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Gene Review

DFN8  -  deafness, X-linked 8

Homo sapiens

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Disease relevance of DFN8


Psychiatry related information on DFN8


High impact information on DFN8


Chemical compound and disease context of DFN8


Biological context of DFN8


Anatomical context of DFN8


Associations of DFN8 with chemical compounds

  • Advantages of donepezil over placebo were also observed in cognition and activities of daily living (ADL) assessed by the Mini-Mental State Examination at weeks 24, 36, and 52, and the end point (p < 0.02) and by the Progressive Deterioration Scale at week 52 and the end point (p < 0.05) [30].
  • Intelligence quotient (IQ) was assessed using the nonverbal Raven Standard Progressive Matrix test [31].
  • 2. Progressive lowering of ionic strength by sucrose or NaCl replacement gave a similar activation profile for taurine influx as found earlier for residual K+(86Rb+) flux [32].
  • Creatine supplementation had a significant positive effect (p < 0.0001) on both working memory (backward digit span) and intelligence (Raven's Advanced Progressive Matrices), both tasks that require speed of processing [33].
  • Samples were fixed in 4% paraformaldehyde plus 0.5% glutaraldehyde and processed into Lowicryl K4M resin by the 'Progressive Lowering of Temperature' technique [34].

Other interactions of DFN8


Analytical, diagnostic and therapeutic context of DFN8


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  23. Progressive gaa expansions in dorsal root ganglia of Friedreich's ataxia patients. De Biase, I., Rasmussen, A., Endres, D., Al-Mahdawi, S., Monticelli, A., Cocozza, S., Pook, M., Bidichandani, S.I. Ann. Neurol. (2007) [Pubmed]
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  30. A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD. Winblad, B., Engedal, K., Soininen, H., Verhey, F., Waldemar, G., Wimo, A., Wetterholm, A.L., Zhang, R., Haglund, A., Subbiah, P. Neurology (2001) [Pubmed]
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  34. Localization of interleukin (IL) -4 but not IL-5 to human mast cell secretory granules by immunoelectron microscopy. Wilson, S.J., Shute, J.K., Holgate, S.T., Howarth, P.H., Bradding, P. Clin. Exp. Allergy (2000) [Pubmed]
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