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Gene Review

NS1  -  nonstructural protein NS-1

Influenza B virus

 
 
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Disease relevance of NS1

  • Influenza B virus genome: sequences and structural organization of RNA segment 8 and the mRNAs coding for the NS1 and NS2 proteins [1].
  • Interaction cloning of NS1-I, a human protein that binds to the nonstructural NS1 proteins of influenza A and B viruses [2].
  • The fact that influenza A and influenza B virus NS1 proteins bind to NS1-I suggests that this cellular protein plays a role in the influenza virus life cycle [2].
  • The yeast interaction trap system was used to identify, NS1-I (for NS1 interactor), which is a human protein that binds to the nonstructural NS1 protein of the influenza A virus [2].
  • The major virus-specific proteins (HA, NA, NP, NS1 and M) of five different isolates of influenza B virus (B/Lee/40, B/Osaka/2/70, B/Yamagata/1/73, B/Aomori/1/76 and B/Yamagata/26/77) were compared by limited proteolysis with Staphylococcus aureus V8 protease and subsequent polyacrylamide gel electrophoresis [3].
 

High impact information on NS1

  • We previously demonstrated that efficient replication of influenza B virus depends on the viral dsRNA-binding NS1 protein that inhibits the transcriptional activation of IFN-alpha/beta genes [4].
  • Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta Interferon [4].
  • The first approximately 75 virus-specific nucleotides at the 5' end of the NS2 mRNA are the same as are found at the 5' -end of the NS1 mRNA [1].
  • Structural basis for ubiquitin-like ISG 15 protein binding to the NS1 protein of influenza B virus: a protein-protein interaction function that is not shared by the corresponding N-terminal domain of the NS1 protein of influenza A virus [5].
  • Nucleotide sequence and some biological properties of the NS gene of a newly isolated influenza B virus mutant which has a long carboxyl terminal deletion in the NS1 protein [6].
 

Biological context of NS1

 

Other interactions of NS1

  • The nucleoproteins (NP) as well as the non-structural proteins (NS1) were also very similar among strains although the peptides of B/Lee/40 could be distinguished from those of the strains isolated from 1970 to 1977 [3].
 

Analytical, diagnostic and therapeutic context of NS1

  • Peptide mapping revealed that NS of clone 201 was structurally different from either NS1 or NS2 of wild-type B/Yamagata [7].
  • Sequence analysis of the NS gene of this virus revealed a 10 nucleotide deletion resulting in an NS1 protein of only 124 amino acids [8].
  • This truncated NS1 polypeptide retained its karyophilic pattern as detected by indirect immunofluorescence analysis of virus infected cells [8].

References

  1. Influenza B virus genome: sequences and structural organization of RNA segment 8 and the mRNAs coding for the NS1 and NS2 proteins. Briedis, D.J., Lamb, R.A. J. Virol. (1982) [Pubmed]
  2. Interaction cloning of NS1-I, a human protein that binds to the nonstructural NS1 proteins of influenza A and B viruses. Wolff, T., O'Neill, R.E., Palese, P. J. Virol. (1996) [Pubmed]
  3. A comparison of proteins among various influenza B virus strains by one-dimensional peptide mapping. Nakamura, K., Kitame, F., Homma, M. J. Gen. Virol. (1981) [Pubmed]
  4. Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta Interferon. Dauber, B., Schneider, J., Wolff, T. J. Virol. (2006) [Pubmed]
  5. Structural basis for ubiquitin-like ISG 15 protein binding to the NS1 protein of influenza B virus: a protein-protein interaction function that is not shared by the corresponding N-terminal domain of the NS1 protein of influenza A virus. Yuan, W., Aramini, J.M., Montelione, G.T., Krug, R.M. Virology (2002) [Pubmed]
  6. Nucleotide sequence and some biological properties of the NS gene of a newly isolated influenza B virus mutant which has a long carboxyl terminal deletion in the NS1 protein. Tobita, K., Tanaka, T., Odagiri, T., Tashiro, M., Feng, S.Y. Virology (1990) [Pubmed]
  7. Isolation and preliminary characterization of a highly cytolytic influenza B virus variant with an aberrant NS gene. Tanaka, T., Urabe, M., Goto, H., Tobita, K. Virology (1984) [Pubmed]
  8. Infectious influenza A and B virus variants with long carboxyl terminal deletions in the NS1 polypeptides. Norton, G.P., Tanaka, T., Tobita, K., Nakada, S., Buonagurio, D.A., Greenspan, D., Krystal, M., Palese, P. Virology (1987) [Pubmed]
 
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