High impact information on PLEKHM1

• Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages [1].
• The tissue distribution of mRNA in T. rubripes is similar for B1 and B2, suggesting more similar regulation for the two genes than in mammals [1].
• All of these species have two receptor genes located close to each other in a tandem formation, with the B2 gene 5' to the B1 gene, in chromosomal regions displaying conserved synteny between the species (albeit conservation of synteny in zebrafish is still unclear due to poor genome assembly) [1].
• The expression of the recombinant B2-protein enhanced staurosporine-induced apoptosis in epithelial cancer cell lines [2].
• Novel adapter protein AP162 connects a sialyl-Le(x)-positive mucin with an apoptotic signal transduction pathway [2].

Associations of PLEKHM1 with chemical compounds

• Monospecific antibodies against the B2-protein precipitated from the solubilised membrane fraction of the colon carcinoma cell line LS 174T a protein with an apparent Mr = 162 kDa and, additionally, a mucin-like glycoprotein with an apparent Mr = 220 kDa [2].

Other interactions of PLEKHM1

• The B2 protein exhibited two putative PH (pleckstrin homology) domains and a leucine zipper motif but no homology to any known proteins [2].

References