Disease relevance of Aphasia, Broca

• The neurological sequelae included memory deficit (46%), mental retardation (42%), hemiplegia (34%), emotional and behavioral disturbance (24%), epilepsy (20%), motor aphasia (16%), cranial nerve palsies (16%), involuntary limb movement (8%) and blindness (2%) [1].

Psychiatry related information on Aphasia, Broca

• Monosomy for 13q21 leads to 13q22 was associated with mental retardation, expressive aphasia, microcephaly, hand abnormalities, and short stature [2].
• Isolated, progressive language disturbance, especially nonfluent aphasia, is the hallmark of the syndrome called ¿Primary Progressive Aphasia¿ or PPA [3].

High impact information on Aphasia, Broca

• Bromocriptine, a dopamine agonist, was tested on four patients, two men and two women, with nonfluent aphasia [4].
• The Trace-Deletion Hypothesis (henceforth TDH; Grodzinsky 1986, 1995) states that syntactic traces are deleted in agrammatism and that whenever a trace is deleted, a default strategy is activated [5].
• The hypothesis that closed-class items which participate in theta-role assignment are less problematic in agrammatism than items which do not (Rizzi, 1985) is put to an empirical test [6].
• His neurological condition was lethargic (Glasgow Coma Scale of 13) with nonfluent aphasia [7].

Gene context of Aphasia, Broca

• An isolated neurological deficit, motor aphasia, persisted after recovery from the coma [8].

References