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MeSH Review

Bacteriophage lambda

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Disease relevance of Bacteriophage lambda


High impact information on Bacteriophage lambda

  • We describe three different mutants (called pc) of the lambda phage repressor that are specifically deficient in the positive control function [6].
  • Using previously cloned P element sequences as a hybridization probe we have isolated a hybrid lambda phage clone carrying a 10 kb genomic DNA fragment containing a 1.3 kb P element insert and flanking sequences from the RpII locus [7].
  • Condensation and decondensation experiments with lambda-phage DNA show that toroid formation and stability are influenced by the number of arginine-rich anchoring domains in protamine [8].
  • A single DNA fragment containing both mu and delta immunoglobulin heavy chain genes has been cloned from normal BALB/c mouse liver DNA with a new lambda phage vector Charon 28 [9].
  • The chromosomal immune interferon gene of the rat (IFN-gamma) was identified by screening a recombinant rat lambda phage library with a human IFN-gamma cDNA probe [10].

Chemical compound and disease context of Bacteriophage lambda

  • The 6.5-kilobase DNA fragment was initially isolated from a lambda phage library made from a ouabain-resistant secondary transformant and subsequently was subcloned in the plasmid vector pAT153 [11].
  • CMA was 26- and 450-fold more active than ICMA and CHL, respectively, in producing DNA cross-links in isolated lambda-phage DNA [12].
  • In contrast to ADR, CMA, and 5-imino-3'-(3-cyano-4-morpholinyl)-3'-deaminoadriamycin (ICMA) have been shown to possess alkylating activity, as seen by their ability to produce DNA-DNA cross-links in human and murine tumor cells and in isolated lambda-phage DNA [12].
  • We have isolated the rat placental-type glutathione S-transferase (GST-P) gene from a lambda phage library using GST-P cDNA clone, pGP5 (Sugioka, Y., Kano, T., Okuda, A., Sakai, M., Kitagawa, T., and Muramatsu, M. (1985) Nucleic Acids Res. 13, 6049-6057), as a probe [13].
  • Oligo(A) not coded by DNA generating 3'-terminal heterogeneity in a lambda phage RNA [14].

Biological context of Bacteriophage lambda


Anatomical context of Bacteriophage lambda


Gene context of Bacteriophage lambda

  • Previous experiments have shown that this operator contains multiple sites recognized by the lambda phage repressor [25].
  • In addition, we have isolated a single lambda phage carrying both APOC1 and part of APOE [26].
  • The mutational lesions characteristic of a dnaJ null mutant--namely, temperature sensitivity for growth and defects in lambda phage and mini-F DNA replication--were all restored upon introduction of the cbpA gene on a multicopy plasmid [27].
  • In order to study this, we have perturbed the 3' UTR of Otx2 by inserting a small fragment of DNA from the lambda phage [28].
  • To elucidate the structure of the Cig30 gene, we have isolated a lambda phage genomic DNA clone containing the entire mouse gene and found that Cig30 consists of four exons that are spread over 4 kilobase pairs of genomic sequence [29].

Analytical, diagnostic and therapeutic context of Bacteriophage lambda


  1. Stabilization of proteins by a bacteriophage T4 gene cloned in Escherichia coli. Simon, L.D., Randolph, B., Irwin, N., Binkowski, G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  2. Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli. Shuman, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. De Groote, M.A., Ochsner, U.A., Shiloh, M.U., Nathan, C., McCord, J.M., Dinauer, M.C., Libby, S.J., Vazquez-Torres, A., Xu, Y., Fang, F.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis. Archelos, J.J., Trotter, J., Previtali, S., Weissbrich, B., Toyka, K.V., Hartung, H.P. Ann. Neurol. (1998) [Pubmed]
  5. Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin. Krieg, P., Feil, S., Fürstenberger, G., Bowden, G.T. J. Biol. Chem. (1993) [Pubmed]
  6. Repressor structure and the mechanism of positive control. Hochschild, A., Irwin, N., Ptashne, M. Cell (1983) [Pubmed]
  7. Molecular cloning of sequences from a Drosophila RNA polymerase II locus by P element transposon tagging. Searles, L.L., Jokerst, R.S., Bingham, P.M., Voelker, R.A., Greenleaf, A.L. Cell (1982) [Pubmed]
  8. Protamine-induced condensation and decondensation of the same DNA molecule. Brewer, L.R., Corzett, M., Balhorn, R. Science (1999) [Pubmed]
  9. Mapping of heavy chain genes for mouse immunoglobulins M and D. Liu, C.P., Tucker, P.W., Mushinski, J.F., Blattner, F.R. Science (1980) [Pubmed]
  10. Cloning and expression of the chromosomal immune interferon gene of the rat. Dijkema, R., van der Meide, P.H., Pouwels, P.H., Caspers, M., Dubbeld, M., Schellekens, H. EMBO J. (1985) [Pubmed]
  11. Molecular cloning of the mouse ouabain-resistance gene. Levenson, R., Racaniello, V., Albritton, L., Housman, D. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  12. Characterization of the DNA-DNA cross-linking activity of 3'-(3-cyano-4-morpholinyl)-3'-deaminoadriamycin. Jesson, M.I., Johnston, J.B., Robotham, E., Begleiter, A. Cancer Res. (1989) [Pubmed]
  13. The structure of the rat glutathione S-transferase P gene and related pseudogenes. Okuda, A., Sakai, M., Muramatsu, M. J. Biol. Chem. (1987) [Pubmed]
  14. Oligo(A) not coded by DNA generating 3'-terminal heterogeneity in a lambda phage RNA. Smith, G.R., Hedgpeth, J. J. Biol. Chem. (1975) [Pubmed]
  15. Isolation and characterization of the human prolactin gene. Truong, A.T., Duez, C., Belayew, A., Renard, A., Pictet, R., Bell, G.I., Martial, J.A. EMBO J. (1984) [Pubmed]
  16. Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor. Schmale, H., Heinsohn, S., Richter, D. EMBO J. (1983) [Pubmed]
  17. Detection and analysis of UV-induced mutations in mammalian cell DNA using a lambda phage shuttle vector. Glazer, P.M., Sarkar, S.N., Summers, W.C. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  18. Cell growth and lambda phage development controlled by the same essential Escherichia coli gene, ftsH/hflB. Herman, C., Ogura, T., Tomoyasu, T., Hiraga, S., Akiyama, Y., Ito, K., Thomas, R., D'Ari, R., Bouloc, P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Lee, I.Y., Westaway, D., Smit, A.F., Wang, K., Seto, J., Chen, L., Acharya, C., Ankener, M., Baskin, D., Cooper, C., Yao, H., Prusiner, S.B., Hood, L.E. Genome Res. (1998) [Pubmed]
  20. Molecular analysis of cloned human 18S ribosomal DNA segments. Wilson, G.N., Hollar, B.A., Waterson, J.R., Schmickel, R.D. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  21. Cloning and characterization of a human c-myc promoter-binding protein. Ray, R., Miller, D.M. Mol. Cell. Biol. (1991) [Pubmed]
  22. Complete nucleotide sequence of the gene for human heparin cofactor II and mapping to chromosomal band 22q11. Herzog, R., Lutz, S., Blin, N., Marasa, J.C., Blinder, M.A., Tollefsen, D.M. Biochemistry (1991) [Pubmed]
  23. Molecular characterization of mitomycin C-induced large deletions and tandem-base substitutions in the bone marrow of gpt delta transgenic mice. Takeiri, A., Mishima, M., Tanaka, K., Shioda, A., Ueda, O., Suzuki, H., Inoue, M., Masumura, K., Nohmi, T. Chem. Res. Toxicol. (2003) [Pubmed]
  24. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. Tanaka, M., Ozaki, S., Osakada, F., Mori, K., Okubo, M., Nakao, K. Int. Immunol. (1998) [Pubmed]
  25. Nucleotide sequence of the rightward operator of phage lambda. Maniatis, T., Jeffrey, A., Kleid, D.G. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  26. Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI. Lusis, A.J., Heinzmann, C., Sparkes, R.S., Scott, J., Knott, T.J., Geller, R., Sparkes, M.C., Mohandas, T. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  27. An analogue of the DnaJ molecular chaperone in Escherichia coli. Ueguchi, C., Kakeda, M., Yamada, H., Mizuno, T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  28. Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR. Boyl, P.P., Signore, M., Acampora, D., Martinez-Barbera, J.P., Ilengo, C., Annino, A., Corte, G., Simeone, A. Development (2001) [Pubmed]
  29. Cig30 and Pitx3 genes are arranged in a partially overlapping tail-to-tail array resulting in complementary transcripts. Tvrdik, P., Asadi, A., Kozak, L.P., Nuglozeh, E., Parente, F., Nedergaard, J., Jacobsson, A. J. Biol. Chem. (1999) [Pubmed]
  30. A family of genes coding for two serologically distinct chicken interferons. Sick, C., Schultz, U., Staeheli, P. J. Biol. Chem. (1996) [Pubmed]
  31. Rapid genetic engineering of human cytomegalovirus by using a lambda phage linear recombination system: demonstration that pp28 (UL99) is essential for production of infectious virus. Britt, W.J., Jarvis, M., Seo, J.Y., Drummond, D., Nelson, J. J. Virol. (2004) [Pubmed]
  32. Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region. Ponnazhagan, S., Hou, L., Kwon, B.S. J. Invest. Dermatol. (1994) [Pubmed]
  33. Cloning of the exonuclease III gene of Escherichia coli. Rogers, S.G., Weiss, B. Gene (1980) [Pubmed]
  34. Restriction patterns of model DNA treated with 5,6-dihydroxyindole, a potent cytotoxic intermediate of melanin synthesis: effect of u.v. irradiation. Miranda, M., Bonfigli, A., Zarivi, O., Manilla, A., Cimini, A.M., Arcadi, A. Mutagenesis (1987) [Pubmed]
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