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Gene Review

AT2G12200  -  P-loop containing nucleoside triphosphate...

Arabidopsis thaliana

Synonyms: T10J7.18, T10J7_18
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Disease relevance of AT2G12200

  • Surprisingly, functional 2'-phosphotransferase is found also in the bacterium Escherichia coli, which does not have any known introns of this class, and does not appear to have a ligase that generates junctions with a 2'-phosphate [1].
  • Here, the crystal structure of the 2'-5' RNA ligase protein from an extreme thermophile, Thermus thermophilus HB8, was solved at 2.5A resolution [2].

High impact information on AT2G12200


Biological context of AT2G12200

  • Autonomous Helitrons encode a 5'-to-3' DNA helicase and nuclease/ligase similar to those encoded by known rolling-circle replicons [8].
  • These data suggest that the E3 ubiquitin ligase AtCHIP may function upstream of PP2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark [9].
  • The Phl protein contained most of the amino acids defining the aryl-CoA (4-coumaroyl-CoA) ligase substrate-specificity code and differed from acetyl-CoA ligase and other acyl-CoA ligases [10].
  • The specificity of the reaction is controlled by an ubiquitin-ligase multiprotein complex known as APC (Anaphase Promoting Complex) [11].

Anatomical context of AT2G12200

  • Here we show that phytochrome (phy) A, a predominant photoreceptor for seedling deetiolation, colocalizes in nuclear bodies with CONSTITUTIVELY PHOTOMORPHOGENIC (COP) 1, a RING motif-containing E3 ligase [4].
  • Heterologous expression of a plant uracil transporter in yeast: improvement of plasma membrane targeting in mutants of the Rsp5p ubiquitin protein ligase [12].

Associations of AT2G12200 with chemical compounds


Other interactions of AT2G12200


Analytical, diagnostic and therapeutic context of AT2G12200


  1. A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli. Spinelli, S.L., Malik, H.S., Consaul, S.A., Phizicky, E.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Crystal structure of the 2'-5' RNA ligase from Thermus thermophilus HB8. Kato, M., Shirouzu, M., Terada, T., Yamaguchi, H., Murayama, K., Sakai, H., Kuramitsu, S., Yokoyama, S. J. Mol. Biol. (2003) [Pubmed]
  3. Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins. Gray, W.M., Kepinski, S., Rouse, D., Leyser, O., Estelle, M. Nature (2001) [Pubmed]
  4. Photoreceptor ubiquitination by COP1 E3 ligase desensitizes phytochrome A signaling. Seo, H.S., Watanabe, E., Tokutomi, S., Nagatani, A., Chua, N.H. Genes Dev. (2004) [Pubmed]
  5. Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana. Gray, W.M., del Pozo, J.C., Walker, L., Hobbie, L., Risseeuw, E., Banks, T., Crosby, W.L., Yang, M., Ma, H., Estelle, M. Genes Dev. (1999) [Pubmed]
  6. The U-box protein CMPG1 is required for efficient activation of defense mechanisms triggered by multiple resistance genes in tobacco and tomato. González-Lamothe, R., Tsitsigiannis, D.I., Ludwig, A.A., Panicot, M., Shirasu, K., Jones, J.D. Plant Cell (2006) [Pubmed]
  7. KEEP ON GOING, a RING E3 Ligase Essential for Arabidopsis Growth and Development, Is Involved in Abscisic Acid Signaling. Stone, S.L., Williams, L.A., Farmer, L.M., Vierstra, R.D., Callis, J. Plant Cell (2006) [Pubmed]
  8. Rolling-circle transposons in eukaryotes. Kapitonov, V.V., Jurka, J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. AtCHIP functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatment. Luo, J., Shen, G., Yan, J., He, C., Zhang, H. Plant J. (2006) [Pubmed]
  10. Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase. Lamas-Maceiras, M., Vaca, I., Rodríguez, E., Casqueiro, J., Martín, J.F. Biochem. J. (2006) [Pubmed]
  11. The Arabidopsis anaphase promoting complex (APC): regulation through subunit availability in plant tissues. Eloy, N.B., Coppens, F., Beemster, G.T., Hemerly, A.S., Ferreira, P.C. Cell Cycle (2006) [Pubmed]
  12. Heterologous expression of a plant uracil transporter in yeast: improvement of plasma membrane targeting in mutants of the Rsp5p ubiquitin protein ligase. Froissard, M., Belgareh-Touzé, N., Buisson, N., Desimone, M., Frommer, W.B., Haguenauer-Tsapis, R. Biotechnology journal. (2006) [Pubmed]
  13. The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Xu, L., Liu, F., Lechner, E., Genschik, P., Crosby, W.L., Ma, H., Peng, W., Huang, D., Xie, D. Plant Cell (2002) [Pubmed]
  14. Molecular characterization of the non-biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase. McKean, A.L., Ke, J., Song, J., Che, P., Achenbach, S., Nikolau, B.J., Wurtele, E.S. J. Biol. Chem. (2000) [Pubmed]
  15. Salicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase. Lee, J., Nam, J., Park, H.C., Na, G., Miura, K., Jin, J.B., Yoo, C.Y., Baek, D., Kim, D.H., Jeong, J.C., Kim, D., Lee, S.Y., Salt, D.E., Mengiste, T., Gong, Q., Ma, S., Bohnert, H.J., Kwak, S.S., Bressan, R.A., Hasegawa, P.M., Yun, D.J. Plant J. (2007) [Pubmed]
  16. COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis. Devoto, A., Nieto-Rostro, M., Xie, D., Ellis, C., Harmston, R., Patrick, E., Davis, J., Sherratt, L., Coleman, M., Turner, J.G. Plant J. (2002) [Pubmed]
  17. Genetic interactions of a putative Arabidopsis thaliana ubiquitin-ligase with components of the Saccharomyces cerevisiae ubiquitination machinery. Aguilar-Henonin, L., Bravo, J., Guzmán, P. Curr. Genet. (2006) [Pubmed]
  18. Purification and sequence determination of an RNA ligase from wheat embryos. Makino, S., Sawasaki, T., Endo, Y., Takai, K. Nucleic acids symposium series (2004) (2005) [Pubmed]
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