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Gene Review:

TOMM70A - translocase of outer mitochondrial...

Homo sapiens

Synonyms: KIAA0719, Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, TOM70, Translocase of outer membrane 70 kDa subunit

Alvarez-Dolado, M. et al., Edmonson, A.M. et al.

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High impact information on TOMM70A

S2 was identified as KIAA0719, the first human gene distantly homologous to the fungal Tom70, which encodes a member of the translocase mitochondrial outer membrane complex involved in the import of preproteins into the mitochondria [1].
Thus, KIAA0719 gene expression is regulated by thyroid hormone in the neonatal rat brain in a region-specific fashion [1].
Significantly, treatment of hypothyroid animals with single injections of thyroxine restored the normal levels of KIAA0719 expression [1].
By northern and in situ hybridization studies, KIAA0719 was found to be up-regulated in the striatum, nucleus accumbens, and discrete cortical layers of 15-day-old hypothyroid rats [1].
TOMM70A localizes in the mitochondria of COS-7 cells, and in organello import assays confirmed its presence in the Outer Mitochondrial membrane (OM) of rat liver mitochondria [2].

Biological context of TOMM70A

TOMM70A is ubiquitously expressed in human tissues, maps on chromosome 3q13.1-q13.2 and consists of 12 coding exons spanning over 37 kb [2].

References

Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. Alvarez-Dolado, M., González-Moreno, M., Valencia, A., Zenke, M., Bernal, J., Muñoz, A. J. Neurochem. (1999) [Pubmed]
Characterization of a human import component of the mitochondrial outer membrane, TOMM70A. Edmonson, A.M., Mayfield, D.K., Vervoort, V., DuPont, B.R., Argyropoulos, G. Cell Commun. Adhes. (2002) [Pubmed]

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AgaP_AGAP009497	Anopheles gambiae str. PEST
AGOS_ABR131W	Ashbya gossypii ATCC 10895
TOMM70A	Bos taurus
TOMM70A	Canis lupus familiaris
tomm70a	Danio rerio
Tom70	Drosophila melanogaster
TOMM70A	Gallus gallus
KLLA0F24046g	Kluyveromyces lactis NRRL Y-1140
TOMM70A	Macaca mulatta
MGG_00979	Magnaporthe oryzae 70-15
Tomm70a	Mus musculus
NCU04245	Neurospora crassa OR74A
TOMM70A	Pan troglodytes
Tomm70a	Rattus norvegicus
TOM70	Saccharomyces cerevisiae S288c
tom70	Schizosaccharomyces pombe 972h-
tomm70a	Xenopus (Silurana) tropicalis

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