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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Omentum

  • CTIP and CT without IP had low sensitivity for detection of disease in the greater omentum (50% each) and small-bowel mesentery (38% and 59%, respectively), two areas that had the highest frequency of metastases [1].
  • Uptake of Tf-PEG liposomes in disseminated tumor cells of ascites and the greater omentum was significantly higher than that of PEG or bare liposomes and a significant increase in cisplatin levels was observed in these tumor cells [2].
  • CEA mRNA was found to be positive in both 10 peritoneal washes and 16 greater omenta of 30 gastric cancer patients, including all 6 patients who showed positive results for both cytology and RT-PCR of peritoneal wash and omentum [3].
  • Here, we show that embryonic day 29 porcine pancreas transplanted into the omentum of adult diabetic rats undergoes endocrine tissue differentiation over 20 wk and normalizes body weights and glucose tolerance [4].
  • Bloody pleural effusion secondary to infarction of omentum through a non-traumatic diaphragmatic hernia [5].

High impact information on Omentum


Chemical compound and disease context of Omentum


Biological context of Omentum


Anatomical context of Omentum


Associations of Omentum with chemical compounds

  • The addition of paclitaxel, by either schedule, to SU6668 treatment inhibited tumor spread in the peritoneal organs (omentum, pancreas, and diaphragm) even at low doses of paclitaxel [23].
  • Rates of penetration into the omentum remained at about 9% for ceftriaxone and between 50 and 70% for ornidazole [24].
  • It is concluded that gastroepiploic veins and arteries in the human omentum respond quite differently to dopamine; the alpha adrenoceptor-mediated contraction predominates over the relaxation mediated via dopamine D1 receptor subtype in the veins, and vice versa in the arteries [25].
  • To investigate the site-specific implantation of cancer cells in peritoneal dissemination, we inoculated CDF1 mice intraperitoneally with mouse P388 leukaemia cells labelled with bromodeoxyuridine (BrdU) and then observed immunohistochemically the distribution of the cells in the greater omentum taken from the mice using an anti-BrdU antibody [26].
  • 1. The effects of vasopressin and deamino-8-D-arginine vasopressin (DDAVP, desmopressin) were studied in artery rings (0.8-1 mm in external diameter) obtained from portions of human omentum during the course of abdominal operations (27 patients) [27].

Gene context of Omentum

  • Primary malignant ovarian tumors and metastases of the omentum and intestine contain TM antigen as determined by ELISA but in significantly lower concentrations than benign ovarian tumors (p=0.0056) [28].
  • Immunohistochemical analysis of CD31, CD36, and CD44 antigens in human omentum [29].
  • The regulation of tissue-plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) synthesis was studied in cultured human mesothelial cells derived from omentum (HOMC) [30].
  • Vimentin was present in both cell types, whereas cytokeratins 8 and 18 and desmin were only present in cells derived from omentum [31].
  • While normal omentum stroma produced LIF, its expression was substituted by SCF in inflamed tissues [32].

Analytical, diagnostic and therapeutic context of Omentum


  1. Peritoneal carcinomatosis: preoperative CT with intraperitoneal contrast material. Nelson, R.C., Chezmar, J.L., Hoel, M.J., Buck, D.R., Sugarbaker, P.H. Radiology. (1992) [Pubmed]
  2. Intracellular targeting therapy of cisplatin-encapsulated transferrin-polyethylene glycol liposome on peritoneal dissemination of gastric cancer. Iinuma, H., Maruyama, K., Okinaga, K., Sasaki, K., Sekine, T., Ishida, O., Ogiwara, N., Johkura, K., Yonemura, Y. Int. J. Cancer (2002) [Pubmed]
  3. Polymerase chain reaction for detection of carcinoembryonic antigen-expressing tumor cells on milky spots of the greater omentum in gastric cancer patients: a pilot study. Sakakura, C., Hagiwara, A., Shirasu, M., Yasuoka, R., Fujita, Y., Nakanishi, M., Aragane, H., Masuda, K., Shimomura, K., Abe, T., Yamagishi, H. Int. J. Cancer (2001) [Pubmed]
  4. Islet cell engraftment and control of diabetes in rats after transplantation of pig pancreatic anlagen. Rogers, S.A., Chen, F., Talcott, M., Hammerman, M.R. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  5. Bloody pleural effusion secondary to infarction of omentum through a non-traumatic diaphragmatic hernia. Schreier, L., Cutler, R.M., Saigal, V. Chest (1988) [Pubmed]
  6. CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Ansel, K.M., Harris, R.B., Cyster, J.G. Immunity (2002) [Pubmed]
  7. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. Hazan, R.B., Phillips, G.R., Qiao, R.F., Norton, L., Aaronson, S.A. J. Cell Biol. (2000) [Pubmed]
  8. Detection of pS2 messenger RNA in gynecological cancers. Wysocki, S.J., Hahnel, E., Masters, A., Smith, V., McCartney, A.J., Hahnel, R. Cancer Res. (1990) [Pubmed]
  9. Defective B1 cell homing to the peritoneal cavity and preferential recruitment of B1 cells in the target organs in a murine model for systemic lupus erythematosus. Ito, T., Ishikawa, S., Sato, T., Akadegawa, K., Yurino, H., Kitabatake, M., Hontsu, S., Ezaki, T., Kimura, H., Matsushima, K. J. Immunol. (2004) [Pubmed]
  10. Hepatic and splanchnic nitric oxide activity in patients with cirrhosis. Sarela, A.I., Mihaimeed, F.M., Batten, J.J., Davidson, B.R., Mathie, R.T. Gut (1999) [Pubmed]
  11. Effects of iso and xeno fetal liver fragments transplantation on acute and chronic liver failure in rats. Hagihara, M., Shimura, T., Takebe, K., Munkhbat, B., Tsuji, K. Cell transplantation. (1994) [Pubmed]
  12. Variations and topography of the arteries in the lesser omentum in humans. Weiglein, A.H. Clinical anatomy (New York, N.Y.) (1996) [Pubmed]
  13. Developing dendritic cells become 'lacy' cells packed with fat and glycogen. Maroof, A., English, N.R., Bedford, P.A., Gabrilovich, D.I., Knight, S.C. Immunology (2005) [Pubmed]
  14. Haemopoietic progenitors in the adult mouse omentum: permanent production of B lymphocytes and monocytes. Pinho, M.d.e. .F., Hurtado, S.P., El-Cheikh, M.C., Borojevic, R. Cell Tissue Res. (2005) [Pubmed]
  15. Hypofibrinolysis and increased PAI-1 are linked to atherothrombosis via insulin resistance and obesity. Juhan-Vague, I., Alessi, M.C., Morange, P.E. Ann. Med. (2000) [Pubmed]
  16. Expression of aquaporin-1 in the peritoneal tissues: localization and regulation by hyperosmolality. Ota, T., Kuwahara, M., Fan, S., Terada, Y., Akiba, T., Sasaki, S., Marumo, F. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2002) [Pubmed]
  17. Site-specific differences in the action of NRTI drugs on adipose tissue incubated in vitro with lymphoid cells, and their interaction with dietary lipids. Mattacks, C.A., Sadler, D., Pond, C.M. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2003) [Pubmed]
  18. Effects of radiopaque contrast media on the microcirculation of the rabbit omentum. Endrich, B., Ring, J., Intaglietta, M. Radiology. (1979) [Pubmed]
  19. Long-term follow-up after heterotopic splenic autotransplantation for traumatic splenic rupture. Budihna, N., Milcinski, M., Heberle, J. J. Nucl. Med. (1991) [Pubmed]
  20. Successful anastomosis between tissue-engineered intestine and native small bowel. Kaihara, S., Kim, S.S., Benvenuto, M., Choi, R., Kim, B.S., Mooney, D., Tanaka, K., Vacanti, J.P. Transplantation (1999) [Pubmed]
  21. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Medeiros, F., Corless, C.L., Duensing, A., Hornick, J.L., Oliveira, A.M., Heinrich, M.C., Fletcher, J.A., Fletcher, C.D. Am. J. Surg. Pathol. (2004) [Pubmed]
  22. Endometriosis with myxoid change simulating mucinous adenocarcinoma and pseudomyxoma peritonei. Hameed, A., Jafri, N., Copeland, L.J., O'Toole, R.V. Gynecol. Oncol. (1996) [Pubmed]
  23. The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically. Garofalo, A., Naumova, E., Manenti, L., Ghilardi, C., Ghisleni, G., Caniatti, M., Colombo, T., Cherrington, J.M., Scanziani, E., Nicoletti, M.I., Giavazzi, R. Clin. Cancer Res. (2003) [Pubmed]
  24. Concentrations in plasma and tissue penetration of ceftriaxone and ornidazole during liver transplantation. Steib, A., Jacoberger, B., Von Bandel, M., Beck, F., Beller, J.P., Boudjema, K., Koffel, J.C., Otteni, J.C. Antimicrob. Agents Chemother. (1993) [Pubmed]
  25. Responses to dopamine of isolated human and monkey veins compared with those of the arteries. Okamura, T., Yamazaki, M., Toda, N. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  26. Site-specific implantation in the milky spots of malignant cells in peritoneal dissemination: immunohistochemical observation in mice inoculated intraperitoneally with bromodeoxyuridine-labelled cells. Tsujimoto, H., Takhashi, T., Hagiwara, A., Shimotsuma, M., Sakakura, C., Osaki, K., Sasaki, S., Shirasu, M., Sakakibara, T., Ohyama, T. Br. J. Cancer (1995) [Pubmed]
  27. Relaxation of human isolated mesenteric arteries by vasopressin and desmopressin. Martínez, M.C., Vila, J.M., Aldasoro, M., Medina, P., Flor, B., Lluch, S. Br. J. Pharmacol. (1994) [Pubmed]
  28. Thrombomodulin, a receptor for the serine protease thrombin, is decreased in primary tumors and metastases but increased in ascitic fluids of patients with advanced ovarian cancer FIGO IIIc. Wilhelm, S., Schmitt, M., Parkinson, J., Kuhn, W., Graeff, H., Wilhelm, O.G. Int. J. Oncol. (1998) [Pubmed]
  29. Immunohistochemical analysis of CD31, CD36, and CD44 antigens in human omentum. Yildirim, A., Akkus, M., Nergiz, Y., Yuruker, S. Saudi medical journal. (2004) [Pubmed]
  30. Heparin stimulates fibrinolysis in mesothelial cells by selective induction of tissue-plasminogen activator but not plasminogen activator inhibitor-1 synthesis. Grulich-Henn, J., Preissner, K.T., Müller-Berghaus, G. Thromb. Haemost. (1990) [Pubmed]
  31. Cells derived from omental fat tissue and used for seeding vascular prostheses are not endothelial in origin. A study on the origin of epitheloid cells derived from omentum. Visser, M.J., van Bockel, J.H., van Muijen, G.N., van Hinsbergh, V.W. J. Vasc. Surg. (1991) [Pubmed]
  32. Myelopoiesis in the omentum of normal mice and during abdominal inflammatory processes. Pinho, M.d.e. .F., Hurtado, S.P., El-Cheikh, M.C., Rossi, M.I., Dutra, H.S., Borojevic, R. Cell Tissue Res. (2002) [Pubmed]
  33. Hyperthermic intraperitoneal doxorubicin: pharmacokinetics, metabolism, and tissue distribution in a rat model. Jacquet, P., Averbach, A., Stuart, O.A., Chang, D., Sugarbaker, P.H. Cancer Chemother. Pharmacol. (1998) [Pubmed]
  34. CD34 immunoexpression in stromal tumours of the gastrointestinal tract and in mesenteric fibromatoses. Monihan, J.M., Carr, N.J., Sobin, L.H. Histopathology (1994) [Pubmed]
  35. Preclinical development of the Islet Sheet. Storrs, R., Dorian, R., King, S.R., Lakey, J., Rilo, H. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
  36. Effects of bicarbonate/lactate solution on peritoneal advanced glycosylation end-product accumulation. Park, M.S., Kim, J.K., Holmes, C., Weiss, M.F. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2000) [Pubmed]
  37. Development of new tracheal prosthesis: autogenous mucosa-lined prosthesis made from polypropylene mesh. Suh, S.W., Kim, J., Baek, C.H., Kim, H. The International journal of artificial organs. (2000) [Pubmed]
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