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Gene Review:

NS2 - nonstructural protein NS-2

Influenza B virus

Briedis, D.J. et al., Akarsu, H. et al., Tanaka, T. et al.

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Disease relevance of NS2

Influenza B virus genome: sequences and structural organization of RNA segment 8 and the mRNAs coding for the NS1 and NS2 proteins [1].
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2) [2].

High impact information on NS2

Nuclear export is mediated by the cellular protein Crm1 and putatively by the viral protein NEP/NS2 [2].
The first approximately 75 virus-specific nucleotides at the 5' end of the NS2 mRNA are the same as are found at the 5' -end of the NS1 mRNA [1].

Biological context of NS2

The approximately 350-nucleotide body region of the NS2 mRNA can be translated in the +1 reading frame, and the sequence indicates that the NS1 and NS2 protein-coding regions overlap by 52 amino acids translated from different reading frames [1].

Analytical, diagnostic and therapeutic context of NS2

Peptide mapping revealed that NS of clone 201 was structurally different from either NS1 or NS2 of wild-type B/Yamagata [3].

References

Influenza B virus genome: sequences and structural organization of RNA segment 8 and the mRNAs coding for the NS1 and NS2 proteins. Briedis, D.J., Lamb, R.A. J. Virol. (1982) [Pubmed]
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2). Akarsu, H., Burmeister, W.P., Petosa, C., Petit, I., Müller, C.W., Ruigrok, R.W., Baudin, F. EMBO J. (2003) [Pubmed]
Isolation and preliminary characterization of a highly cytolytic influenza B virus variant with an aberrant NS gene. Tanaka, T., Urabe, M., Goto, H., Tobita, K. Virology (1984) [Pubmed]

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