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MeSH Review:

Cochlear Microphonic Potentials

Takada, A. et al., Rebillard, G. et al., Nuttall, A.L. et al., Russell, I.J. et al., Takada, A. et al., et al.

Russell, Drexl, Foeller, Vater, Kössl,

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High impact information on Cochlear Microphonic Potentials

Only intracochlear perfusions with l-trans-pyrrolidine-2,4-dicarboxylic acid resulted in a dose-dependent decrease in the amplitude of the cochlear compound action potential, leaving cochlear microphonic potential unaffected [1].
In contrast, the monomeric L-lysine had only slight effects on polyphosphoinositide monolayers and did not affect cochlear microphonic potentials even at concentrations as high as 10 mM [2].
Low concentrations of poly-L-lysine, a polycationic hydrophilic molecule, caused a large expansion of polyphosphoinositide monolayers and produced a significant loss of cochlear microphonic potentials in perilymphatic perfusions in the guinea pig [2].
Cochlear microphonic potentials (CMs) were recorded from the sharply tuned, strongly resonant auditory foveae of 1- to 5-week-old mustached bats that were anesthetized with Rompun and Ketavet [3].
A previous study showed that systemic administration of erythromycin caused a reversible decline in the endocochlear and cochlear microphonic potentials [4].

Anatomical context of Cochlear Microphonic Potentials

The effects of three concentrations of neomycin, administered by a method of acute perilymphatic perfusion of the guinea pig cochlea, on the cochlear microphonic potential (CM) at 4 kHz and 500 Hz are described [5].

Associations of Cochlear Microphonic Potentials with chemical compounds

The hypothesis was tested that gentamicin causes loss of cochlear microphonic potentials by interfering with glucose transport or metabolism in cochlear structures [6].

References

Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications. Rebillard, G., Ruel, J., Nouvian, R., Saleh, H., Pujol, R., Dehnes, Y., Raymond, J., Puel, J.L., Devau, G. Eur. J. Neurosci. (2003) [Pubmed]
Lysine and polylysine: correlation of their effects on polyphosphoinositides in vitro with ototoxic action in vivo. Takada, A., Lodhi, S., Weiner, N.D., Schacht, J. Journal of pharmaceutical sciences. (1982) [Pubmed]
The development of a single frequency place in the mammalian cochlea: the cochlear resonance in the mustached bat Pteronotus parnellii. Russell, I.J., Drexl, M., Foeller, E., Vater, M., Kössl, M. J. Neurosci. (2003) [Pubmed]
Inhibitory effect of erythromycin on ion transport by stria vascularis and vestibular dark cells. Liu, J., Marcus, D.C., Kobayashi, T. Acta Otolaryngol. (1996) [Pubmed]
Effects of perilymphatic perfusion with neomycin on the cochlear microphonic potential in the guinea pig. Nuttall, A.L., Marques, D.M., Lawrence, M. Acta Otolaryngol. (1977) [Pubmed]
Gentamicin ototoxicity dissociated from glucose uptake and utilization. Takada, A., Canlon, B., Schacht, J. Res. Commun. Chem. Pathol. Pharmacol. (1983) [Pubmed]

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