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High impact information on Clematis


Associations of Clematis with chemical compounds

  • An oleanolic acid based bisglycoside from Clematis montana roots [4].
  • Clemontanoside-C, a new hederagenin-based saponin isolated from the stems of Clematis montana, was identified by chemical and spectroscopic methods as hederagenin-3-O-alpha-L-arabinopyranosyl (1-3)-alpha-L-rhamnopyranosyl (1-2)-alpha-L-arabinopyranoside [5].
  • Clematoside-S, a triterpenoid saponin from the roots of Clematis grata [6].
  • Sterol and lipid composition of Phymactis clematis (Drayton) [7].
  • Anemonin, the dilactone of cyclobutane-1,2-diol-1,2-diacrylic acid derived from the cyclodimerization of protoanemonin, a known blistering agent, was isolated from Clematis hirsutissima, a plant used by the Nez Perce and Teton Sioux nations as a horse stimulant [8].

Gene context of Clematis

  • The ethanol extracts of three Clematis species inhibited the activities of COX-1, COX-2 and 5-LOX in the different extents [9].
  • We have previously reported that the ethanol extract of Clematis pickeringii inhibited COX-1 [9].
  • The stem extract of Clematis pickeringii showed the highest inhibitory activities among the three species on COX-1, COX-2 and 5-LOX with the IC(50) values of 73.5, 101.2 and 29.3 microg/mL [9].
  • Whereas staurosporin induced the degradation of 32 kDa caspase-3 precursor and the production of 85-kDa cleavage products of PARP in a time-dependent fashion, Clematis mandshurica treatment prevented those manifestations [10].
  • Although the level of Bcl-2 expression was decreased after staurosporin treatment, it was sustained after the combination treatment with Clematis mandshurica [10].


  1. Isolation and structures of two divinyl ether fatty acids from Clematis vitalba. Hamberg, M. Lipids (2004) [Pubmed]
  2. Two new antifungal saponins from the Tibetan herbal medicine Clematis tangutica. Du, Z., Zhu, N., Ze-Ren-Wang-Mu, N., Shen, Y. Planta Med. (2003) [Pubmed]
  3. Triterpenoid saponins from Clematis tangutica. Zhong, H.M., Chen, C.X., Tian, X., Chui, Y.X., Chen, Y.Z. Planta Med. (2001) [Pubmed]
  4. An oleanolic acid based bisglycoside from Clematis montana roots. Thapliyal, R.P., Bahuguna, R.P. Phytochemistry (1993) [Pubmed]
  5. Clemontanoside-C, a saponin from Clematis montana. Thapliyal, R.P., Bahuguna, R.P. Phytochemistry (1993) [Pubmed]
  6. Clematoside-S, a triterpenoid saponin from the roots of Clematis grata. Sati, O.P., Uniyal, S.K., Bahuguna, S., Kikuchi, T. Phytochemistry (1990) [Pubmed]
  7. Sterol and lipid composition of Phymactis clematis (Drayton). Munoz, M.O., Atkinson, B., Idler, D.R. Comp. Biochem. Physiol., B (1976) [Pubmed]
  8. Native American medicinal plants. Anemonin from the horse stimulant Clematis hirsutissima. Kern, J.R., Cardellina, J.H. Journal of ethnopharmacology. (1983) [Pubmed]
  9. Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae). Li, R.W., Lin, G.D., Leach, D.N., Waterman, P.G., Myers, S.P. Journal of ethnopharmacology. (2006) [Pubmed]
  10. Clematis mandshurica protected to apoptosis of rat chondrocytes. Lee, S.W., Chung, W.T., Choi, S.M., Kim, K.T., Yoo, K.S., Yoo, Y.H. Journal of ethnopharmacology. (2005) [Pubmed]
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