Disease relevance of Laryngeal Edema

• Treatment of 193 episodes of laryngeal edema with C1 inhibitor concentrate in patients with hereditary angioedema [1].
• Despite treatment with epinephrine, antihistamines, and corticosteroids, the patient's condition progressed from that of severe laryngeal edema to total laryngospasm and complete airway obstruction [2].
• Minor reactions such as limited urticaria may be watched for progression or treatment with diphenhydramine, whereas more serious reactions such as angioedema or laryngeal edema require airway stability and ephinephrine administration [3].
• Eight other patients had complications like CSF leak, meningitis, pseudomeningocele, laryngeal edema, and transient worsening of neurological deficits [4].

High impact information on Laryngeal Edema

• We documented marked laryngeal edema and a sixfold increase in plasma histamine levels after challenge [5].
• A total of 342 laryngeal edemas cleared spontaneously without treatment, and 208 laryngeal edemas were successfully treated with C1 esterase inhibitor concentrate [6].
• The C1-INH concentrate was effective in all laryngeal edemas [1].
• When dosed appropriately, l-epinephrine is a less expensive and more widely available alternative to racemic epinephrine for the treatment of postextubation laryngeal edema [7].
• Postextubation laryngeal edema in adults. Risk factor evaluation and prevention by hydrocortisone [8].

Chemical compound and disease context of Laryngeal Edema

• OBJECTIVE: To determine whether any advantage exists using racemic epinephrine instead of the more potent and less expensive levo(1)-epinephrine in the treatment of postextubation laryngeal edema [7].
• Laryngeal edema related to ciprofloxacin therapy [9].
• HAE, caused by excess bradykinin formation as a result of C1 inhibitor deficiency, usually has its laryngeal edema effectively reversed by C1 inhibitor in less than 0.5 h [10].
• Effects of dexamethasone on laryngeal edema following short-term intubation [11].
• Acute laryngeal edema due to chloral hydrate [12].

Biological context of Laryngeal Edema

• CONCLUSIONS: Hydrocortisone did not significantly reduce the incidence of postextubation laryngeal edema or stridor [8].

Gene context of Laryngeal Edema

• The incidence of laryngeal edema was 13.1% for T1 disease, 23.8% for T2, and 21.4% for T3 and T4 disease [13].

References