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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Pelvic Exenteration

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Disease relevance of Pelvic Exenteration

  • Consideration of the ability to deliver chemoradiation and the determinates of the tumor S-phase fraction in patients requiring pelvic exenteration for rectal cancer may be helpful in predicting outcome and planning therapy [1].

High impact information on Pelvic Exenteration

  • CONCLUSIONS: Routine use of prophylactic antibiotics, prophylactic subcutaneous heparin, and intensive postoperative monitoring appear to have reduced morbidity from pelvic exenteration [2].
  • METHODS: Between January 1988 and April 2001, 104 pelvic exenterations were performed by the division of gynecologic oncology at the University of Miami, School of Medicine. Twenty-five (24%) patients underwent vulvo-vaginal reconstruction at the time of the exenteration [3].
  • He received neoadjuvant chemoradiation consisting of 5-fluorouracil and mitomycin C with concurrent external beam radiation, followed by posterior pelvic exenteration [4].
  • Thirteen patients underwent reconstruction of the pelvic floor following pelvic exenteration using polyglactin 910 (Vicryl) mesh with omentum [5].
  • Despite progress in supportive peri-operative care, pelvic exenteration is a major undertaking that should be performed in centers with proven interest and expertise in the field [6].

Anatomical context of Pelvic Exenteration


Gene context of Pelvic Exenteration

  • Pelvic exenterations for gynecological malignancies: twenty-year experience at Roswell Park Cancer Institute [8].
  • From 1988 to 2003, 14 VRAM and 18 TRAM flap neovaginal reconstructions were performed on 32 women during the course of 22 (68%) total pelvic exenterations, 8 (25%) partial exenterations, and 2 (6%) radical vulvovaginectomies [9].


  1. Pelvic exenteration for locally advanced rectal carcinoma: factors predicting improved survival. Meterissian, S.H., Skibber, J.M., Giacco, G.G., el-Naggar, A.K., Hess, K.R., Rich, T.A. Surgery (1997) [Pubmed]
  2. Improvements in pelvic exenteration: factors responsible for reducing morbidity and mortality. Goldberg, J.M., Piver, M.S., Hempling, R.E., Aiduk, C., Blumenson, L., Recio, F.O. Ann. Surg. Oncol. (1998) [Pubmed]
  3. Vaginal reconstruction at the time of pelvic exenteration: a surgical and psychosexual analysis of techniques. Mirhashemi, R., Averette, H.E., Lambrou, N., Penalver, M.A., Mendez, L., Ghurani, G., Salom, E. Gynecol. Oncol. (2002) [Pubmed]
  4. Squamous-cell carcinoma of the pelvis in a giant condyloma acuminatum: use of neoadjuvant chemoradiation and surgical resection: report of a case. Hyacinthe, M., Karl, R., Coppola, D., Goodgame, T., Redwood, W., Goldenfarb, P., Ohori, N.P., Marcet, J. Dis. Colon Rectum (1998) [Pubmed]
  5. Use of Vicryl mesh in the reconstruction of the pelvic floor following exenteration. Hoffman, M.S., Roberts, W.S., LaPolla, J.P., Fiorica, J.V., Cavanagh, D. Gynecol. Oncol. (1989) [Pubmed]
  6. Development and evolution of pelvic exenteration: historical notes. Lopez, M.J., Petros, J.G., Augustinos, P. Seminars in surgical oncology. (1999) [Pubmed]
  7. The canine laboratory in the training of the oncology fellow. Christopherson, W.A., Buchsbaum, H.J., Voet, R., Lifshitz, S. Gynecol. Oncol. (1986) [Pubmed]
  8. Pelvic exenterations for gynecological malignancies: twenty-year experience at Roswell Park Cancer Institute. Sharma, S., Odunsi, K., Driscoll, D., Lele, S. Int. J. Gynecol. Cancer (2005) [Pubmed]
  9. Rectus abdominis myocutaneous flaps for neovaginal reconstruction after radical pelvic surgery. Soper, J.T., Havrilesky, L.J., Secord, A.A., Berchuck, A., Clarke-Pearson, D.L. Int. J. Gynecol. Cancer (2005) [Pubmed]
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