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Gene Review

WTAP  -  Wilms tumor 1 associated protein

Homo sapiens

Synonyms: Female-lethal(2)D homolog, KIAA0105, MGC3925, Mum2, Pre-mRNA-splicing regulator WTAP, ...
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Disease relevance of WTAP


High impact information on WTAP

  • Collectively, these findings establish WTAP as an essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G(2)/M cell-cycle transition [2].
  • Wilms' tumor 1-associating protein (WTAP) has been reported to be a ubiquitously expressed nuclear protein [2].
  • To investigate the role of WTAP, we generated WTAP-knockout mice and performed small interfering RNA (siRNA)-mediated knockdown analyses in primary cultured cells [2].
  • We report the identification of a novel human WT1-associating protein, WTAP, which was isolated using the yeast two-hybrid system [3].
  • On the other hand, the cells expressing mutant (MT) APP or coexpressing WTAPP and MTPS1/2 produced a greater proportion of AICD-(49-99) than AICD-(50-99) [4].

Biological context of WTAP

  • Introduction of WTAP complementary DNA into human SMCs inhibited their proliferation, with a corresponding decrease in DNA synthesis and an increase in apoptosis [5].
  • These findings identify WTAP as a novel regulator of the cell cycle and cell survival and implicate a WTAP-WT1 axis as a novel pathway for controlling vascular SMC phenotype [5].

Physical interactions of WTAP

  • Interestingly, this gene encodes a protein (WTAP) that was previously found to interact with the Wilms' tumor suppressor-1 (WT1), an isoform of which binds to and co-localizes with splicing factors [6].


  1. Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias. Utsch, B., Kaya, A., Ozburun, A., Lentze, M.J., Albers, N., Ludwig, M. Scandinavian journal of urology and nephrology. (2003) [Pubmed]
  2. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Horiuchi, K., Umetani, M., Minami, T., Okayama, H., Takada, S., Yamamoto, M., Aburatani, H., Reid, P.C., Housman, D.E., Hamakubo, T., Kodama, T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Identification of WTAP, a novel Wilms' tumour 1-associating protein. Little, N.A., Hastie, N.D., Davies, R.C. Hum. Mol. Genet. (2000) [Pubmed]
  4. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. Kakuda, N., Funamoto, S., Yagishita, S., Takami, M., Osawa, S., Dohmae, N., Ihara, Y. J. Biol. Chem. (2006) [Pubmed]
  5. Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. Small, T.W., Bolender, Z., Bueno, C., O'Neil, C., Nong, Z., Rushlow, W., Rajakumar, N., Kandel, C., Strong, J., Madrenas, J., Pickering, J.G. Circ. Res. (2006) [Pubmed]
  6. Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing. Ortega, A., Niksic, M., Bachi, A., Wilm, M., Sánchez, L., Hastie, N., Valcárcel, J. J. Biol. Chem. (2003) [Pubmed]
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