulon, also exhibited reduced survival and increased sensitivity to oxidative stress [6].
  • The osmCp promoter region was subcloned and a lac operon fusion transcribed under osmCp control was constructed [5].

Associations of osmC with chemical compounds


Analytical, diagnostic and therapeutic context of osmC


  1. Growth-phase-dependent expression of the osmotically inducible gene osmC of Escherichia coli K-12. Gordia, S., Gutierrez, C. Mol. Microbiol. (1996) [Pubmed]
  2. One of two osmC homologs in Bacillus subtilis is part of the sigmaB-dependent general stress regulon. Völker, U., Andersen, K.K., Antelmann, H., Devine, K.M., Hecker, M. J. Bacteriol. (1998) [Pubmed]
  3. Bacterial Ohr and OsmC paralogues define two protein families with distinct functions and patterns of expression. Atichartpongkul, S., Loprasert, S., Vattanaviboon, P., Whangsuk, W., Helmann, J.D., Mongkolsuk, S. Microbiology (Reading, Engl.) (2001) [Pubmed]
  4. Regulation and mode of action of the second small RNA activator of RpoS translation, RprA. Majdalani, N., Hernandez, D., Gottesman, S. Mol. Microbiol. (2002) [Pubmed]
  5. Osmotic induction of gene osmC expression in Escherichia coli K12. Gutierrez, C., Devedjian, J.C. J. Mol. Biol. (1991) [Pubmed]
  6. Survival of Escherichia coli during long-term starvation: effects of aeration, NaCl, and the rpoS and osmC gene products. Conter, A., Gangneux, C., Suzanne, M., Gutierrez, C. Res. Microbiol. (2001) [Pubmed]
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