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Chemical Compound Review

Gastrodin     (2R,3S,4S,5R,6S)-2- (hydroxymethyl)-6-[4...

Synonyms: Gastrodine, S2383_Selleck, CHEMBL274739, Bio-0293, SureCN1076037, ...
 
 
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Disease relevance of Gastrodine

 

Psychiatry related information on Gastrodine

 

High impact information on Gastrodine

 

Associations of Gastrodine with other chemical compounds

 

Analytical, diagnostic and therapeutic context of Gastrodine

  • This assay has been successfully used to provide pharmacokinetic data for Gastrodin with oral administration of Tianxiong capsules [4].
  • Simultaneous determination of gastrodin and its metabolite by HPLC [7].
  • In our search for the anticonvulsant constituent of Gastrodia elata repeated column chromatographies guided by activity assay led to isolation of an active compound, which was identified as gastrodin on the basis of spectral data [8].

References

  1. A Study of the Neuroprotective Effect of the Phenolic Glucoside Gastrodin during Cerebral Ischemia in vivo and in vitro. Zeng, X., Zhang, S., Zhang, L., Zhang, K., Zheng, X. Planta Med. (2006) [Pubmed]
  2. Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Bie, X., Chen, Y., Han, J., Dai, H., Wan, H., Zhao, T. Asia Pacific journal of clinical nutrition (2007) [Pubmed]
  3. Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils. An, S.J., Park, S.K., Hwang, I.K., Choi, S.Y., Kim, S.K., Kwon, O.S., Jung, S.J., Baek, N.I., Lee, H.Y., Won, M.H., Kang, T.C. J. Neurosci. Res. (2003) [Pubmed]
  4. Simultaneous determination of Gastrodin and Ligustrazine hydrochloride in dog plasma by gradient high-performance liquid chromatography. Li, L.L., Zhang, Z.R., Gong, T., He, L.L., Deng, L. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  5. Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats. Hsieh, M.T., Wu, C.R., Chen, C.F. Journal of ethnopharmacology. (1997) [Pubmed]
  6. p-Hydroxybenzyl alcohol attenuates learning deficits in the inhibitory avoidance task: involvement of serotonergic and dopaminergic systems. Wu, C.R., Hsieh, M.T., Liao, J. The Chinese journal of physiology. (1996) [Pubmed]
  7. Simultaneous determination of gastrodin and its metabolite by HPLC. Liu, K.X., Han, G.Z., Chang, Y.L., Su, C.Y., Tang, N.Y., Chen, Y.R. Biomed. Chromatogr. (1987) [Pubmed]
  8. Isolation and identification of succinic semialdehyde dehydrogenase inhibitory compound from the rhizome of Gastrodia elata Blume. Baek, N.I., Choi, S.Y., Park, J.K., Cho, S.W., Ahn, E.M., Jeon, S.G., Lee, B.R., Bahn, J.H., Kim, Y.K., Shon, I.H. Arch. Pharm. Res. (1999) [Pubmed]
 
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