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MeSH Review

Corneal Opacity

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Disease relevance of Corneal Opacity


Psychiatry related information on Corneal Opacity


High impact information on Corneal Opacity


Chemical compound and disease context of Corneal Opacity


Biological context of Corneal Opacity


Anatomical context of Corneal Opacity


Gene context of Corneal Opacity

  • Familial lecithin:cholesterol acyltransferase (LCAT) deficiency is a hereditary disorder with clinical manifestations including corneal opacity, premature atherosclerosis and renal failure [26].
  • Macular corneal dystrophy (MCD) is an autosomal recessive disease characterized by corneal opacities and caused by mutations in a carbohydrate sulfotransferase gene, known as CHST6 [27].
  • Cat4 is the second largest allelism group in the collection of mouse dominant eye mutations recovered in Neuherberg and carriers express anterior polar cataract, central corneal opacity, and lens-corneal adhesions [28].
  • Accumulating evidence suggests the involvement of TGF-beta in the process of corneal opacity, which is one of the serious causes of visual loss [29].
  • RESULTS: Corneal opacity in IL-6(-/-) mice was substantially diminished in comparison with IL-6(+/+) hosts 24 to 48 hours after intracorneal viral infection, and corneal levels of (MIP)-2 and MIP-1alpha were significantly reduced [30].

Analytical, diagnostic and therapeutic context of Corneal Opacity


  1. Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV. Bassi, M.T., Manzoni, M., Monti, E., Pizzo, M.T., Ballabio, A., Borsani, G. Am. J. Hum. Genet. (2000) [Pubmed]
  2. Mouse models for the Wolf-Hirschhorn deletion syndrome. Näf, D., Wilson, L.A., Bergstrom, R.A., Smith, R.S., Goodwin, N.C., Verkerk, A., van Ommen , G.J., Ackerman, S.L., Frankel, W.N., Schimenti, J.C. Hum. Mol. Genet. (2001) [Pubmed]
  3. Two different allelic mutations in a Finnish family with lecithin:cholesterol acyltransferase deficiency. Miettinen, H., Gylling, H., Ulmanen, I., Miettinen, T.A., Kontula, K. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  4. Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis. Tumpey, T.M., Cheng, H., Cook, D.N., Smithies, O., Oakes, J.E., Lausch, R.N. J. Virol. (1998) [Pubmed]
  5. Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress. Dieter, M.Z., Freshwater, S.L., Miller, M.L., Shertzer, H.G., Dalton, T.P., Nebert, D.W. Free Radic. Biol. Med. (2003) [Pubmed]
  6. A new case of Balci's syndrome (corneal opacity, microphthalmia, microcephaly, mental retardation, and generalized muscular spasticity associated with congenital heart disease). Balci, S., Demirçeken, F.G., Ocal, B., Zorlu, P., Teziç, T. Turk. J. Pediatr. (2001) [Pubmed]
  7. Fish eye syndrome: a molecular defect in the lecithin-cholesterol acyltransferase (LCAT) gene associated with normal alpha-LCAT-specific activity. Implications for classification and prognosis. Klein, H.G., Santamarina-Fojo, S., Duverger, N., Clerc, M., Dumon, M.F., Albers, J.J., Marcovina, S., Brewer, H.B. J. Clin. Invest. (1993) [Pubmed]
  8. Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. Chakravarti, S., Magnuson, T., Lass, J.H., Jepsen, K.J., LaMantia, C., Carroll, H. J. Cell Biol. (1998) [Pubmed]
  9. Macular corneal dystrophy: failure to synthesize a mature keratan sulfate proteoglycan. Hassell, J.R., Newsome, D.A., Krachmer, J.H., Rodrigues, M.M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  10. Defective processing of keratan sulfate in macular corneal dystrophy. Nakazawa, K., Hassell, J.R., Hascall, V.C., Lohmander, L.S., Newsome, D.A., Krachmer, J. J. Biol. Chem. (1984) [Pubmed]
  11. Phase I/II evaluation of safety and efficacy of a matrix-targeted retroviral vector bearing a dominant negative cyclin G1 construct (Md-dnG1) as adjunctive intervention for superficial corneal opacity/corneal scarring. Song, J.C., McDonnell, P.J., Gordon, E.M., Hall, F.L., Anderson, W.F. Hum. Gene Ther. (2003) [Pubmed]
  12. Increase in axial length of the macaque monkey eye after corneal opacification. Wiesel, T.N., Raviola, E. Invest. Ophthalmol. Vis. Sci. (1979) [Pubmed]
  13. Carcinogenicity of DDT (dichlorodiphenyl trichloroethane) in pure inbred Swiss mice. Kashyap, S.K., Nigam, S.K., Karnik, A.B., Gupta, R.C., Chatterjee, S.K. Int. J. Cancer (1977) [Pubmed]
  14. The effects of cidofovir 1% with and without cyclosporin a 1% as a topical treatment of acute adenoviral keratoconjunctivitis: a controlled clinical pilot study. Hillenkamp, J., Reinhard, T., Ross, R.S., Böhringer, D., Cartsburg, O., Roggendorf, M., De Clercq, E., Godehardt, E., Sundmacher, R. Ophthalmology (2002) [Pubmed]
  15. Effect of diclofenac on corneal haze after photorefractive keratectomy in rabbits. Nassaralla, B.A., Szerenyi, K., Wang, X.W., al Reaves, T., McDonnell, P.J. Ophthalmology (1995) [Pubmed]
  16. Bilateral corneal opacities. Occurrence in a patient treated with oral isotretinoin. Weiss, J., Degnan, M., Leupold, R., Lumpkin, L.R. Archives of dermatology. (1981) [Pubmed]
  17. Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice. Drew, A.F., Schiman, H.L., Kombrinck, K.W., Bugge, T.H., Degen, J.L., Kaufman, A.H. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  18. An experimental animal model of adenovirus-induced ocular disease. The cotton rat. Tsai, J.C., Garlinghouse, G., McDonnell, P.J., Trousdale, M.D. Arch. Ophthalmol. (1992) [Pubmed]
  19. Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop). Lyon, M.F., Bogani, D., Boyd, Y., Guillot, P., Favor, J. Mol. Vis. (2000) [Pubmed]
  20. Automated superficial lamellar keratectomy augmented by excimer laser masked PTK in the management of severe superficial corneal opacities. Alio, J.L., Javaloy, J., Merayo, J., Galal, A. The British journal of ophthalmology. (2004) [Pubmed]
  21. Macular corneal dystrophy: immunochemical characterization using monoclonal antibodies. SundarRaj, N., Barbacci-Tobin, E., Howe, W.E., Robertson, S.M., Limetti, G. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  22. Silencing Toll-like receptor-9 in Pseudomonas aeruginosa keratitis. Huang, X., Barrett, R.P., McClellan, S.A., Hazlett, L.D. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  23. Oval lipid corneal opacities in beagles: VI. Quantitation of excess stromal cholesterol and phospholipid. Ekins, M.B., Sgoutas, D.S., Waring, G.O., Kanes, G.J. Exp. Eye Res. (1983) [Pubmed]
  24. New phenotype of adult alpha-L-iduronidase deficiency (mucopolysaccharidosis I) masquerading as Friedreich's ataxia with cardiopathy. Jellinger, K., Paulus, W., Grisold, W., Paschke, E. Clin. Neuropathol. (1990) [Pubmed]
  25. Three cases of oblique facial cleft. Mishima, K., Sugahara, T., Mori, Y., Sakuda, M. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (1996) [Pubmed]
  26. Molecular defect in familial lecithin:cholesterol acyltransferase (LCAT) deficiency: a single nucleotide insertion in LCAT gene causes a complete deficient type of the disease. Bujo, H., Kusunoki, J., Ogasawara, M., Yamamoto, T., Ohta, Y., Shimada, T., Saito, Y., Yoshida, S. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  27. Novel mutations in the CHST6 gene causing macular corneal dystrophy. Abbruzzese, C., Kuhn, U., Molina, F., Rama, P., De Luca, M. Clin. Genet. (2004) [Pubmed]
  28. The mouse Cat4 locus maps to chromosome 8 and mutants express lens-corneal adhesion. Favor, J., Grimes, P., Neuhäuser-Klaus, A., Pretsch, W., Stambolian, D. Mamm. Genome (1997) [Pubmed]
  29. Blockade of TGF-beta by in vivo gene transfer of a soluble TGF-beta type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis. Sakamoto, T., Ueno, H., Sonoda, K., Hisatomi, T., Shimizu, K., Ohashi, H., Inomata, H. Gene Ther. (2000) [Pubmed]
  30. Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation. Fenton, R.R., Molesworth-Kenyon, S., Oakes, J.E., Lausch, R.N. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  31. Bilateral corneal neovascularization and opacification associated with unmonitored contact lens wear. Wong, A.L., Weissman, B.A., Mondino, B.J. Am. J. Ophthalmol. (2003) [Pubmed]
  32. Effect of ketorolac on Pseudomonas aeruginosa ocular infection in rabbits. Fraser-Smith, E.B., Matthews, T.R. Journal of ocular pharmacology. (1988) [Pubmed]
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