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MeSH Review

Gastrodia

 
 
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High impact information on Gastrodia

  • Two isoforms of an antifungal protein, gastrodianin, were isolated from two subspecies of the orchid Gastrodia elata, belonging to the protein superfamily of monocot mannose-specific lectins [1].
  • Gastrodin is one of the natural compound isolated from Gastrodia elata and has known anticonvulsant effects, although the exact pharmacological principles of this natural compound and its effects on other aspects of gamma-aminobutyric acid (GABA) metabolism in vivo have not been explored [2].
  • We examined the antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol (p-HBA), the major component of Gastrodia elata Bl [3].
  • Preparative isolation and purification of gastrodin from the Chinese medicinal plant Gastrodia elata by high-speed counter-current chromatography [4].
  • A plant antifungal protein, Gastrodia antifungal protein (GAFP-1) has been isolated from terminal corms of the orchid Gastrodia elata B1 f. elata, purified to homogeneity and crystallized by means of the hanging-drop vapour-diffusion method [5].
 

Associations of Gastrodia with chemical compounds

 

Analytical, diagnostic and therapeutic context of Gastrodia

References

  1. Structural mechanism governing the quaternary organization of monocot mannose-binding lectin revealed by the novel monomeric structure of an orchid lectin. Liu, W., Yang, N., Ding, J., Huang, R.H., Hu, Z., Wang, D.C. J. Biol. Chem. (2005) [Pubmed]
  2. Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils. An, S.J., Park, S.K., Hwang, I.K., Choi, S.Y., Kim, S.K., Kwon, O.S., Jung, S.J., Baek, N.I., Lee, H.Y., Won, M.H., Kang, T.C. J. Neurosci. Res. (2003) [Pubmed]
  3. Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects on free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA. Liu, J., Mori, A. Neuropharmacology (1993) [Pubmed]
  4. Preparative isolation and purification of gastrodin from the Chinese medicinal plant Gastrodia elata by high-speed counter-current chromatography. Li, H.B., Chen, F. Journal of chromatography. A. (2004) [Pubmed]
  5. Purification, crystallization and preliminary X-ray diffraction analysis of a novel mannose-binding lectin from Gastrodia elata with antifungal properties. Liu, W., Hu, Y.L., Wang, M., Xiang, Y., Hu, Z., Wang, D.C. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
  6. Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia. Andersson, M., Bergendorff, O., Nielsen, M., Sterner, O., Witt, R., Ai, J., Lu, A., Wang, A.M. Phytochemistry (1995) [Pubmed]
  7. Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats. Hsieh, C.L., Chang, C.H., Chiang, S.Y., Li, T.C., Tang, N.Y., Pon, C.Z., Hsieh, C.T., Lin, J.G. Life Sci. (2000) [Pubmed]
  8. The promoter of an antifungal protein gene from Gastrodia elata confers tissue -specific and fungus-inducible expression patterns and responds to both salicylic acid and jasmonic acid. Sa, Q., Wang, Y., Li, W., Zhang, L., Sun, Y. Plant Cell Rep. (2003) [Pubmed]
  9. Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation. Hayashi, J., Sekine, T., Deguchi, S., Lin, Q., Horie, S., Tsuchiya, S., Yano, S., Watanabe, K., Ikegami, F. Phytochemistry (2002) [Pubmed]
  10. 4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain. Ha, J.H., Lee, D.U., Lee, J.T., Kim, J.S., Yong, C.S., Kim, J.A., Ha, J.S., Huh, K. Journal of ethnopharmacology. (2000) [Pubmed]
  11. Gastrodia elata BL mediates the suppression of nNOS and microglia activation to protect against neuronal damage in kainic acid-treated rats. Hsieh, C.L., Chen, C.L., Tang, N.Y., Chuang, C.M., Hsieh, C.T., Chiang, S.Y., Lin, J.G., Hsu, S.F. Am. J. Chin. Med. (2005) [Pubmed]
 
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