Gene Review:
Casp3 - caspase 3
Rattus norvegicus
Synonyms:
Apopain, CASP-3, CPP-32, Caspase-3, Cpp32, ...
- Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. Yakovlev, A.G., Knoblach, S.M., Fan, L., Fox, G.B., Goodnight, R., Faden, A.I. J. Neurosci. (1997)
- Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity. Buchmann, A., Willy, C., Buenemann, C.L., Stroh, C., Schmiechen, A., Schwarz, M. Cell Death Differ. (1999)
- CPP32/CASPASE-3-like proteases in hypoxia-induced apoptosis in developing brain neurons. Bossenmeyer-Pourié, C., Koziel, V., Daval, J.L. Brain Res. Mol. Brain Res. (1999)
- Caspase inhibitors block the retinal ganglion cell death following optic nerve transection. Chaudhary, P., Ahmed, F., Quebada, P., Sharma, S.C. Brain Res. Mol. Brain Res. (1999)
- Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. Chen, J., Nagayama, T., Jin, K., Stetler, R.A., Zhu, R.L., Graham, S.H., Simon, R.P. J. Neurosci. (1998)
- Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. Aikawa, R., Komuro, I., Yamazaki, T., Zou, Y., Kudoh, S., Tanaka, M., Shiojima, I., Hiroi, Y., Yazaki, Y. J. Clin. Invest. (1997)
- A role for caspases in lens fiber differentiation. Ishizaki, Y., Jacobson, M.D., Raff, M.C. J. Cell Biol. (1998)
- Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. Deshmukh, M., Vasilakos, J., Deckwerth, T.L., Lampe, P.A., Shivers, B.D., Johnson, E.M. J. Cell Biol. (1996)
- Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Hara, H., Friedlander, R.M., Gagliardini, V., Ayata, C., Fink, K., Huang, Z., Shimizu-Sasamata, M., Yuan, J., Moskowitz, M.A. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. Thomson, A.M., Rogers, J.T., Leedman, P.J. J. Biol. Chem. (2000)
- Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat. Black, S.C., Huang, J.Q., Rezaiefar, P., Radinovic, S., Eberhart, A., Nicholson, D.W., Rodger, I.W. J. Mol. Cell. Cardiol. (1998)
- Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy. Gillardon, F., Böttiger, B., Schmitz, B., Zimmermann, M., Hossmann, K.A. Brain Res. Mol. Brain Res. (1997)
- Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats. Iwasaki, K., Mishima, K., Egashira, N., Al-Khatib, I.H., Ishibashi, D., Irie, K., Kobayashi, H., Egawa, T., Fujiwara, M. J. Pharmacol. Sci. (2003)
- Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein. Bonfoco, E., Li, E., Kolbinger, F., Cooper, N.R. J. Biol. Chem. (2001)
- Involvement of CPP32/Caspase-3 in c-Myc-induced apoptosis. Kangas, A., Nicholson, D.W., Hölttä, E. Oncogene (1998)
- Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons. Ni, B., Wu, X., Du, Y., Su, Y., Hamilton-Byrd, E., Rockey, P.K., Rosteck, P., Poirier, G.G., Paul, S.M. J. Neurosci. (1997)
- Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: role of ceramide in apoptosis. Scurlock, B., Dawson, G. J. Neurosci. Res. (1999)
- Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death. Citron, B.A., Arnold, P.M., Sebastian, C., Qin, F., Malladi, S., Ameenuddin, S., Landis, M.E., Festoff, B.W. Exp. Neurol. (2000)
- Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Flaws, J.A., Kugu, K., Trbovich, A.M., DeSanti, A., Tilly, K.I., Hirshfield, A.N., Tilly, J.L. Endocrinology (1995)
- Impaired apoptotic death signaling in inflammatory lung neutrophils is associated with decreased expression of interleukin-1 beta converting enzyme family proteases (caspases). Watson, R.W., Rotstein, O.D., Parodo, J., Jimenez, M., Soric, I., Bitar, R., Marshall, J.C. Surgery (1997)
- Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. Kermer, P., Klöcker, N., Labes, M., Bähr, M. J. Neurosci. (1998)
- Differential c-Fos and caspase expression following kainic acid excitotoxicity. Ferrer, I., López, E., Blanco, R., Rivera, R., Krupinski, J., Martí, E. Acta Neuropathol. (2000)
- Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support. Stefanis, L., Troy, C.M., Qi, H., Greene, L.A. J. Neurochem. (1997)
- A DEVD-inhibited caspase other than CPP32 is involved in the commitment of cerebellar granule neurons to apoptosis induced by K+ deprivation. D'Mello, S.R., Aglieco, F., Roberts, M.R., Borodezt, K., Haycock, J.W. J. Neurochem. (1998)
- Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells. Okado, T., Terada, Y., Tanaka, H., Inoshita, S., Nakao, A., Sasaki, S. Kidney Int. (2002)
- Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes. Inayat-Hussain, S.H., Couet, C., Cohen, G.M., Cain, K. Hepatology (1997)
- Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. Asahi, M., Hoshimaru, M., Uemura, Y., Tokime, T., Kojima, M., Ohtsuka, T., Matsuura, N., Aoki, T., Shibahara, K., Kikuchi, H. J. Cereb. Blood Flow Metab. (1997)
- Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration. Akbar, M.T., Wells, D.J., Latchman, D.S., de Belleroche, J. Brain Res. Mol. Brain Res. (2001)
- Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury. Kaushal, G.P., Singh, A.B., Shah, S.V. Am. J. Physiol. (1998)
- Apoptotic protein expression and activation of caspases is changed following cholinergic denervation and hippocampal sympathetic ingrowth in rat hippocampus. Kolasa, K., Harrell, L.E. Neuroscience (2000)
- Biochemical and immunological characterization of the variant surface coat glycoprotein shed by African trypanosomes. Diffley, P., Straus, D.C. Infect. Immun. (1986)