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Chemical Compound Review

Erazaban     docosan-1-ol

Synonyms: Herepair, Docosanol, Lidakol, Lidavol, Tadenan, ...
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Disease relevance of Abreva


High impact information on Abreva

  • Tadenan, an extract of Pygeum africanum, is a therapeutic prescribed in Europe to relieve symptoms of obstructive bladder dysfunction secondary to benign prostatic hyperplasia [4].
  • Tadenan daily resulted in reduced bladder hypertrophy, improved compliance, improved contractile responses to nearly normal levels of isolated bladder strips to all stimuli tested and reversal of obstruction induced structural damage to cellular and subcellular organelle membranes [4].
  • RESULTS: Tadenan treatment of castrated/testosterone-replaced rats was performed in order to interfere with prostatic cell proliferation [5].
  • CONCLUSIONS: The observed regulatory role of Tadenan on various prostatic components of the adenylyl cyclase system, together with previous findings on protein kinase C-mediated signal transduction, open a complex array of possibilities of direct actions of this phytotherapeutic agent in the prostate [5].
  • The effect of a Pygeum africanum extract (Tadenan) (Pa), used in the treatment of micturition disorders associated with BPH, has been examined on the proliferation of rat prostatic stromal cells stimulated by different growth factors [6].

Chemical compound and disease context of Abreva


Biological context of Abreva


Anatomical context of Abreva


Associations of Abreva with other chemical compounds


Analytical, diagnostic and therapeutic context of Abreva


  1. Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Katz, D.H., Marcelletti, J.F., Khalil, M.H., Pope, L.E., Katz, L.R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Protective effect of Tadenan on bladder function secondary to partial outlet obstruction. Levin, R.M., Riffaud, J.P., Bellamy, F., Rohrmann, D., Habib, M., Krasnopolsky, L., Zhao, Y., Wein, A.J. J. Urol. (1996) [Pubmed]
  3. Improved contractility of obstructed bladders after Tadenan treatment is associated with reversal of altered myosin isoform expression. Gomes, C.M., Disanto, M.E., Horan, P., Levin, R.M., Wein, A.J., Chacko, S. J. Urol. (2000) [Pubmed]
  4. Effect of oral Tadenan treatment on rabbit bladder structure and function after partial outlet obstruction. Levin, R.M., Hass, M.A., Bellamy, F., Horan, P., Whitbeck, K., Chow, P.H., Kung, L.S., Gosling, J. J. Urol. (2002) [Pubmed]
  5. Effects of Pygeum africanum extract (Tadenan) on vasoactive intestinal peptide receptors, G proteins, and adenylyl cyclase in rat ventral prostate. Solano, R.M., García-Fernández, M.O., Clemente, C., Querol, M., Bellamy, F., Sanchez-Chapado, M., Prieto, J.C., Carmena, M.J. Prostate (2000) [Pubmed]
  6. Antiproliferative effect of Pygeum africanum extract on rat prostatic fibroblasts. Yablonsky, F., Nicolas, V., Riffaud, J.P., Bellamy, F. J. Urol. (1997) [Pubmed]
  7. Comparison of new topical treatments for herpes labialis: efficacy of penciclovir cream, acyclovir cream, and n-docosanol cream against experimental cutaneous herpes simplex virus type 1 infection. McKeough, M.B., Spruance, S.L. Archives of dermatology. (2001) [Pubmed]
  8. Comparison of finasteride (Proscar), a 5 alpha reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5 alpha reductase inhibition. Rhodes, L., Primka, R.L., Berman, C., Vergult, G., Gabriel, M., Pierre-Malice, M., Gibelin, B. Prostate (1993) [Pubmed]
  9. Clinical relevance of growth factor antagonists in the treatment of benign prostatic hyperplasia. Desgrandchamps, F. Eur. Urol. (1997) [Pubmed]
  10. A clinical and urodynamic study of tadenan in the treatment of benign prostatic hypertrophy. Donkervoort, T., Sterling, A., van Ness, J., Donker, P.J. Eur. Urol. (1977) [Pubmed]
  11. The toxicity of behenyl alcohol. II. Reproduction studies in rats and rabbits. Iglesias, G., Hlywka, J.J., Berg, J.E., Khalil, M.H., Pope, L.E., Tamarkin, D. Regulatory toxicology and pharmacology : RTP. (2002) [Pubmed]
  12. The toxicity of behenyl alcohol. I. Genotoxicity and subchronic toxicity in rats and dogs. Iglesias, G., Hlywka, J.J., Berg, J.E., Khalil, M.H., Pope, L.E., Tamarkin, D. Regulatory toxicology and pharmacology : RTP. (2002) [Pubmed]
  13. Cellular and molecular aspects of bladder hypertrophy. Levin, R.M., Levin, S.S., Zhao, Y., Buttyan, R. Eur. Urol. (1997) [Pubmed]
  14. The anti-herpes simplex virus activity of n-docosanol includes inhibition of the viral entry process. Pope, L.E., Marcelletti, J.F., Katz, L.R., Lin, J.Y., Katz, D.H., Parish, M.L., Spear, P.G. Antiviral Res. (1998) [Pubmed]
  15. The ultrastructure of the epithelium of bulbourethral glands after administration of the tadenan preparation. Latalski, M., Spruch, T., Obuchowska, D. Folia morphologica. (1979) [Pubmed]
  16. Synergistic inhibition of herpesvirus replication by docosanol and antiviral nucleoside analogs. Marcelletti, J.F. Antiviral Res. (2002) [Pubmed]
  17. Management of recurrent oral herpes simplex infections. Woo, S.B., Challacombe, S.J. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (2007) [Pubmed]
  18. Functional evaluation of Tadenan on micturition and experimental prostate growth induced with exogenous dihydrotestosterone. Choo, M.S., Bellamy, F., Constantinou, C.E. Urology (2000) [Pubmed]
  19. n-Docosanol 10% cream in the treatment of recurrent herpes labialis: a randomised, double-blind, placebo-controlled study. Habbema, L., De Boulle, K., Roders, G.A., Katz, D.H. Acta Derm. Venereol. (1996) [Pubmed]
  20. Efficacy and acceptability of tadenan (Pygeum africanum extract) in the treatment of benign prostatic hyperplasia (BPH): a multicentre trial in central Europe. Breza, J., Dzurny, O., Borowka, A., Hanus, T., Petrik, R., Blane, G., Chadha-Boreham, H. Current medical research and opinion. (1998) [Pubmed]
  21. Low-dose tadenan protects the rabbit bladder from bilateral ischemia/ reperfusion-induced contractile dysfunction. Levin, R.M., Whitbeck, C., Horan, P., Bellamy, F. Phytomedicine (2005) [Pubmed]
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