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MeSH Review:

Arcus Senilis

Haines, A. et al., Menotti, A. et al., Gibson, J.M. et al., Segal, P. et al., Battisti, C. et al., et al.

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Disease relevance of Arcus Senilis

Schnyder corneal crystalline dystrophy (SCCD) comprises corneal opacities often associated with precocious arcus senilis and genua valga [1].
Indications for measuring blood cholesterol are: a family history of premature coronary heart disease or hyperlipidaemia, personal history of coronary heart disease, clinical evidence of raised lipids (xanthelasma, corneal arcus under 50, xanthomas at any age), a high risk of coronary heart disease according to a risk score [2].
Significant associations with senile cataract were age, female sex, myopia, social class and antihypertensive treatment, whilst for senile macular degeneration age and the absence of arcus senilis were significant [3].

High impact information on Arcus Senilis

Both xanthelasma and corneal arcus were associated with increased levels of plasma cholesterol and low-density lipoprotein cholesterol (LDL-C), especially in young males [4].
Total serum cholesterol and triglyceride levels were not associated with corneal arcus [5].
No association between corneal arcus and fasting plasma glucose was found in all ages and both sexes [6].

Biological context of Arcus Senilis

These were mean blood pressure, age, arm circumference (protective), early death of parents, cigarette smoking, forced expiratory volume (protective), CHD, arcus senilis, vital capacity (protective), xanthelasma, and serum cholesterol [7].

References

Schnyder corneal crystalline dystrophy: description of a new family with evidence of abnormal lipid storage in skin fibroblasts. Battisti, C., Dotti, M.T., Malandrini, A., Pezzella, F., Bardelli, A.M., Federico, A. Am. J. Med. Genet. (1998) [Pubmed]
Prevention of cardiovascular disease. Haines, A., Patterson, D., Rayner, M., Hyland, K. Occasional paper (Royal College of General Practitioners) (1992) [Pubmed]
Senile cataract and senile macular degeneration: an investigation into possible risk factors. Gibson, J.M., Shaw, D.E., Rosenthal, A.R. Transactions of the ophthalmological societies of the United Kingdom. (1986) [Pubmed]
The association of dyslipoproteinemia with corneal arcus and xanthelasma. The Lipid Research Clinics Program Prevalence Study. Segal, P., Insull, W., Chambless, L.E., Stinnett, S., LaRosa, J.C., Weissfeld, L., Halfon, S., Kwiterovitch, P.O., Little, J.A. Circulation (1986) [Pubmed]
Serum lipid parameters and the prevalence of corneal arcus in a dyslipidaemic patient population. Meyer, D., Liebenberg, P.H., Maritz, F.J. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners. (2004) [Pubmed]
Corneal arcus associated with dyslipidemia. Lertchavanakul, A., Laksanaphuk, P., Tomtitchong, T. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (2002) [Pubmed]
Prediction of all causes of death as a function of some factors commonly measured in cardiovascular population surveys. Menotti, A., Conti, S., Dima, F., Giampaoli, S., Giuli, B., Rumi, A., Seccareccia, F., Signoretti, P. Preventive medicine. (1983) [Pubmed]

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