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Chemical Compound Review

Vicryl     3,6-dimethyl-1,4-dioxane-2,5- dione; 1,4...

Synonyms: Atrigel, Polyglactin, Vicryl PM, Vicryl 910, Vicryl (TN), ...
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Disease relevance of Vicryl


Psychiatry related information on Vicryl


High impact information on Vicryl

  • We encapsulated bovine serum albumin (BSA) in injectable poly(DL-lactide- co-glycolide) (PLGA) 50/50 cylindrical implants and determined the mechanism of BSA instability [6].
  • Transgenic chondrocytes were assembled 3-dimensionally in alginate or in bioresorbable co-polymer fleeces of vicryl and polydioxanon embedded in low-melting-point agarose [7].
  • Such a pulmonary artery band was placed in seven 1 week old mongrel puppies by using a loop of an absorbable suture material (Vicryl) [8].
  • The differences in hydrolytic degradation of two size 2-0 synthetic absorbable sutures, Polyglycolic acid (Dexon) and Poly(glycolide-lactide) (Vicryl), in the buffer media of three different pH levels ranging from 5.25 to 10.09, were compared in terms of the percentage retention of tensile strength [9].
  • This pH dependent hydrolysis of Dexon and Vicryl sutures should command surgeons' attention in their selection of synthetic absorbable suture materials for particular needs [9].

Chemical compound and disease context of Vicryl


Biological context of Vicryl


Anatomical context of Vicryl


Associations of Vicryl with other chemical compounds


Gene context of Vicryl

  • To examine the role of BMP-2 in an extraskeletal site of rat using a controlled release system of peptides, we encapsulated the recombinant human BMP-2 (rhBMP-2) with poly(DL-lactide-co-glycolide) (PLGA) and implanted the rhBMP-2/PLGA capsules in the subcutaneous area of rats [30].
  • Nano size range (600 nm) pDNA-loaded in poly(DL-lactide-co-glycolide) polymer particles with high encapsulation efficiency (70%) were formulated, exhibiting sustained release of pDNA of over a month [15].
  • A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(DL-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine [31].
  • Among the five absorbable sutures and over the concentration range of this study, the monofilament Monocryl suture was the most sensitive toward superoxide ion-induced degradation, followed by Maxon, Vicryl, Dexon, and PDS II sutures [32].
  • To develop a controlled release system for bone morphogenetic protein (BMP), poly(DL-lactide-co-glycolide) (PLGA) capsules containing BMP were prepared by an interfacial precipitation method using a water-in-oil-in-water emulsion [33].

Analytical, diagnostic and therapeutic context of Vicryl

  • Plain catgut sutures lost relatively significant amounts of strength at both acidic and alkaline conditions when compared with Dexon and Vicryl sutures; hence, precaution should be taken when they are used in closing tissues in contact with acidic environment like the stomach [34].
  • A 90% splenectomy was performed, and the residual splenic fragment was wrapped in Vicryl mesh [35].
  • In order to simplify the vaccination schedule, we coencapsulated hsp65-DNA and trehalose dimicolate (TDM) into biodegradable poly(DL-lactide-co-glycolide) (PLGA) microspheres [36].
  • Using methods of radioimmunoassay (RIA), we measured levels of CGRP-ir and SP-ir in the dorsal quadrants of approximately the lumbar 4-5 (L4-L5) spinal segments of rats with a CCI induced using polyglactin (Vicryl), plain gut, or chromic gut suture [37].
  • PURPOSE: Preliminary assessment of feasibility, efficacy, acute and chronic side effects associated with permanent intraoperative placement of 125I vicryl mesh brachytherapy in a select group of high-risk Stage I NSCLC who have undergone video-assisted thoracoscopic resection (VATR) [38].


  1. Simplified interstitial therapy technique ("Vicryl" 125I) for unresectable lung cancer. Scott, W.P. Radiology. (1975) [Pubmed]
  2. Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres. Shahin, R., Leef, M., Eldridge, J., Hudson, M., Gilley, R. Infect. Immun. (1995) [Pubmed]
  3. Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-lactide-co-glycolide) microspheres. Allaoui-Attarki, K., Pecquet, S., Fattal, E., Trollé, S., Chachaty, E., Couvreur, P., Andremont, A. Infect. Immun. (1997) [Pubmed]
  4. Surgical repair of the kidney after blunt lesions of intermediate degree using a Vicryl mesh: an experimental study. Schoenenberger, A., Mettler, D., Roesler, H., Zimmermann, A., Bilweis, J., Schilt, W., Zingg, E.J. J. Urol. (1985) [Pubmed]
  5. Comparison of Maxon suture with Vicryl, chromic catgut, and PDS sutures in fascial closure in rats. Sanz, L.E., Patterson, J.A., Kamath, R., Willett, G., Ahmed, S.W., Butterfield, A.B. Obstetrics and gynecology. (1988) [Pubmed]
  6. Stabilization of proteins encapsulated in injectable poly (lactide- co-glycolide). Zhu, G., Mallery, S.R., Schwendeman, S.P. Nat. Biotechnol. (2000) [Pubmed]
  7. Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. Kaps, C., Bramlage, C., Smolian, H., Haisch, A., Ungethüm, U., Burmester, G.R., Sittinger, M., Gross, G., Häupl, T. Arthritis Rheum. (2002) [Pubmed]
  8. A reversible pulmonary artery band: preliminary experience. Rocchini, A.P., Gundry, S.R., Beekman, R.H., Gallagher, K.P., Heidelberger, K., Bove, E., Behrendt, D.M., Dysko, R.C., Rosen, K. J. Am. Coll. Cardiol. (1988) [Pubmed]
  9. A comparison of the effect of pH on the biodegradation of two synthetic absorbable sutures. Chu, C.C. Ann. Surg. (1982) [Pubmed]
  10. Comparison of polyglactic and polyglycolic acid sutures in reproductive tissue. Riddick, D.H., DeGrazia, C.T., Maenza, R.M. Fertil. Steril. (1977) [Pubmed]
  11. Complete small bowel obstruction in the early postoperative period complicating surgical sling procedure. Sloan, D.A. The American surgeon. (1994) [Pubmed]
  12. The risk of infection of three synthetic materials used in rectopexy with or without colonic resection for rectal prolapse. Athanasiadis, S., Weyand, G., Heiligers, J., Heumuller, L., Barthelmes, L. International journal of colorectal disease. (1996) [Pubmed]
  13. Remodelling the filtration bleb. Morgan, J.E., Diamond, J.P., Cook, S.D. The British journal of ophthalmology. (2002) [Pubmed]
  14. Biodegradable PLGA microspheres as a sustained release system for a new luteinizing hormone-releasing hormone (LHRH) antagonist. Du, L., Cheng, J., Chi, Q., Qie, J., Liu, Y., Mei, X. Chem. Pharm. Bull. (2006) [Pubmed]
  15. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Cohen, H., Levy, R.J., Gao, J., Fishbein, I., Kousaev, V., Sosnowski, S., Slomkowski, S., Golomb, G. Gene Ther. (2000) [Pubmed]
  16. Serum dependent variability in the adherence of tumour cells to surgical sutures. O'Dwyer, P., Ravikumar, T.S., Steele, G. The British journal of surgery. (1985) [Pubmed]
  17. Injection of perfluoropropane gas to prevent hypotony in eyes undergoing tube implant surgery. Franks, W.A., Hitchings, R.A. Ophthalmology (1990) [Pubmed]
  18. Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein. Kaneko, H., Bednarek, I., Wierzbicki, A., Kiszka, I., Dmochowski, M., Wasik, T.J., Kaneko, Y., Kozbor, D. Virology (2000) [Pubmed]
  19. Poly(DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Jones, D.H., Corris, S., McDonald, S., Clegg, J.C., Farrar, G.H. Vaccine (1997) [Pubmed]
  20. Amniotic membrane transplantation in entropion surgery. Ti, S.E., Tow, S.L., Chee, S.P. Ophthalmology (2001) [Pubmed]
  21. Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses. Vajdy, M., Selby, M., Medina-Selby, A., Coit, D., Hall, J., Tandeske, L., Chien, D., Hu, C., Rosa, D., Singh, M., Kazzaz, J., Nguyen, S., Coates, S., Ng, P., Abrignani, S., Lin, Y.L., Houghton, M., O'Hagan, D.T. J. Gen. Virol. (2006) [Pubmed]
  22. Effects of a hyaluronan-based membrane (Seprafilm) on intraperitoneally disseminated human colon cancer cell growth in a nude mouse model. Hubbard, S.C., Burns, J.W. Dis. Colon Rectum (2002) [Pubmed]
  23. Fabrication and characterization of permeable degradable poly(dl-lactide-co-glycolide) (PLGA) hollow fiber phase inversion membranes for use as nerve tract guidance channels. Wen, X., Tresco, P.A. Biomaterials (2006) [Pubmed]
  24. Fibroblast growth factor-2 alters the effect of eroding polylactide-polyglycolide on osteogenesis in the bone chamber. Winet, H., Bao, J.Y. J. Biomed. Mater. Res. (1998) [Pubmed]
  25. Combined continuous ultra low dose rate irradiation and radiofrequency hyperthermia in the C3H mouse. Sapozink, M.D., Palos, B., Goffinet, D.R., Hahn, G.M. Int. J. Radiat. Oncol. Biol. Phys. (1983) [Pubmed]
  26. Thrombogenicity of different suture materials as revealed by scanning electron microscopy. Dahlke, H., Dociu, N., Thurau, K. J. Biomed. Mater. Res. (1980) [Pubmed]
  27. Material properties of ophthalmic sutures after sterilization and disinfection. Shuttleworth, G.N., Vaughn, L.F., Hoh, H.B. Journal of cataract and refractive surgery. (1999) [Pubmed]
  28. Sustained bronchodilation with isoproterenol poly(glycolide-co-lactide) microspheres. Lai, Y.L., Mehta, R.C., Thacker, A.A., Yoo, S.D., McNamara, P.J., DeLuca, P.P. Pharm. Res. (1993) [Pubmed]
  29. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. Jepson, M.A., Simmons, N.L., O'Hagan, D.T., Hirst, B.H. Journal of drug targeting. (1993) [Pubmed]
  30. The role of recombinant human bone morphogenetic protein-2 in PLGA capsules at an extraskeletal site of the rat. Isobe, M., Yamazaki, Y., Mori, M., Ishihara, K., Nakabayashi, N., Amagasa, T. J. Biomed. Mater. Res. (1999) [Pubmed]
  31. Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice. Luo, Y., O'Hagan, D., Zhou, H., Singh, M., Ulmer, J., Reisfeld, R.A., James Primus, F., Xiang, R. Vaccine (2003) [Pubmed]
  32. The role of superoxide ions in the degradation of synthetic absorbable sutures. Lee, K.H., Chu, C.C. J. Biomed. Mater. Res. (2000) [Pubmed]
  33. Bone morphogenetic protein encapsulated with a biodegradable and biocompatible polymer. Isobe, M., Yamazaki, Y., Oida, S., Ishihara, K., Nakabayashi, N., Amagasa, T. J. Biomed. Mater. Res. (1996) [Pubmed]
  34. An in vitro evaluation of the stability of mechanical properties of surgical suture materials in various pH conditions. Chu, C.C., Moncrief, G. Ann. Surg. (1983) [Pubmed]
  35. Partial splenectomy for Gaucher's disease. Rodgers, B.M., Tribble, C., Joob, A. Ann. Surg. (1987) [Pubmed]
  36. Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protects mice against a virulent strain of Mycobacterium tuberculosis. Lima, K.M., Santos, S.A., Lima, V.M., Coelho-Castelo, A.A., Rodrigues, J.M., Silva, C.L. Gene Ther. (2003) [Pubmed]
  37. Chromic gut suture reduces calcitonin-gene-related peptide and substance P levels in the spinal cord following chronic constriction injury in the rat. Xu, J., Pollock, C.H., Kajander, K.C. Pain (1996) [Pubmed]
  38. Intraoperative 125I brachytherapy for high-risk stage I non-small cell lung carcinoma. Chen, A., Galloway, M., Landreneau, R., d'Amato, T., Colonias, A., Karlovits, S., Quinn, A., Santucci, T., Kalnicki, S., Brown, D. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
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