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MeSH Review


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Disease relevance of Urodynamics


Psychiatry related information on Urodynamics

  • The remaining 12 children with persistent NE and normal urodynamic findings and the child with DI and persistent NE empirically received DDAVP; enuresis ceased in all of them within 1 month and calciuria stabilized at normal levels [6].

High impact information on Urodynamics

  • The clinical status of SLE was determined according to the SLE Disease Activity Index (SLEDAI), and bladder function was evaluated by lower urinary tract symptoms and urodynamic studies [7].
  • Other less frequent features included neurological and psychiatric abnormalities, urodynamic abnormalities, limited joint motility, cardiovascular and gastrointestinal autonomic neuropathy, hypergonadotropic hypogonadism in males, and diabetic microvascular disease [8].
  • Here, we examine the in vivo urodynamic consequences and neurotransmitter dependence in the absence of the BK channel [9].
  • In contrast to true neurogenic bladder, findings of elongated, trabeculated, high-volume bladders with substantial postvoid residuals, obstructive uropathy, and vesicoureteral reflux were not associated with clinical, radiographic, or urodynamic evidence of an underlying neurologic abnormality [10].
  • Using pressure flow urodynamics, we evaluated the safety of tolterodine vs placebo in men with OAB and BOO [11].

Chemical compound and disease context of Urodynamics


Biological context of Urodynamics


Anatomical context of Urodynamics

  • Treatment with ephedrine sulfate prevented entry of urine into the proximal urethra and resulted in complete daytime continence, despite persisting urodynamic evidence of urethral and electromyographic abnormalities [22].
  • Based on the findings of external urethral sphincter spasm and/or pelvic floor hyperactivity the institution of diazepam therapy not only has provided clinical relief but also sphincter synergy as demonstrated by post-treaatment urodynamics [23].
  • The differences in urodynamic parameters between control and testosterone-treated rats could not be correlated with changes in bladder, urethral, or prostate excitatory innervation, as revealed by responses to electrical field stimulation, or by smooth muscle responses to different contractant drugs [24].
  • Duplication of the inferior vena cava in retrocaval ureter. A case of peroperative urodynamic investigation [25].
  • Frontal lobe disease may cause disorders of storage as well as voiding, as shown by urodynamics: detrusor hyperreflexia, detrusor areflexia, uninhibited sphincter relaxation and unrelaxing sphincter on voiding were found [26].

Associations of Urodynamics with chemical compounds

  • These patients were compared to those not using oxybutynin with regard to urodynamic parameters and upper tract deterioration [27].
  • CONCLUSIONS: Our results suggest that in humans there may be substantial differences in urodynamic effects between resiniferatoxin and capsaicin when the drugs are instilled into the bladder [28].
  • MATERIALS AND METHODS: A total of 20 Japanese patients 50 years old or older with symptomatic BPH underwent symptomatic and urodynamic evaluations, including pressure flow study, before and after terazosin treatment [29].
  • The effects of bethanechol chloride on urodynamic parameters in normal women and in women with significant residual urine volumes [30].
  • Of the 161 men 101 were reevaluated with a second clinical evaluation and urodynamics 1 to 5 years (mean 2) after watchful waiting in 20, medical treatment (alfuzosin 20 and finasteride 16) in 36 and surgery (transurethral incision of the prostate 13 and prostatectomy 32) in 45 [31].

Gene context of Urodynamics

  • The present work evaluates the effects of the COX-1/COX-2 inhibitor dexketoprofen as well as of a selective COX-2 inhibitor, NS-398, on urodynamic function following endotoxin (LPS) or cyclophosphamide (CYP)-induced inflammation of the urinary bladder [32].
  • METHODS: Female mice, both control and nNOS knockout, underwent voiding, urodynamic and muscle strip testing as well as histologic studies [33].
  • All patients underwent new CLPP measurement and a standard, complete urodynamic investigation, including filling cystometry with abdominal LPP and urethral pressure profile at rest [34].
  • RESULTS: There was no difference between unobstructed EP1KO and WT mice in urodynamic parameters but EP1KO mice did not respond to intravesical PGE2 instillation, while WT mice showed detrusor overactivity [35].
  • This study compared the effect of acute intravesical capsaicin administration on transvesical cystometries in urethane-anesthetized rats and hamsters, and aimed to assess whether sensory neuropeptides (tachykinins; calcitonin gene-related peptide, CGRP) play a role in the urodynamic effects of capsaicin in these species [36].

Analytical, diagnostic and therapeutic context of Urodynamics

  • Urodynamic effects of intravesical instillation of lidocaine in patients with overactive detrusor [37].
  • Medical management, based on clinical symptoms and urodynamic findings, incorporates clean intermittent catheterization, oral pharmacological agents (that is oral oxybutynin) or their combination (the desired end point of treatment being complete retention with clean intermittent catheterization) [38].
  • MATERIALS AND METHODS: This was a 4-week randomized, prospective, observational crossover study in 110 women with urodynamic stress incontinence (USI) or idiopathic detrusor overactivity (IDO) to determine the effect of caffeine restriction, and of increasing and decreasing fluid intake on urinary symptoms [39].
  • Total and segmental colonic transit were studied by determination of radiopaque markers, and anorectal function by anorectal manometry, in 16 multiple sclerosis patients clinically defined (with urinary bladder dysfunction shown by urodynamic examination) [40].
  • Twenty-six women (aged 26 to 60) with stress incontinence underwent urodynamic investigation before and after oral administration of 5 mg of midodrine, a new adrenergic agent with alpha-stimulant activity [41].


  1. Is sphincterotomy the best management of the spinal cord injured bladder? Vapnek, J.M., Couillard, D.R., Stone, A.R. J. Urol. (1994) [Pubmed]
  2. Long-term results of sacral nerve stimulation (S3) for the treatment of neurogenic refractory urge incontinence related to detrusor hyperreflexia. Chartier-Kastler, E.J., Ruud Bosch, J.L., Perrigot, M., Chancellor, M.B., Richard, F., Denys, P. J. Urol. (2000) [Pubmed]
  3. Effect of naftopidil on urethral obstruction in benign prostatic hyperplasia: assessment by urodynamic studies. Yasuda, K., Yamanishi, T., Tojo, M., Nagashima, K., Akimoto, S., Shimazaki, J. Prostate (1994) [Pubmed]
  4. The effects of intravesical lidocaine on bladder dynamics of children with myelomeningocele. Lapointe, S.P., Wang, B., Kennedy, W.A., Shortliffe, L.M. J. Urol. (2001) [Pubmed]
  5. Randomized trial of antibiotic prophylaxis for combined urodynamics and cystourethroscopy. Cundiff, G.W., McLennan, M.T., Bent, A.E. Obstetrics and gynecology. (1999) [Pubmed]
  6. Nocturnal enuresis can be caused by absorptive hypercalciuria. Pace, G., Aceto, G., Cormio, L., Traficante, A., Tempesta, A., Lospalluti, M.L., Selvaggi, F.P., Penza, R. Scandinavian journal of urology and nephrology. (1999) [Pubmed]
  7. Voiding dysfunction in women with systemic lupus erythematosus. Yu, H.J., Lee, W.C., Lee, K.L., Chen, M.Y., Chen, C.Y., Chen, J. Arthritis Rheum. (2004) [Pubmed]
  8. Diabetes mellitus and optic atrophy: a study of Wolfram syndrome in the Lebanese population. Medlej, R., Wasson, J., Baz, P., Azar, S., Salti, I., Loiselet, J., Permutt, A., Halaby, G. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  9. Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. Thorneloe, K.S., Meredith, A.L., Knorn, A.M., Aldrich, R.W., Nelson, M.T. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  10. Distention of the posterior urethra: association with nonneurogenic neurogenic bladder (Hinman syndrome). Johnson, J.F., Hedden, R.J., Piccolello, M.L., Wacksman, J. Radiology. (1992) [Pubmed]
  11. Safety and tolerability of tolterodine for the treatment of overactive bladder in men with bladder outlet obstruction. Abrams, P., Kaplan, S., De Koning Gans, H.J., Millard, R. J. Urol. (2006) [Pubmed]
  12. Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia. Kaplan, S.A. J. Urol. (2005) [Pubmed]
  13. Comparison of darifenacin and oxybutynin in patients with overactive bladder: assessment of ambulatory urodynamics and impact on salivary flow. Chapple, C.R., Abrams, P. Eur. Urol. (2005) [Pubmed]
  14. Effects of short-term treatment with the alpha 1-blocker alfuzosin on urodynamic pressure/flow parameters in patients with benign prostatic hyperplasia. Martorana, G., Giberti, C., Di Silverio, F., von Heland, M., Rigatti, P., Colombo, R., Casadei, G., Pacifico, P. Eur. Urol. (1997) [Pubmed]
  15. Postmenopausal urinary incontinence: comparison between non-estrogen-supplemented and estrogen-supplemented women. Fantl, J.A., Wyman, J.F., Anderson, R.L., Matt, D.W., Bump, R.C. Obstetrics and gynecology. (1988) [Pubmed]
  16. Voiding dysfunction in patients with spastic paraplegia: urodynamic evaluation and response to continuous intrathecal baclofen. Bushman, W., Steers, W.D., Meythaler, J.M. Neurourology and urodynamics. (1993) [Pubmed]
  17. Infravesical obstruction in aromatase over expressing transgenic male mice with increased ratio of serum estrogen-to-androgen concentration. Streng, T., Li, X., Lehtoranta, M., Mäkelä, S., Poutanen, M., Talo, A., Tekmal, R.R., Santti, R. J. Urol. (2002) [Pubmed]
  18. The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions. Komersova, K., Rogerson, J.W., Conway, E.L., Lim, T.C., Brown, D.J., Krum, H., Jackman, G.P., Murdoch, R., Louis, W.J. British journal of clinical pharmacology. (1995) [Pubmed]
  19. The absence and effect of induced menopause by gonadotropin-releasing hormone analogs on lower urinary tract symptoms and urodynamic parameters. Langer, R., Golan, A., Neuman, M., Pansky, M., Bukovsky, I., Caspi, E. Fertil. Steril. (1991) [Pubmed]
  20. Position-related changes in voiding dynamics in men. Riehmann, M., Bayer, W.H., Drinka, P.J., Schultz, S., Krause, P., Rhodes, P.R., Heisey, D., Bruskewitz, R.C. Urology (1998) [Pubmed]
  21. Long-term results of subtotal colectomy and evidence of noncolonic involvement in patients with idiopathic slow-transit constipation. Ghosh, S., Papachrysostomou, M., Batool, M., Eastwood, M.A. Scand. J. Gastroenterol. (1996) [Pubmed]
  22. Central nervous system lesion causing urethral instability and urinary incontinence. Woodside, J.R., Borden, T.A. J. Urol. (1983) [Pubmed]
  23. The female urethral syndrome: external sphincter spasm as etiology. Kaplan, W.E., Firlit, C.F., Schoenberg, H.W. J. Urol. (1980) [Pubmed]
  24. Testosterone-induced prostatic growth in the rat causes bladder overactivity unrelated to detrusor hypertrophy. Pandita, R.K., Persson, K., Hedlund, P., Andersson, K.E. Prostate (1998) [Pubmed]
  25. Duplication of the inferior vena cava in retrocaval ureter. A case of peroperative urodynamic investigation. Djurhuus, J.C., Efsen, F., Nerstrom, B. Acta chirurgica Scandinavica. Supplementum. (1976) [Pubmed]
  26. Voiding and MRI analysis of the brain. Sakakibara, R., Fowler, C.J., Hattori, T. International urogynecology journal and pelvic floor dysfunction. (1999) [Pubmed]
  27. The role of oxybutynin in spinal cord injured patients with indwelling catheters. Kim, Y.H., Bird, E.T., Priebe, M., Boone, T.B. J. Urol. (1997) [Pubmed]
  28. Urodynamic effects of intravesical resiniferatoxin in humans: preliminary results in stable and unstable detrusor. Lazzeri, M., Beneforti, P., Turini, D. J. Urol. (1997) [Pubmed]
  29. Urodynamic effects of terazosin treatment for Japanese patients with symptomatic benign prostatic hyperplasia. Tanaka, Y., Masumori, N., Itoh, N., Sato, Y., Takahashi, A., Ogura, H., Furuya, S., Tsukamoto, T. J. Urol. (2002) [Pubmed]
  30. The effects of bethanechol chloride on urodynamic parameters in normal women and in women with significant residual urine volumes. Wein, A.J., Malloy, T.R., Shofer, F., Raezer, D.M. J. Urol. (1980) [Pubmed]
  31. The evolution of detrusor overactivity after watchful waiting, medical therapy and surgery in patients with bladder outlet obstruction. de Nunzio, C., Franco, G., Rocchegiani, A., Iori, F., Leonardo, C., Laurenti, C. J. Urol. (2003) [Pubmed]
  32. Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats. Lecci, A., Birder, L.A., Meini, S., Catalioto, R.M., Tramontana, M., Giuliani, S., Criscuoli, M., Maggi, C.A. Br. J. Pharmacol. (2000) [Pubmed]
  33. Vesicourethral function in mice with genetic disruption of neuronal nitric oxide synthase. Sutherland, R.S., Kogan, B.A., Piechota, H.J., Bredt, D.S. J. Urol. (1997) [Pubmed]
  34. Evaluation of minimally invasive analysis system for cough leak point pressure measurement. Kocjancic, E., Tarrano, E., Panella, M., Crivellaro, S., Smith, J.J., Maso, G., Favro, M., Ceratti, G., Gontero, P., Frea, B. J. Urol. (2004) [Pubmed]
  35. Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice. Schröder, A., Newgreen, D., Andersson, K.E. J. Urol. (2004) [Pubmed]
  36. Urodynamic effects induced by intravesical capsaicin in rats and hamsters. Lecci, A., Carini, F., Tramontana, M., Birder, L.A., de Groat, W.C., Santicioli, P., Giuliani, S., Maggi, C.A. Autonomic neuroscience : basic & clinical. (2001) [Pubmed]
  37. Urodynamic effects of intravesical instillation of lidocaine in patients with overactive detrusor. Yokoyama, O., Ishiura, Y., Nakamura, Y., Kunimi, K., Mita, E., Namiki, M. J. Urol. (1997) [Pubmed]
  38. Role of limited evaluation and aggressive medical management in multiple sclerosis: a review of 113 patients. Sirls, L.T., Zimmern, P.E., Leach, G.E. J. Urol. (1994) [Pubmed]
  39. The effect of fluid intake on urinary symptoms in women. Swithinbank, L., Hashim, H., Abrams, P. J. Urol. (2005) [Pubmed]
  40. Radiopaque markers transit and anorectal manometry in 16 patients with multiple sclerosis and urinary bladder dysfunction. Weber, J., Grise, P., Roquebert, M., Hellot, M.F., Mihout, B., Samson, M., Beuret-Blanquart, F., Pasquis, P., Denis, P. Dis. Colon Rectum (1987) [Pubmed]
  41. Midodrine for female incontinence: a preliminary report. Garofalo, F., Lalanne, G.M., Nanni, G. Clinical therapeutics. (1986) [Pubmed]
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