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Gene Review

RAB11FIP5  -  RAB11 family interacting protein 5 (class I)

Homo sapiens

Synonyms: GAF1, Gaf-1, Gamma-SNAP-associated factor 1, KIAA0857, Phosphoprotein pp75, ...
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Disease relevance of RAB11FIP5


High impact information on RAB11FIP5


Biological context of RAB11FIP5

  • The open reading frame of Gaf1 predicts a protein of Mr 32 kDa consisting of 290 intronless amino acids [5].
  • These results demonstrate that Gaf1 may function as a transcriptional activator consisting of DNA-binding and transactivation domains [5].
  • The predicted amino acid (aa) sequence of Gaf1 reveals a single zinc finger domain typical of fungal GATA factors, and the zinc finger exhibits 60% aa identity to that of human GATA-1 [5].

Anatomical context of RAB11FIP5


Associations of RAB11FIP5 with chemical compounds


Physical interactions of RAB11FIP5

  • This binding is distinct from other SNAP interactions since no alpha-SNAP or NSF coprecipitated with Gaf-1 [7].

Other interactions of RAB11FIP5

  • Our two-hybrid analysis revealed that gamma-SNAP, unlike alpha-SNAP, interacts directly with NSF, as well as Gaf-1/Rip11, but not with SNAREs [4].
  • RCP is a homologue of Rip11 and therefore belongs to the recently described Rab11-FIP family [9].
  • We now demonstrate that two of the family members-pp75/Rip11 and Rab11-FIP3 do not bind Rab4 and show that several members of the family can self-interact and interact with each other [10].

Analytical, diagnostic and therapeutic context of RAB11FIP5


  1. Specific phosphorylation by calcium-EGTA complex of a 75 kDa human tumor plasma membrane protein (pp75). Ziai, M.R., Ferrone, S. Int. J. Biochem. (1989) [Pubmed]
  2. A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Prekeris, R., Klumperman, J., Scheller, R.H. Mol. Cell (2000) [Pubmed]
  3. Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies. Wang, D., Buyon, J.P., Zhu, W., Chan, E.K. J. Clin. Invest. (1999) [Pubmed]
  4. Mapping of functional domains of gamma-SNAP. Tani, K., Shibata, M., Kawase, K., Kawashima, H., Hatsuzawa, K., Nagahama, M., Tagaya, M. J. Biol. Chem. (2003) [Pubmed]
  5. Molecular cloning of gaf1, a Schizosaccharomyces pombe GATA factor, which can function as a transcriptional activator. Hoe, K.L., Won, M.S., Chung, K.S., Park, S.K., Kim, D.U., Jang, Y.J., Yoo, O.J., Yoo, H.S. Gene (1998) [Pubmed]
  6. Gaf-1b is an alternative splice variant of Gaf-1/Rip11. Kawase, K., Shibata, M., Kawashima, H., Hatsuzawa, K., Nagahama, M., Tagaya, M., Tani, K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  7. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. Chen, D., Xu, W., He, P., Medrano, E.E., Whiteheart, S.W. J. Biol. Chem. (2001) [Pubmed]
  8. Infection with Chlamydia trachomatis alters the tyrosine phosphorylation and/or localization of several host cell proteins including cortactin. Fawaz, F.S., van Ooij, C., Homola, E., Mutka, S.C., Engel, J.N. Infect. Immun. (1997) [Pubmed]
  9. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. Lindsay, A.J., Hendrick, A.G., Cantalupo, G., Senic-Matuglia, F., Goud, B., Bucci, C., McCaffrey, M.W. J. Biol. Chem. (2002) [Pubmed]
  10. The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. Wallace, D.M., Lindsay, A.J., Hendrick, A.G., McCaffrey, M.W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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