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Gene Review

SORBS3  -  sorbin and SH3 domain containing 3

Homo sapiens

Synonyms: SCAM-1, SCAM1, SH3-containing adapter molecule 1, SH3D4, Sorbin and SH3 domain-containing protein 3, ...
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Disease relevance of SORBS3

  • Differential expression of vinexin-beta in lesions with a thrombus compared to stable plaques could not be confirmed, indicating the importance of validation of proteomic analysis [1].
  • Theories like the belief that HIV is a harmless virus or does not exist (making precautions unnecessary), that AIDS is caused by the drugs used to treat it, or that the whole epidemic is a scam to sell pills and collect research grants, need better response from the medical, scientific, service, and activist communities [2].

Psychiatry related information on SORBS3

  • The fear of dealing with a patient who is "running a scam" to obtain prescription drugs, or the anxiety of having to deal with an overly zealous DEA agent, further complicates the physician's role in the care of these parties [3].

High impact information on SORBS3


Biological context of SORBS3

  • Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction [9].
  • On the other hand, the phosphorylation was hardly detected in neurons cultured for 3 days, suggesting the presence of a yet unidentified regulatory mechanism of vinexin at the growth cone [10].
  • Vinexin is an adaptor protein that is supposed to play pivotal roles in cell adhesion, cytoskeletal organization and signaling [10].
  • Cysteine-scanning mutagenesis (SCAM) and computer-based modeling were used to investigate key structural features of the S6 transmembrane segment of the calcium-activated K(+) channel of intermediate conductance IKCa [11].

Anatomical context of SORBS3


Associations of SORBS3 with chemical compounds

  • Our SCAM results show that the interaction of [2-(trimethylammonium)ethyl] methanethiosulfonate bromide (MTSET) with cysteines engineered at positions 275, 278, and 282 leads to current inhibition [11].

Regulatory relationships of SORBS3


Other interactions of SORBS3


Analytical, diagnostic and therapeutic context of SORBS3

  • Nerve terminal localization of vinexin was confirmed by electron microscopy [10].
  • FDA petitioned to 'stop homeopathy scam' [14].
  • Immunohistochemistry and western blotting showed limited expression of both vinexin-beta and AAT in early lesions, whereas high expression of both proteins was found in advanced lesions [1].
  • Whatever the final answer turns out to be, the genetic dissection of the SCAM superfamilies has led to a much better understanding of the different steps required to form, differentiate and modify a synapse [15].
  • Using the Xenopus oocyte expression system and the SCAM (substituted cysteine accessibility method), we found that M3 segments of both NR1 and NR3A form a narrow constriction in the outer vestibule of the channel, which prevents passage of externally applied sulfhydryl-specific agents [16].


  1. Proteomic analysis of differential protein expression in human atherosclerotic plaque progression. Donners, M.M., Verluyten, M.J., Bouwman, F.G., Mariman, E.C., Devreese, B., Vanrobaeys, F., van Beeumen, J., van den Akker, L.H., Daemen, M.J., Heeneman, S. J. Pathol. (2005) [Pubmed]
  2. AIDS denialists: how to respond. James, J.S. AIDS treatment news. (2000) [Pubmed]
  3. Pain management in the chemically dependent patient. Hicks, R.D. Hawaii medical journal. (1989) [Pubmed]
  4. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. Kimura, A., Baumann, C.A., Chiang, S.H., Saltiel, A.R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. Townson, S.M., Dobrzycka, K.M., Lee, A.V., Air, M., Deng, W., Kang, K., Jiang, S., Kioka, N., Michaelis, K., Oesterreich, S. J. Biol. Chem. (2003) [Pubmed]
  6. A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins. Hirao, K., Hata, Y., Ide, N., Takeuchi, M., Irie, M., Yao, I., Deguchi, M., Toyoda, A., Sudhof, T.C., Takai, Y. J. Biol. Chem. (1998) [Pubmed]
  7. SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. Reif, K., Buday, L., Downward, J., Cantrell, D.A. J. Biol. Chem. (1994) [Pubmed]
  8. The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. Martens, N., Wery, M., Wang, P., Braet, F., Gertler, A., Hooghe, R., Vandenhaute, J., Hooghe-Peters, E.L. Exp. Cell Res. (2004) [Pubmed]
  9. Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction. Kioka, N., Ueda, K., Amachi, T. Cell Struct. Funct. (2002) [Pubmed]
  10. Phosphorylation by extracellular signal-regulated kinase of a multidomain adaptor protein, vinexin, at synapses. Ito, H., Usuda, N., Atsuzawa, K., Iwamoto, I., Sudo, K., Katoh-Semba, R., Mizutani, K., Morishita, R., Deguchi, T., Nozawa, Y., Asano, T., Nagata, K. J. Neurochem. (2007) [Pubmed]
  11. Cysteine mutagenesis and computer modeling of the S6 region of an intermediate conductance IKCa channel. Simoes, M., Garneau, L., Klein, H., Banderali, U., Hobeila, F., Roux, B., Parent, L., Sauvé, R. J. Gen. Physiol. (2002) [Pubmed]
  12. Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. Mitsushima, M., Ueda, K., Kioka, N. Genes Cells (2006) [Pubmed]
  13. Analysis of gene expression profiles of hepatocellular carcinomas with regard to 18F-fluorodeoxyglucose uptake pattern on positron emission tomography. Lee, J.D., Yun, M., Lee, J.M., Choi, Y., Choi, Y.H., Kim, J.S., Kim, S.J., Kim, K.S., Yang, W.I., Park, Y.N., Han, K.H., Lee, W.J., Yoo, N., Lim, S.M., Park, J.H. Eur. J. Nucl. Med. Mol. Imaging (2004) [Pubmed]
  14. FDA petitioned to 'stop homeopathy scam'. Skolnick, A.A. JAMA (1994) [Pubmed]
  15. The resilient synapse: insights from genetic interference of synaptic cell adhesion molecules. Piechotta, K., Dudanova, I., Missler, M. Cell Tissue Res. (2006) [Pubmed]
  16. NR3A modulates the outer vestibule of the "NMDA" receptor channel. Wada, A., Takahashi, H., Lipton, S.A., Chen, H.S. J. Neurosci. (2006) [Pubmed]
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