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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Carlavirus

  • The 3'-terminal genes in genomic RNAs of four groups of plant positive strand RNA viruses (hordei-, furo-, tobra-, and carlaviruses) encode small proteins enriched in Cys residues [1].
  • Sequence comparisons revealed that the possible replicase proteins of tymoviruses are closely related to those of potexviruses and carlaviruses, suggesting a close evolutionary relationship among these viruses, despite differences in their genome organization and particle morphology [2].
  • We have studied the susceptibility or resistance of Solanum capsicastrum Link. et Schauer, S. comatum Sendt., S. dulcamara L., S. luteum Mill., S. malacoxylon Sendt. and S. nigrum L. to three aphid transmissible viruses [alfalfa mosaic alfamovirus (AMV), potato M. carlavirus (PVM) and potato S carlavirus (PVS)] [3].

High impact information on Carlavirus

  • ORF2 potentially encoded a small hydrophobic 6.4K protein, apparently homologous to small hydrophobic proteins of potex- and carlaviruses [4].
  • The 5'-proximal ORF1 encodes a product with substantial homology to the C-terminal portions of the putative RNA replicases of two other carlaviruses, potato viruses M and S [5].
  • It was found that the smooth membrane fraction was enriched in the carlavirus 7-kDa proteins [6].
  • The 227 kDa replicase of DVS shared 45.5-39.2% amino acid similarities to that of 8 other known carlaviruses [7].
  • The CP gene of DVS shares 25.2-55.2% and 42.9-56.1% similarities with that of 19 other carlaviruses at the amino acid and nucleotide levels, respectively [8].

Gene context of Carlavirus

  • The ORF1 replicase gene of LSV shares 40.9% to 56.8% and 48.9% and 58.6% identities with that of 5 other carlaviruses at the amino acid and nucleotide levels, respectively [9].
  • The 6K product had extensive homology with the comparable 6K protein of TNV-A and was also related to the 11K protein of shallot latent carlavirus, one of the "triple block" polypeptides involved in cell-to-cell virus movement [10].
  • ORF-1 motifs, characteristic for carlaviruses were found for methyltransferase (MTR), helicase (HEL) and RNA-dependent RNA polymerase (RdRp) [11].


  1. Small cysteine-rich proteins of different groups of plant RNA viruses are related to different families of nucleic acid-binding proteins. Koonin, E.V., Boyko, V.P., Dolja, V.V. Virology (1991) [Pubmed]
  2. The nucleotide sequence of the genomic RNA of kennedya yellow mosaic tymovirus-Jervis Bay isolate: relationships with potex- and carlaviruses. Ding, S., Keese, P., Gibbs, A. J. Gen. Virol. (1990) [Pubmed]
  3. New host-virus relations between different Solanum species and viruses. Takács, A.P., Kazinczi, G., Horváth, J., Pribék, D. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2001) [Pubmed]
  4. Nucleotide sequence of the 3'-terminal half of beet yellows closterovirus RNA genome: unique arrangement of eight virus genes. Agranovsky, A.A., Boyko, V.P., Karasev, A.V., Lunina, N.A., Koonin, E.V., Dolja, V.V. J. Gen. Virol. (1991) [Pubmed]
  5. Nucleotide sequence and gene organization of the 3'-terminal region of chrysanthemum virus B genomic RNA. Levay, K., Zavriev, S. J. Gen. Virol. (1991) [Pubmed]
  6. In vitro membrane binding of the translation products of the carlavirus 7-kDa protein genes. Morozov, S.Y., Miroshnichenko, N.A., Solovyev, A.G., Zelenina, D.A., Fedorkin, O.N., Lukasheva, L.I., Grachev, S.A., Chernov, B.K. Virology (1991) [Pubmed]
  7. Genome structure and complete sequence of genomic RNA of Daphne virus S. Lee, B.Y., Min, B.E., Ha, J.H., Lee, M.Y., Paek, K.H., Ryu, K.H. Arch. Virol. (2006) [Pubmed]
  8. Characterization of the 3'-terminal nucleotide sequence of two Korean isolates of Daphne virus S support its placement as a distinct species of the genus Carlavirus. Lee, B.Y., Choi, S.H., Ryu, K.H. Arch. Virol. (2003) [Pubmed]
  9. The complete nucleotide sequence of the genome RNA of Lily symptomless virus and its comparison with that of other carlaviruses. Choi, S.A., Ryu, K.H. Arch. Virol. (2003) [Pubmed]
  10. Nucleotide sequence of the genome of a citrus isolate of olive latent virus 1. Grieco, F., Savino, V., Martelli, G.P. Arch. Virol. (1996) [Pubmed]
  11. Complete nucleotide sequence and molecular probing of potato virus S genome. Matousek, J., Schubert, J., Ptácek, J., Kozlová, P., Dĕdic, P. Acta Virol. (2005) [Pubmed]
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