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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

F-Box Motifs

 
 
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High impact information on F-Box Motifs

  • We cloned SON1 and found it to encode a novel protein containing an F-box motif, an element found within the specificity determinant in the E3 ubiquitin-ligase complex [1].
  • Map-based cloning of ORE9 identified a 693-amino acid polypeptide containing an F-box motif and 18 leucine-rich repeats [2].
  • Rapid destruction of cyclin F does not require the N-terminal F-box motif but requires the COOH-terminal PEST sequences [3].
  • In addition, the chimerical proteins with swapped domain of the F-box motif or LRR between GmCOI1 and COI1 were shown to functionally complement the coil-1 mutation [4].
  • However, the most interesting and surprising finding in this work was that the related RH proteins carry an F-box motif [5].
 

Associations of F-Box Motifs with chemical compounds

  • In this study, we isolated an F-box protein gene from soybean, which shares significant homology with the Arabidopsis COI1 and similarly contains an F-box motif and leucine rich repeats (LRR), here designated GmCOI1 (Glycine max L. (Merr.) COI1) [4].
 

Gene context of F-Box Motifs

  • F-box proteins bind Skp1 through the F-box motif, and substrates by means of carboxy-terminal protein interaction domains [6].
  • The F-box motif of the At5g48990 gene product, a member of the family, was shown to be functionally active by its ability to mediate the in vitro interaction between At5g48990 and ASK1 proteins [7].
  • Interaction with components of the SCF complex is mediated through the F-box motif of the F-box protein while it associates with phosphorylated substrates through its second protein-protein interaction motif such as Trp-Asp (WD) repeats or leucine-rich repeats (LRRs) [8].

References

  1. Arabidopsis SON1 is an F-box protein that regulates a novel induced defense response independent of both salicylic acid and systemic acquired resistance. Kim, H.S., Delaney, T.P. Plant Cell (2002) [Pubmed]
  2. ORE9, an F-box protein that regulates leaf senescence in Arabidopsis. Woo, H.R., Chung, K.M., Park, J.H., Oh, S.A., Ahn, T., Hong, S.H., Jang, S.K., Nam, H.G. Plant Cell (2001) [Pubmed]
  3. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. Fung, T.K., Siu, W.Y., Yam, C.H., Lau, A., Poon, R.Y. J. Biol. Chem. (2002) [Pubmed]
  4. GmCOI1, a soybean F-box protein gene, shows ability to mediate jasmonate-regulated plant defense and fertility in Arabidopsis. Wang, Z., Dai, L., Jiang, Z., Peng, W., Zhang, L., Wang, G., Xie, D. Mol. Plant Microbe Interact. (2005) [Pubmed]
  5. Identification of a unique family of F-box proteins in atadenoviruses. Both, G.W. Virology (2002) [Pubmed]
  6. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J., Harper, J.W. Nature (2003) [Pubmed]
  7. A combination of the F-box motif and kelch repeats defines a large Arabidopsis family of F-box proteins. Andrade, M.A., González-Guzmán, M., Serrano, R., Rodríguez, P.L. Plant Mol. Biol. (2001) [Pubmed]
  8. F-box proteins: the key to protein degradation. Ho, M.S., Tsai, P.I., Chien, C.T. J. Biomed. Sci. (2006) [Pubmed]
 
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