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Gene Review

cadA  -  cadmium resistance protein

Listeria monocytogenes EGD-e

 
 
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Disease relevance of cadA

 

High impact information on cadA

  • Restriction analysis and Southern hybridization revealed the presence of Tn5422 in all the plasmid-mediated cadmium-resistant L. monocytogenes strains tested but not in strains encoding cadmium resistance on the chromosome [1].
  • It contains two genes which confer cadmium resistance (M. Lebrun, A. Audurier, and P. Cossart, J. Bacteriol. 176:3040-3048, 1994) and two open reading frames that encode a transposase (TnpA) and a resolvase (TnpR) of 971 and 184 amino acids, respectively [1].
 

Biological context of cadA

References

  1. Plasmid-borne cadmium resistance genes in Listeria monocytogenes are present on Tn5422, a novel transposon closely related to Tn917. Lebrun, M., Audurier, A., Cossart, P. J. Bacteriol. (1994) [Pubmed]
  2. Genetic characterization of the fusidic acid and cadmium resistance determinants of Staphylococcus aureus plasmid pUB101. O'Brien, F.G., Price, C., Grubb, W.B., Gustafson, J.E. J. Antimicrob. Chemother. (2002) [Pubmed]
  3. Plasmid-borne cadmium resistance genes in Listeria monocytogenes are similar to cadA and cadC of Staphylococcus aureus and are induced by cadmium. Lebrun, M., Audurier, A., Cossart, P. J. Bacteriol. (1994) [Pubmed]
  4. Genetic analysis of regions involved in replication and cadmium resistance of the plasmid pND302 from Lactococcus lactis. Liu, C.Q., Khunajakr, N., Chia, L.G., Deng, Y.M., Charoenchai, P., Dunn, N.W. Plasmid (1997) [Pubmed]
  5. Plasmids in Listeria monocytogenes in relation to cadmium resistance. Lebrun, M., Loulergue, J., Chaslus-Dancla, E., Audurier, A. Appl. Environ. Microbiol. (1992) [Pubmed]
 
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