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Gene Review

infA  -  translation initiation factor IF-1

Escherichia coli O157:H7 str. EDL933

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Disease relevance of infA


High impact information on infA


Chemical compound and disease context of infA

  • Starting from a synthetic modular gene (infA) encoding Escherichia coli translation initiation factor IF1, we have constructed mutants in which amino acids are deleted from the carboxyl terminus or in which His29 or His34 are replaced by Tyr or Asp residues [5].

Anatomical context of infA


Associations of infA with chemical compounds

  • The purpose of our study was to examine the expression of a cluster of genes that are required for translation in C. trachomatis serovar F: infA (encoding Initiation Factor 1), tRNA(Thr), tuf (encoding Elongation Factor Tu), and tRNA(Trp) [7].

Analytical, diagnostic and therapeutic context of infA


  1. Translation initiation factor IF1 is essential for cell viability in Escherichia coli. Cummings, H.S., Hershey, J.W. J. Bacteriol. (1994) [Pubmed]
  2. Differential promoter usage of infA in response to cold shock in Escherichia coli. Ko, J.H., Lee, S.J., Cho, B., Lee, Y. FEBS Lett. (2006) [Pubmed]
  3. SigmaS-dependent gene expression at the onset of stationary phase in Escherichia coli: function of sigmaS-dependent genes and identification of their promoter sequences. Lacour, S., Landini, P. J. Bacteriol. (2004) [Pubmed]
  4. Generation and characterization of functional mutants in the translation initiation factor IF1 of Escherichia coli. Croitoru, V., Bucheli-Witschel, M., Hägg, P., Abdulkarim, F., Isaksson, L.A. Eur. J. Biochem. (2004) [Pubmed]
  5. Site-directed mutagenesis of Escherichia coli translation initiation factor IF1. Identification of the amino acid involved in its ribosomal binding and recycling. Gualerzi, C.O., Spurio, R., La Teana, A., Calogero, R., Celano, B., Pon, C.L. Protein Eng. (1989) [Pubmed]
  6. Interaction of Escherichia coli translation-initiation factor IF-1 with ribosomes. Celano, B., Pawlik, R.T., Gualerzi, C.O. Eur. J. Biochem. (1988) [Pubmed]
  7. Identification and characterization of promoters regulating tuf expression in Chlamydia trachomatis serovar F. Shen, L., Shi, Y., Douglas, A.L., Hatch, T.P., O'Connell, C.M., Chen, J.M., Zhang, Y.X. Arch. Biochem. Biophys. (2000) [Pubmed]
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