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High impact information on Comfrey


Biological context of Comfrey


Anatomical context of Comfrey

  • The pyrrolizidine alkaloids of comfrey may serve as an experimental tool to study the process of bleb formation and the intimate relationship between hepatocyte and sinusoidal injury in the liver [7].

Associations of Comfrey with chemical compounds


Gene context of Comfrey

  • The main objective of this trial (CODEC_2004) was to compare the efficacy and tolerability of an ointment of Comfrey extract (Extr. Rad. Symphyti) with that of a Diclofenac gel in the treatment of acute unilateral ankle sprain (distortion) [6].

Analytical, diagnostic and therapeutic context of Comfrey


  1. Atropine as possible contaminant of comfrey tea. Awang, D.V., Kindack, D.G. Lancet (1989) [Pubmed]
  2. Toxic pyrrolizidine alkaloids in comfrey. Mattocks, A.R. Lancet (1980) [Pubmed]
  3. Screening botanical extracts for quinoid metabolites. Johnson, B.M., Bolton, J.L., van Breemen, R.B. Chem. Res. Toxicol. (2001) [Pubmed]
  4. Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography. Kim, N.C., Oberlies, N.H., Brine, D.R., Handy, R.W., Wani, M.C., Wall, M.E. J. Nat. Prod. (2001) [Pubmed]
  5. A bidesmosidic hederagenin hexasaccharide from the roots of Symphytum officinale. Mohammad, F.V., Noorwala, M., Ahmad, V.U., Sener, B. Phytochemistry (1995) [Pubmed]
  6. Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study. Predel, H.G., Giannetti, B., Koll, R., Bulitta, M., Staiger, C. Phytomedicine (2005) [Pubmed]
  7. Hepatocyte membrane injury and bleb formation following low dose comfrey toxicity in rats. Yeong, M.L., Wakefield, S.J., Ford, H.C. International journal of experimental pathology. (1993) [Pubmed]
  8. The effect of an aqueous extract of comfrey on prostaglandin synthesis by rat isolated stomach. Stamford, I.F., Tavares, I.A. J. Pharm. Pharmacol. (1983) [Pubmed]
  9. Symphytoxide A, a triterpenoid saponin from the roots of Symphytum officinale. Ahmad, V.U., Noorwala, M., Mohammad, F.V., Sener, B., Gilani, A.H., Aftab, K. Phytochemistry (1993) [Pubmed]
  10. Consumption of poisonous plants (Senecio jacobaea, Symphytum officinale, Pteridium aquilinum, Hypericum perforatum) by rats: chronic toxicity, mineral metabolism, and hepatic drug-metabolizing enzymes. Garrett, B.J., Cheeke, P.R., Miranda, C.L., Goeger, D.E., Buhler, D.R. Toxicol. Lett. (1982) [Pubmed]
  11. A new triterpene glycoside from the roots of Symphytum officinale. Ahmad, V.U., Noorwala, M., Mohammad, F.V., Sener, B. J. Nat. Prod. (1993) [Pubmed]
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