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Gene Review

bcr  -  bicyclomycin/multidrug efflux system protein

Escherichia coli O157:H7 str. EDL933

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Disease relevance of bcr


High impact information on bcr

  • It contained several splice junctions conserved with the sequence-related protein kinase C and bcr genes. alpha 2-Chimerin is only the second SH2-containing GAP and the first example of an SH2 domain generated by alternate splicing [3].
  • The activity of tigecycline, 9-(t-butylglycylamido)-minocycline, against Escherichia coli KAM3 (acrB) strains harboring plasmids encoding various tetracycline-specific efflux transporter genes, tet(B), tet(C), and tet(K), and multidrug transporter genes, acrAB, acrEF, and bcr, was examined [4].
  • A reporter gene assay suggested that the bcr gene is constitutively expressed at a substantial level [1].


  1. Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli. Yamada, S., Awano, N., Inubushi, K., Maeda, E., Nakamori, S., Nishino, K., Yamaguchi, A., Takagi, H. Appl. Environ. Microbiol. (2006) [Pubmed]
  2. The role of the bacitracin ABC transporter in bacitracin resistance and collateral detergent sensitivity. Podlesek, Z., Comino, A., Herzog-Velikonja, B., Grabnar, M. FEMS Microbiol. Lett. (2000) [Pubmed]
  3. Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. Hall, C., Sin, W.C., Teo, M., Michael, G.J., Smith, P., Dong, J.M., Lim, H.H., Manser, E., Spurr, N.K., Jones, T.A. Mol. Cell. Biol. (1993) [Pubmed]
  4. Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936). Hirata, T., Saito, A., Nishino, K., Tamura, N., Yamaguchi, A. Antimicrob. Agents Chemother. (2004) [Pubmed]
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