Disease relevance of Pygeum

• BACKGROUND: Tadenan (a Pygeum africanum extract) is a drug used in the treatment of benign prostatic hyperplasia [1].

High impact information on Pygeum

• Tadenan, an extract of Pygeum africanum, is a therapeutic prescribed in Europe to relieve symptoms of obstructive bladder dysfunction secondary to benign prostatic hyperplasia [2].
• Effect of Pygeum africanum tadenan on micturition and prostate growth of the rat secondary to coadministered treatment and post-treatment with dihydrotestosterone [3].
• Pygeum africanum and beta-sitosterol are also used by many patients with BPH, either alone or in combination with saw palmetto [4].
• Several phytotherapies, including saw palmetto, Pygeum africanum, curbicin, and isoflavone-containing supplements (red clover [Trifoleum pratense] and soy), are widely used in patients with BPH [5].
• CONCLUSION: The combination of 25mg Pygeum africanum and 300mg stinging nettle extracts produced clinical and urodynamic effects similar to placebo in a group of HBP patients [6].

Anatomical context of Pygeum

• The effect of a Pygeum africanum extract (Tadenan) (Pa), used in the treatment of micturition disorders associated with BPH, has been examined on the proliferation of rat prostatic stromal cells stimulated by different growth factors [7].

Associations of Pygeum with chemical compounds

• Effects of Pygeum africanum extract (Tadenan) on vasoactive intestinal peptide receptors, G proteins, and adenylyl cyclase in rat ventral prostate [1].
• Effect of Pygeum africanum extract on A23187-stimulated production of lipoxygenase metabolites from human polymorphonuclear cells [8].

References