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Gene Review

ptr  -  protease III

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of ptr

  • Analysis of the cloned protease III gene (ptr) from Escherichia coli K-12 has demonstrated that in addition to the previously characterized 110,000-Mr protease III protein, a second 50,000-Mr polypeptide (p50) is derived from the amino-terminal end of the coding sequence [1].
  • Nalidixic acid, novobiocin and coumermycin specifically inhibit phage promoter-dependent transcription of the trp operon in phi 80 ptrp but not transcription from the authentic trp promoter [2].
 

High impact information on ptr

  • Extensive attempts were made to overexpress the Escherichia coli haemolysin translocator protein HlyB, and HlyB fragments, utilising high copy number plasmids or hlyB expressed from strong promoters including lambda PR, ptrp and the T7 promoter [3].
 

Chemical compound and disease context of ptr

 

Biological context of ptr

  • Escherichia coli strains carrying the protease III structural gene (ptr) on a plasmid secreted the protein into the growth medium [5].

References

 
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