High impact information on Comfrey

• Atropine as possible contaminant of comfrey tea [1].
• Toxic pyrrolizidine alkaloids in comfrey [2].
• However, extracts of Sassafras albidum (Nutt.) Nees (sassafras), Symphytum officinale L [3].
• Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography [4].
• A bidesmosidic hederagenin hexasaccharide from the roots of Symphytum officinale [5].

Biological context of Comfrey

• The 95% confidence interval for the AUC (Comfrey extract minus Diclofenac gel) was 19.01-103.09h*N/cm2 and was completely above the margin of non-inferiority [6].

Anatomical context of Comfrey

• The pyrrolizidine alkaloids of comfrey may serve as an experimental tool to study the process of bleb formation and the intimate relationship between hepatocyte and sinusoidal injury in the liver [7].

Associations of Comfrey with chemical compounds

• The effect of an aqueous extract of comfrey on prostaglandin synthesis by rat isolated stomach [8].
• Symphytoxide A, a triterpenoid saponin from the roots of Symphytum officinale [9].
• Comfrey and alfalfa increased (P less than 0.05) the activity of aminopyrine N-demethylase [10].
• Chemical investigation of the EtOH-soluble portion of Symphytum officinale roots has resulted in the isolation of a new pentacyclic triterpene glycoside of oleanolic acid [11].
• It was confirmatorily shown that Comfrey extract is non-inferior to diclofenac [6].

Gene context of Comfrey

• The main objective of this trial (CODEC_2004) was to compare the efficacy and tolerability of an ointment of Comfrey extract (Extr. Rad. Symphyti) with that of a Diclofenac gel in the treatment of acute unilateral ankle sprain (distortion) [6].

Analytical, diagnostic and therapeutic context of Comfrey

• Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study [6].

References