Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

strB - streptomycin resistance protein

Mannheimia varigena

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Disease relevance of strB

Temperature-sensitive (TS) plasmids were generated through chemical mutagenesis of a derivative of the streptomycin resistance parent plasmid pD70, isolated from Mannheimia hemolytica serotype 1 [1].

High impact information on strB

A temperature-sensitive (TS) plasmid was generated from the endogenous streptomycin resistance plasmid of Mannheimia hemolytica and used to engineer in-frame aroA deletion mutants of Mannheimia hemolytica, Pasteurella multocida, and Haemophilus somnus [2].
Loss of streptomycin resistance following treatment of the organism with acridine orange ablated the polymerizing activity [3].

Anatomical context of strB

After instillation into the tonsils of calves, an isolate that was efficient at colonizing was selected and transformed, using electroporation, with a 4.2-kilobase (kb) plasmid encoding for streptomycin resistance [4].

References

Generation and molecular characterization of new temperature-sensitive plasmids intended for genetic engineering of Pasteurellaceae. Briggs, R.E., Tatum, F.M. Appl. Environ. Microbiol. (2005) [Pubmed]
Construction of in-frame aroA deletion mutants of Mannheimia haemolytica, Pasteurella multocida, and Haemophilus somnus by using a new temperature-sensitive plasmid. Tatum, F.M., Briggs, R.E. Appl. Environ. Microbiol. (2005) [Pubmed]
Actin polymerization enhances Pasteurella haemolytica leukotoxicity. Basaraba, R.J., Byerly, A.N., Mosier, D.A., Butine, M.D., Stewart, G.C., Fenwick, B.W., Chengappa, M.M., Highlander, S.K. Vet. Microbiol. (1999) [Pubmed]
Development and testing of a unique strain of Pasteurella haemolytica for use in studies on colonization of the respiratory tract of cattle. Briggs, R.E., Frank, G.H., Zehr, E.S. Am. J. Vet. Res. (1998) [Pubmed]

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