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Gene Review:

bcr - bicyclomycin/multidrug efflux system protein

Escherichia coli O157:H7 str. EDL933

Yamada, S. et al., Hirata, T. et al., Hall, C. et al., Podlesek, Z. et al.

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Disease relevance of bcr

When a tnaA-disrupted E. coli strain expressing the altered cysE gene was transformed with a plasmid carrying the bcr gene, the transformant exhibited more L-cysteine production than cells carrying the vector only [1].
Bacillus subtilis cells carrying bcr genes on high-copy number plasmids developed collateral detergent sensitivity, as did human cells with overexpressed multidrug resistance P-glycoprotein [2].

High impact information on bcr

It contained several splice junctions conserved with the sequence-related protein kinase C and bcr genes. alpha 2-Chimerin is only the second SH2-containing GAP and the first example of an SH2 domain generated by alternate splicing [3].
The activity of tigecycline, 9-(t-butylglycylamido)-minocycline, against Escherichia coli KAM3 (acrB) strains harboring plasmids encoding various tetracycline-specific efflux transporter genes, tet(B), tet(C), and tet(K), and multidrug transporter genes, acrAB, acrEF, and bcr, was examined [4].
A reporter gene assay suggested that the bcr gene is constitutively expressed at a substantial level [1].

References

Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli. Yamada, S., Awano, N., Inubushi, K., Maeda, E., Nakamori, S., Nishino, K., Yamaguchi, A., Takagi, H. Appl. Environ. Microbiol. (2006) [Pubmed]
The role of the bacitracin ABC transporter in bacitracin resistance and collateral detergent sensitivity. Podlesek, Z., Comino, A., Herzog-Velikonja, B., Grabnar, M. FEMS Microbiol. Lett. (2000) [Pubmed]
Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. Hall, C., Sin, W.C., Teo, M., Michael, G.J., Smith, P., Dong, J.M., Lim, H.H., Manser, E., Spurr, N.K., Jones, T.A. Mol. Cell. Biol. (1993) [Pubmed]
Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936). Hirata, T., Saito, A., Nishino, K., Tamura, N., Yamaguchi, A. Antimicrob. Agents Chemother. (2004) [Pubmed]

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