Disease relevance of Wasting Disease, Chronic

• Three White-tailed Deer shot within 5 km during the 2001 hunting season in Wisconsin tested positive for chronic wasting disease, a prion disease of cervids [1].
• Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins [2].
• Among the most notable prion disorders in ungulates are scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer [3].

High impact information on Wasting Disease, Chronic

• Transmission of prions from mule deer and elk with chronic wasting disease to transgenic mice expressing cervid PrP [4].
• Chronic wasting disease in free-ranging Wisconsin White-tailed Deer [1].
• Low frequency of PrP genotype 225SF among free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease [5].
• Comparison of histological lesions and immunohistochemical staining of proteinase-resistant prion protein in a naturally occurring spongiform encephalopathy of free-ranging mule deer (Odocoileus hemionus) with those of chronic wasting disease of captive mule deer [6].
• Amyloid plaques were demonstrable in central nervous system tissues of adult captive mule deer affected with chronic wasting disease, a transmissible primary spongiform encephalopathy [7].

Gene context of Wasting Disease, Chronic

• We generated mice expressing cervid prion protein to produce a transgenic system simulating chronic wasting disease (CWD) in deer and elk [4].
• Chronic wasting disease in Canada: Part 1 [8].

References