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MeSH Review:

Ectromelia, Infectious

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Disease relevance of Ectromelia, Infectious

Here, we report the expression of a functional soluble CD30 homologue, viral CD30 (vCD30), encoded by ectromelia (mousepox) virus, a poxvirus that causes a severe disease related to human smallpox [1].
Variola virus, the causative agent of smallpox in humans, and ECTV, which causes mousepox in mice, both encode receptor homologs that are thought to interfere with host IFN function [2].

High impact information on Ectromelia, Infectious

Genetically resistant mice infected with the IL-4-expressing virus developed symptoms of acute mousepox accompanied by high mortality, similar to the disease seen when genetically sensitive mice are infected with the virulent Moscow strain [3].
Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox [4].
Serial backcross analysis of genetic resistance to mousepox, using marker loci for Rmp-2 and Rmp-3 [5].
Biosynthesis of the IFN-gamma binding protein of ectromelia virus, the causative agent of mousepox [6].
Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model [7].

Gene context of Ectromelia, Infectious

Mousepox was identified in a single mouse-holding room in early 1999 after a group of 20 CAF1/Hsd mice were inoculated SC with a killed murine spindle cell tumor line, S1509A [8].

References

Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus. Saraiva, M., Smith, P., Fallon, P.G., Alcami, A. J. Exp. Med. (2002) [Pubmed]
Interferon function is not required for recovery from a secondary poxvirus infection. Panchanathan, V., Chaudhri, G., Karupiah, G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. Jackson, R.J., Ramsay, A.J., Christensen, C.D., Beaton, S., Hall, D.F., Ramshaw, I.A. J. Virol. (2001) [Pubmed]
Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox. Brownstein, D.G., Gras, L. J. Virol. (1995) [Pubmed]
Serial backcross analysis of genetic resistance to mousepox, using marker loci for Rmp-2 and Rmp-3. Brownstein, D.G., Bhatt, P.N., Gras, L., Budris, T. J. Virol. (1992) [Pubmed]
Biosynthesis of the IFN-gamma binding protein of ectromelia virus, the causative agent of mousepox. Bai, H., Buller, R.M., Chen, N., Green, M., Nuara, A.A. Virology (2005) [Pubmed]
Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model. Buller, R.M., Owens, G., Schriewer, J., Melman, L., Beadle, J.R., Hostetler, K.Y. Virology (2004) [Pubmed]
Mousepox resulting from use of ectromelia virus-contaminated, imported mouse serum. Lipman, N.S., Perkins, S., Nguyen, H., Pfeffer, M., Meyer, H. Comp. Med. (2000) [Pubmed]

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