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MeSH Review:

Rabies

Weihrauch, T.R. et al., Singh, J. et al., Warrell, D.A.

Singh, Jain, Bhatia, Ichhpujani, Harit, Panda, Tewari, Sokhey,

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Disease relevance of Rabies

METHODS: Analysis of the records of hydrophobia cases admitted to the Infectious Diseases Hospital, Delhi (IDH) in 1998 [1].

High impact information on Rabies

With increasing hydrophobia the neurotoxic potency increased in the following sequence: Ticarcillin, methicillin, oxacillin, phenethicillin, cloxacillin, dicloxacillin [2].
The hydrophobia of the penicillins was characterized by determination of their partition coefficients between isobutanol and buffer solution pH 7 [2].
In a minority of cases hydrophobia develops before the terminal coma [3].
RESULTS: About 46 percent (99/215) of the hydrophobia cases admitted to the IDH in 1998 belonged to Delhi [1].

References

Epidemiological characteristics of rabies in Delhi and surrounding areas, 1998. Singh, J., Jain, D.C., Bhatia, R., Ichhpujani, R.L., Harit, A.K., Panda, R.C., Tewari, K.N., Sokhey, J. Indian pediatrics. (2001) [Pubmed]
Cerebral toxicity of penicillins in relation to their hydrophobic character. Weihrauch, T.R., Köhler, H., Höffler, D. Naunyn Schmiedebergs Arch. Pharmacol. (1975) [Pubmed]
The clinical picture of rabies in man. Warrell, D.A. Trans. R. Soc. Trop. Med. Hyg. (1976) [Pubmed]

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