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Gene Review

TDH  -  L-threonine dehydrogenase (pseudogene)

Homo sapiens

Synonyms: FLJ25033, Inactive L-threonine 3-dehydrogenase, mitochondrial, SDR14E1P, Short chain dehydrogenase/reductase family 14E member 1 pseudogene
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Disease relevance of TDH

  • The TDH result was 41.6 +/- 31.7% (SD) in a group of chronic pancreatitis patients (n = 22) and 91.5 +/- 4.8% in the control group (n = 47) [1].
  • The results indicate that in normal subjects, but not in prolactinomas, NOM induces a moderate but significant reduction in TDH secretion [2].
  • Characterisation of a haemolysin related to Vp-TDH produced by a Kanagawa phenomenon-negative clinical isolate of Vibrio parahaemolyticus [3].
  • The Trace-Deletion Hypothesis (henceforth TDH; Grodzinsky 1986, 1995) states that syntactic traces are deleted in agrammatism and that whenever a trace is deleted, a default strategy is activated [4].
  • In this study, NoSo and NoS tau thresholds were measured in normal-hearing subjects and in subjects having hearing loss due to otosclerosis, using both standard TDH earphones encased in NAF-48490-1 circumaural cushions and deeply seated Etymotic 3A insert earphones [5].

High impact information on TDH


Biological context of TDH

  • RESULTS: The human TDH gene is located at 8p23-22 and has 8 exons spanning 10 kb that would have been expected to encode a 369 residue ORF [8].
  • The production level is optimal when the recombinant plasmid carries the TDH promoter, the complete 2mu and the leu2D selection marker [9].
  • Two ORFs were identified in the 5'-region of the TDH gene, a third one, coding for 176 amino acids overlaps the ACT gene in antisense direction completely [7].
  • 4-Dihydromethyltrisporate dehydrogenase (TDH) converts the (+) mating type sex pheromone 4-dihydromethyltrisporate into methyltrisporate [10].
  • In contrast to gene expression, TDH enzyme activity depends on the sexual status of the mycelium [10].

Anatomical context of TDH

  • The action of HlyA has been analyzed using protocols previously applied to TDH: lysis and flux experiments on human erythrocytes showed that HlyA similarly causes lysis after cell swelling (by colloid osmosis) due to an elevation of cation permeability [11].
  • Major difficulties in defining completely the exact effector mechanisms involved in the pathogenesis of HP include the absence of a reliable in vitro correlate of antigen-specific effector T cells (the so called TDH cell) and the overwhelming versatility of the macrophage [12].

Associations of TDH with chemical compounds


Other interactions of TDH

  • Immunological similarities of Vp-TRH not only to Vp-TDH but also to hemolytic toxins produced by Vibrio hollisae and Vibrio cholerae non-O1, both of which are also enteropathogens closely related to V. parahaemolyticus, were demonstrated [15].

Analytical, diagnostic and therapeutic context of TDH

  • Expression of the TDH encoding TSP1 gene was analyzed qualitatively using reverse-transcribed PCR [10].
  • The attenuation provided by TDH earphones in MX-41/AR and P/N 51 cushions, Audiocup earphone enclosures and ER-3A insert earphones with ER3-14 foam earplugs was determined for 30 normally hearing subjects using a real-ear attenuation at threshold paradigm [16].
  • Vp-TDH/II was purified by ammonium sulphate precipitation and successive filtrations on DEAE-cellulose, hydroxyapatite, Sepharose 4B and Mono Q columns [3].


  1. In-vitro test of haptocorrin degradation for biological diagnosis of exocrine pancreatic dysfunction using duodenal juice collected during endoscopy. Guéant, J.L., Champigneulle, B., Djalali, M., Bigard, M.A., Gaucher, P., Hassouni, A., Nicolas, J.P. Lancet (1986) [Pubmed]
  2. The effect of nomifensine on thyroid-stimulating hormone (TSH) in normal and hyperprolactinemic subjects. Giusti, M., Mazzocchi, G., Mignone, D., Tarditi, W., Contessini, M., Bessarione, D., Giordano, G. Neuroendocrinology (1983) [Pubmed]
  3. Characterisation of a haemolysin related to Vp-TDH produced by a Kanagawa phenomenon-negative clinical isolate of Vibrio parahaemolyticus. Nagayama, K., Yamamoto, K., Mitawani, T., Honda, T. J. Med. Microbiol. (1995) [Pubmed]
  4. Double-agents and trace-deletion in agrammatism. Beretta, A., Munn, A. Brain and language. (1998) [Pubmed]
  5. The effect of conductive hearing loss on the masking-level difference: insert versus standard earphones. Hall, J.W., Grose, J.H. The Journal of the Acoustical Society of America. (1994) [Pubmed]
  6. The First Crystal Structure of l-Threonine Dehydrogenase. Ishikawa, K., Higashi, N., Nakamura, T., Matsuura, T., Nakagawa, A. J. Mol. Biol. (2007) [Pubmed]
  7. Sexuality and parasitism share common regulatory pathways in the fungus Parasitella parasitica. Schultze, K., Schimek, C., Wöstemeyer, J., Burmester, A. Gene (2005) [Pubmed]
  8. The human L-threonine 3-dehydrogenase gene is an expressed pseudogene. Edgar, A.J. BMC Genet. (2002) [Pubmed]
  9. High-level production and isolation of human recombinant alpha 1-proteinase inhibitor in yeast. Hoylaerts, M., Weyens, A., Bollen, A., Harford, N., Cabezón, T. FEBS Lett. (1986) [Pubmed]
  10. 4-Dihydromethyltrisporate dehydrogenase, an enzyme of the sex hormone pathway in Mucor mucedo, is constitutively transcribed but its activity is differently regulated in (+) and (-) mating types. Schimek, C., Petzold, A., Schultze, K., Wetzel, J., Wolschendorf, F., Burmester, A., Wöstemeyer, J. Fungal Genet. Biol. (2005) [Pubmed]
  11. Membrane attack induced by HlyA, a pore-forming toxin of Vibrio cholerae. Huntley, J.S., Sathyamoorthy, V., Hall, R.H., Hall, A.C. Human & experimental toxicology. (1997) [Pubmed]
  12. Hypersensitivity pneumonitis--pathology and pathogenesis. Richerson, H.B. Clinical reviews in allergy. (1983) [Pubmed]
  13. In vivo threonine oxidation rate is dependent on threonine dietary supply in growing pigs fed low to adequate levels. Le Floc'h, N., Obled, C., Sève, B. J. Nutr. (1995) [Pubmed]
  14. Measuring performance during the menstrual cycle: a model using oral contraceptives. Redman, L.M., Weatherby, R.P. Medicine and science in sports and exercise. (2004) [Pubmed]
  15. Properties of a hemolysin related to the thermostable direct hemolysin produced by a Kanagawa phenomenon negative, clinical isolate of Vibrio parahaemolyticus. Honda, T., Ni, Y.X., Hata, A., Yoh, M., Miwatani, T., Okamoto, T., Goshima, K., Takakura, H., Tsunasawa, S., Sakiyama, F. Can. J. Microbiol. (1990) [Pubmed]
  16. Attenuation provided by four different audiometric earphone systems. Frank, T., Wright, D.C. Ear and hearing. (1990) [Pubmed]
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