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Gene Review

RHOBTB1  -  Rho-related BTB domain containing 1

Homo sapiens

Synonyms: KIAA0740, Rho-related BTB domain-containing protein 1
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Disease relevance of RHOBTB1


High impact information on RHOBTB1

  • The biological roles of RHOBTB proteins, including DBC2, remain unclear [2].
  • RHOBTB1 (located on chromosome 10) and RHOBTB3 (located on chromosome 5) appear ubiquitously expressed [3].
  • RHOBTB2 (located on chromosome 8) showed much lower levels of expression than the other two human RHOBTB genes and it was most abundant in neural tissues [3].
  • RHOBTB genes are upregulated in some cancer cell lines, suggesting that these proteins might participate in tumorigenesis [3].
  • CONCLUSION: Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC [1].

Biological context of RHOBTB1


Anatomical context of RHOBTB1


  1. Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. Beder, L.B., Gunduz, M., Ouchida, M., Gunduz, E., Sakai, A., Fukushima, K., Nagatsuka, H., Ito, S., Honjo, N., Nishizaki, K., Shimizu, K. J. Cancer Res. Clin. Oncol. (2006) [Pubmed]
  2. DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways. Siripurapu, V., Meth, J., Kobayashi, N., Hamaguchi, M. J. Mol. Biol. (2005) [Pubmed]
  3. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Ramos, S., Khademi, F., Somesh, B.P., Rivero, F. Gene (2002) [Pubmed]
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