The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, T-Cell Receptor alpha

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Genes, T-Cell Receptor alpha

  • Taken together these results demonstrate that hGATA-3 is a novel lineage-specific hematopoietic transcription factor that appears to play an important role in regulating the T cell-specific expression of the TCR alpha gene [1].
  • The calcium ionophore A23187 induces the accumulation of TCR-alpha but not -beta transcripts; and in contrast to CHX, it increases the rate of TCR-alpha gene transcription and the expression of large nuclear TCR-alpha precursor transcripts [2].
  • The protein synthesis inhibitor cycloheximide (CHX) induces a 20-fold increase in mature TCR-alpha transcript accumulation without a concomitant increase in TCR-alpha gene transcription suggesting that CHX reverses the nuclear post-transcriptional events which prevent mature TCR-alpha mRNA accumulation [2].
  • PFGE analysis of the T cell line Molt 4 suggests a greater than 600-kb deletion involving the TCR-alpha gene [3].
  • The C delta 1 gene consists of two exons, one that encodes an extracellular Ig-like domain (exon 1) and the other that encodes either a very short or possibly a lacking CP region, a transmembrane region, and a cytoplasmic tail (exon 2); these are located within TCR alpha gene locus [4].

Anatomical context of Genes, T-Cell Receptor alpha

  • To investigate this question, mixed radiation bone marrow chimeras were established in which wild-type T cell precursors capable of full maturation were diluted with precursors deficient in maturation potential because of targeted mutations of the RAG1 or TCR-alpha genes [5].

Gene context of Genes, T-Cell Receptor alpha

  • These experiments suggest that cross-linking of the CD3 modules on pro-T cells mimics the signaling function expected of the pre-TcR complex, which is found at the surface of pre-T cells prior to functional TcR alpha gene rearrangement [6].
  • There was a 10-fold increase in the 1.3-kb TcR beta transcript and a twofold increase in TcR alpha gene expression, even though Thy-1 expression was in general similar to controls [7].
  • The functional rearranged TCR alpha gene is composed of a member of the V alpha 1 family, the junctional gene J alpha TT11 and C alpha [8].
  • To further study this question, we have utilized a polymerase chain reaction-based strategy to isolate and sequence excision products of secondary TCR alpha gene rearrangement events [9].
  • We conclude that there is a marked non random TCR alpha gene distribution in atopy using both V alpha family and anchored PCR [10].


  1. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. Ho, I.C., Vorhees, P., Marin, N., Oakley, B.K., Tsai, S.F., Orkin, S.H., Leiden, J.M. EMBO J. (1991) [Pubmed]
  2. Induction of T-cell receptor-alpha and -beta mRNA in SL12 cells can occur by transcriptional and post-transcriptional mechanisms. Wilkinson, M.F., MacLeod, C.L. EMBO J. (1988) [Pubmed]
  3. Sizing of the human T cell receptor alpha locus and detection of a large deletion in the Molt-4 cell line. Roth, M.S., Collins, F.S., Ginsburg, D. Blood (1988) [Pubmed]
  4. The four TCR genes of teleost fish: the cDNA and genomic DNA analysis of Japanese flounder (Paralichthys olivaceus) TCR alpha-, beta-, gamma-, and delta-chains. Nam, B.H., Hirono, I., Aoki, T. J. Immunol. (2003) [Pubmed]
  5. Homeostasis limits the development of mature CD8+ but not CD4+ thymocytes. van Meerwijk, J.P., Marguerat, S., MacDonald, H.R. J. Immunol. (1998) [Pubmed]
  6. CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Jacobs, H., Vandeputte, D., Tolkamp, L., de Vries, E., Borst, J., Berns, A. Eur. J. Immunol. (1994) [Pubmed]
  7. T cell receptor gene expression in autoimmune mice. Mountz, J.D., Huppi, K.E., Seldin, M.F., Mushinski, J.F., Steinberg, A.D. J. Immunol. (1986) [Pubmed]
  8. T cell receptor alpha and beta gene expression in a murine antigen-specific T suppressor lymphocyte clone with cytolytic potential. Heuer, J., Degwert, J., Pauels, H.G., Kölsch, E. J. Immunol. (1991) [Pubmed]
  9. Excision products of TCR V alpha recombination contain in-frame rearrangements: evidence for continued V(D)J recombination in TCR+ thymocytes. McCormack, W.T., Liu, M., Postema, C., Thompson, C.B., Turka, L.A. Int. Immunol. (1993) [Pubmed]
  10. Non random usage of T cell receptor alpha gene expression in atopy using anchored PCR. Mansur, A.H., Gelder, C.M., Holland, D., Campell, D.A., Griffin, A., Cunliffe, W., Markham, A.F., Morrison, J.F. Adv. Exp. Med. Biol. (1996) [Pubmed]
WikiGenes - Universities