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Gene Review

SAFB2  -  scaffold attachment factor B2

Homo sapiens

Synonyms: KIAA0138, SAF-B2, Scaffold attachment factor B2
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Disease relevance of SAFB2


High impact information on SAFB2

  • They are coexpressed in a number of tissues, but unlike SAFB1, which is exclusively nuclear, SAFB2 is found in the cytoplasm as well as the nucleus [2].
  • As shown previously for SAFB1, SAFB2 functions as an estrogen receptor corepressor, and its overexpression results in inhibition of proliferation [2].
  • Consistent with its cytoplasmic localization, we detected an interaction between SAFB2 and vinexin, a protein involved in linking signaling to the cytoskeleton [2].
  • SAFB1 and SAFB2 are mapped adjacent to each other on chromosome 19p13.3 and are arranged in a bidirectional divergent configuration (head to head), being separated by a short (<500 bp) GC-rich intergenic region that can function as a bidirectional promoter [2].
  • Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2 [3].

Biological context of SAFB2


Anatomical context of SAFB2

  • Using novel mono-specific antisera, we found endogenous SAFB2 protein has a different spatial distribution from SAFB1 within the nucleus where it is found in much larger nuclear complexes (up to 670 kDa in size), and a distinct pattern of expression in adult human testis [3].

Other interactions of SAFB2


  1. Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis? Oesterreich, S. J. Cell. Biochem. (2003) [Pubmed]
  2. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. Townson, S.M., Dobrzycka, K.M., Lee, A.V., Air, M., Deng, W., Kang, K., Jiang, S., Kioka, N., Michaelis, K., Oesterreich, S. J. Biol. Chem. (2003) [Pubmed]
  3. Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2. Sergeant, K.A., Bourgeois, C.F., Dalgliesh, C., Venables, J.P., Stevenin, J., Elliott, D.J. J. Cell. Sci. (2007) [Pubmed]
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