Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

MeSH Review:

Alcohol-Related Disorders

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Alcohol-Related Disorders

The current results emphasize the proposed pathogenetic role of increased plasma homocysteine levels in alcohol-related disorders (i.e., brain atrophy, alcohol withdrawal seizures) [1].
As a result, alcoholics frequently experience deficiencies in proteins and vitamins, particularly vitamin A, which may contribute to liver disease and other serious alcohol-related disorders [2].

High impact information on Alcohol-Related Disorders

Developmental delay in P300 production in children at high risk for developing alcohol-related disorders [3].
Carbohydrate-deficient transferrin may thus offer a new possibility of diagnosing alcohol-related disorders [4].
Classical benzodiazepines such as diazepam are widely used tranquillisers and hypnotics in various neuropsychiatric diseases including alcohol-related disorders [5].
A persistent increase in cortisol concentration as a result of chronic intoxication could therefore result in alcohol-related disorders such as sleep disruption, cognitive deficits, diabetes, and mood disturbances [6].
CONCLUSIONS: Our data suggest that CYP2E1 repeat polymorphism does not seem to constitute a major factor for interindividual differences in CYP2E1 expression and susceptibility to alcohol-related disorders in whites [7].

Chemical compound and disease context of Alcohol-Related Disorders

Alcohol use, abuse, and alcohol-related disorders among ethnic groups in Hungary. Part I: Csángós from Egyházaskozár Region [8].

Gene context of Alcohol-Related Disorders

Alcohol use, abuse, and alcohol-related disorders among ethnic groups in Hungary. Part II: Palócs from Mátraderecske [9].
The recent developments elucidating the role of NPY in emotion and alcohol dependence are reviewed and the potential of the NPY system as a novel therapeutic strategy in the treatment of anxiety, depression and alcohol-related disorders is examined [10].

References

Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS). Bleich, S., Carl, M., Bayerlein, K., Reulbach, U., Biermann, T., Hillemacher, T., Bönsch, D., Kornhuber, J. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
Relationships between nutrition, alcohol use, and liver disease. Lieber, C.S. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism. (2003) [Pubmed]
Developmental delay in P300 production in children at high risk for developing alcohol-related disorders. Hill, S.Y., Shen, S., Locke, J., Steinhauer, S.R., Konicky, C., Lowers, L., Connolly, J. Biol. Psychiatry (1999) [Pubmed]
Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Stibler, H. Clin. Chem. (1991) [Pubmed]
alpha2-gamma-Aminobutyric acid (GABA)A receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo. Täuber, M., Calame-Droz, E., Prut, L., Rudolph, U., Crestani, F. Eur. J. Neurosci. (2003) [Pubmed]
Increased salivary cortisol concentrations during chronic alcohol intoxication in a naturalistic clinical sample of men. Adinoff, B., Ruether, K., Krebaum, S., Iranmanesh, A., Williams, M.J. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics. Plee-Gautier, E., Foresto, F., Ferrara, R., Bodénez, P., Simon, B., Manno, M., Berthou, F., Lucas, D. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
Alcohol use, abuse, and alcohol-related disorders among ethnic groups in Hungary. Part I: Csángós from Egyházaskozár Region. Béres, J., Czeizel, A.E., Métneki, J., Nagy, I., Agarwal, D.P., Benkmann, H.G., Goedde, H.W., Schmutte, P. Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur. (1995) [Pubmed]
Alcohol use, abuse, and alcohol-related disorders among ethnic groups in Hungary. Part II: Palócs from Mátraderecske. Agarwal, D.P., Benkmann, H.G., Goedde, H.W., Püschel, K., Béres, J., Czeizel, A.E., Dobos, I., Métneki, J., Szekér, E., Sahegyi, J. Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur. (1995) [Pubmed]
Neuropeptide y: role in emotion and alcohol dependence. Carvajal, C., Dumont, Y., Quirion, R. CNS & neurological disorders drug targets. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.