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Chemical Compound Review:

Gastrodin (2R,3S,4S,5R,6S)-2- (hydroxymethyl)-6-[4...

Synonyms: Gastrodine, S2383_Selleck, CHEMBL274739, Bio-0293, SureCN1076037, ...

Bie, X. et al., Zeng, X. et al., Li, L.L. et al., Baek, N.I. et al., An, S.J. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gastrodine

A Study of the Neuroprotective Effect of the Phenolic Glucoside Gastrodin during Cerebral Ischemia in vivo and in vitro [1].
Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum [2].
This study showed that gastrodin can decrease the volume of cerebral infarction, ameliorate the cerebral injury in the rats of cerebral ischemia-reperfusion [2].

Psychiatry related information on Gastrodine

The phenolic glucoside gastrodin (Gas) is a main component extracted from the rhizome of GASTRODIA ELATA, a Chinese herbal medicine, which has long been used for treating dizziness, epilepsy, stroke and dementia [1].

High impact information on Gastrodine

Interestingly, in the gastrodin-treated group, GABA transaminase (GABA-T) immunoreactivity in the hippocampus, particularly in neurons, was significantly decreased [3].
Simultaneous determination of Gastrodin and Ligustrazine hydrochloride in dog plasma by gradient high-performance liquid chromatography [4].
30 male SD rats were randomly divided into 3 groups: the group of pseudo-operation (normal control group, NC group), the group of cerebral ischemia-reperfusion injury (CIRI group), and the group of cerebral ischemia-reperfusion injury treated with gastrodin (G group) [2].
Gastrodin (GAS) and p-hydroxybenzyl alcohol (HBA) which is an aglycone of gastrodin, are active ingredients of Gastrodia elata Blume [5].

Associations of Gastrodine with other chemical compounds

p-Hydroxybenzyl alcohol (HBA), an aglycone of gastrodin, is an active ingredient of Gastrodia elata BLUME [6].

Analytical, diagnostic and therapeutic context of Gastrodine

This assay has been successfully used to provide pharmacokinetic data for Gastrodin with oral administration of Tianxiong capsules [4].
Simultaneous determination of gastrodin and its metabolite by HPLC [7].
In our search for the anticonvulsant constituent of Gastrodia elata repeated column chromatographies guided by activity assay led to isolation of an active compound, which was identified as gastrodin on the basis of spectral data [8].

References

A Study of the Neuroprotective Effect of the Phenolic Glucoside Gastrodin during Cerebral Ischemia in vivo and in vitro. Zeng, X., Zhang, S., Zhang, L., Zhang, K., Zheng, X. Planta Med. (2006) [Pubmed]
Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Bie, X., Chen, Y., Han, J., Dai, H., Wan, H., Zhao, T. Asia Pacific journal of clinical nutrition (2007) [Pubmed]
Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils. An, S.J., Park, S.K., Hwang, I.K., Choi, S.Y., Kim, S.K., Kwon, O.S., Jung, S.J., Baek, N.I., Lee, H.Y., Won, M.H., Kang, T.C. J. Neurosci. Res. (2003) [Pubmed]
Simultaneous determination of Gastrodin and Ligustrazine hydrochloride in dog plasma by gradient high-performance liquid chromatography. Li, L.L., Zhang, Z.R., Gong, T., He, L.L., Deng, L. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats. Hsieh, M.T., Wu, C.R., Chen, C.F. Journal of ethnopharmacology. (1997) [Pubmed]
p-Hydroxybenzyl alcohol attenuates learning deficits in the inhibitory avoidance task: involvement of serotonergic and dopaminergic systems. Wu, C.R., Hsieh, M.T., Liao, J. The Chinese journal of physiology. (1996) [Pubmed]
Simultaneous determination of gastrodin and its metabolite by HPLC. Liu, K.X., Han, G.Z., Chang, Y.L., Su, C.Y., Tang, N.Y., Chen, Y.R. Biomed. Chromatogr. (1987) [Pubmed]
Isolation and identification of succinic semialdehyde dehydrogenase inhibitory compound from the rhizome of Gastrodia elata Blume. Baek, N.I., Choi, S.Y., Park, J.K., Cho, S.W., Ahn, E.M., Jeon, S.G., Lee, B.R., Bahn, J.H., Kim, Y.K., Shon, I.H. Arch. Pharm. Res. (1999) [Pubmed]

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