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Chemical Compound Review

AC1L2HXG     (2S)-6-amino-2-[[(2S)-6- amino-2-[[(2S)-2,6...

Synonyms: CTK8D1495, AR-1J3323, 2olb, 13184-14-0, 25988-63-0, ...
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Disease relevance of AIDS003578


High impact information on AIDS003578

  • (There is an obvious trade-off between transducer sensitivity, which affects noise and drift and compliance.) Some success has been reported with the use of intact rat myocytes supported by suction micropipettes and in guinea pig ventricular myocytes adhering to poly-L-lysine-coated glass beams [5].
  • Adhesion of HUVEC to fibronectin, but not to poly-L-lysine, rapidly activated ERK1/2 [6].
  • A DNA carrier, consisting of the Fab portion of polyclonal antibodies raised against rat secretory component covalently linked to poly-L-lysine, was used to introduce plasmids containing different reporter genes into airway epithelial cells in vivo [7].
  • Our results demonstrate that MBP and poly-L-lysine activate kallikrein and stimulate the generation of i-kinins in vivo, an effect that may be related to the cationic charge of these proteins [8].
  • Both MBP and poly-L-lysine induced a three- and eightfold increase in levels of kallikrein-like activity and i-kinins, respectively [8].

Chemical compound and disease context of AIDS003578


Biological context of AIDS003578


Anatomical context of AIDS003578

  • Lymphocytes from CLL patients had significantly higher agglutination with PLL than did normal lymphocytes [19].
  • Immunocytochemistry on poly-L-lysine-coated slides was optimised to permit unequivocal identification of a single carcinoma cell in 1 mL of cerebrospinal fluid, as well as carcinoma cell-derived apoptotic bodies that themselves contribute to enhanced diagnostic sensitivity [20].
  • When neurons from early postnatal mouse cerebellum were maintained on laminin or poly-L-lysine, neurite outgrowth was inhibited by oligomannosidic glycans, by glycopeptides, glycoproteins, or neoglycolipids containing oligomannosidic glycans, but not by nonrelated oligosaccharides or oligosaccharide derivates [21].
  • The gold probes, coupled to short poly-L-lysine molecules (4 kD) displayed Brownian motion, with a diffusion coefficient in the range 0.1-0.2 micron2/s. A diffusion coefficient in the 0.1 micron2/s range was also observed with 40-nm gold probes coupled to an antibody against the lipid-linked Thy-1 antigen on 3T3 fibroblasts [22].
  • After successful target interactions, growth cones typically moved off highly adhesive poly-L-lysine substrates into native target cell surfaces [23].

Associations of AIDS003578 with other chemical compounds


Gene context of AIDS003578

  • ERK activation was partially restored by incubating cells plated on poly-l-lysine with collagen-coated beads before IL-1 stimulation [29].
  • In contrast, nonspecific adhesion to poly-L-lysine was ineffective in inducing COX-2 expression [30].
  • Cells on poly-L-lysine or cells in suspension did not exhibit co-distribution of pp125fak, IL-1 receptor, and focal adhesion proteins and did not exhibit calcium flux [31].
  • Poly-l-lysine, a PI(4,5)P(2) scavenger, caused rapid desensitization, whereas MgATP, at concentrations that activate lipid kinases, promoted recovery of TRPM4 currents [32].
  • The NK cell hyporesponsiveness induced in the spleen by MVE-2 was also reversed by a single administration of IFN or polyinosinic-polycytidylic and poly-L-lysine solubilized by carboxymethyl cellulose but not by OK-432 or P. acnes [33].

Analytical, diagnostic and therapeutic context of AIDS003578


  1. Targeted transfection and expression of hepatitis B viral DNA in human hepatoma cells. Liang, T.J., Makdisi, W.J., Sun, S., Hasegawa, K., Zhang, Y., Wands, J.R., Wu, C.H., Wu, G.Y. J. Clin. Invest. (1993) [Pubmed]
  2. Induction of differentiation of Friend murine erythroleukemia cells by poly-L-lysine and daunorubicin-poly-L-lysine conjugate. Supino, R., Gibelli, N., Zunino, F. J. Natl. Cancer Inst. (1986) [Pubmed]
  3. Novel adenovirus component system that transfects cultured cardiac cells with high efficiency. Kohout, T.A., O'Brian, J.J., Gaa, S.T., Lederer, W.J., Rogers, T.B. Circ. Res. (1996) [Pubmed]
  4. Immunocytochemical identification of meningeal leukemia and lymphoma: poly-L-lysine-coated slides permit multimarker analysis even with minute cerebrospinal fluid cell specimens. Kranz, B.R., Thiel, E., Thierfelder, S. Blood (1989) [Pubmed]
  5. Mechanical properties of isolated cardiac myocytes. Brady, A.J. Physiol. Rev. (1991) [Pubmed]
  6. Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase. Takahashi, M., Berk, B.C. J. Clin. Invest. (1996) [Pubmed]
  7. Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor. Ferkol, T., Perales, J.C., Eckman, E., Kaetzel, C.S., Hanson, R.W., Davis, P.B. J. Clin. Invest. (1995) [Pubmed]
  8. Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation. Coyle, A.J., Ackerman, S.J., Burch, R., Proud, D., Irvin, C.G. J. Clin. Invest. (1995) [Pubmed]
  9. Phase II trial of a complex polyriboinosinic-polyribocytidylic acid with poly-L-lysine and carboxymethyl cellulose in the treatment of children with acute leukemia and neuroblastoma: a report from the Children's Cancer Study Group. Lampkin, B.C., Levine, A.S., Levy, H., Krivit, W., Hammond, D. Cancer Res. (1985) [Pubmed]
  10. Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer. Hamblin, M.R., Miller, J.L., Rizvi, I., Ortel, B., Maytin, E.V., Hasan, T. Cancer Res. (2001) [Pubmed]
  11. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer, K.L., Contessa, J., Brenz-Verca, S., Pirola, L., Rusconi, S., Cooper, G., Abo, A., Wymann, M.P., Davis, R.J., Birrer, M., Dent, P. Mol. Biol. Cell (1998) [Pubmed]
  12. Cationic polymer and lipids enhance adenovirus-mediated gene transfer to rabbit carotid artery. Toyoda, K., Ooboshi, H., Chu, Y., Fasbender, A., Davidson, B.L., Welsh, M.J., Heistad, D.D. Stroke (1998) [Pubmed]
  13. Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression. Gottschalk, S., Cristiano, R.J., Smith, L.C., Woo, S.L. Gene Ther. (1994) [Pubmed]
  14. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. Chang, D.D., Wong, C., Smith, H., Liu, J. J. Cell Biol. (1997) [Pubmed]
  15. Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner. Toyoshima, F., Nishida, E. EMBO J. (2007) [Pubmed]
  16. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. Wang, W.J., Kuo, J.C., Yao, C.C., Chen, R.H. J. Cell Biol. (2002) [Pubmed]
  17. Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. Maeda, N., Noda, M. J. Cell Biol. (1998) [Pubmed]
  18. Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival. Astier, A.L., Xu, R., Svoboda, M., Hinds, E., Munoz, O., de Beaumont, R., Crean, C.D., Gabig, T., Freedman, A.S. Blood (2003) [Pubmed]
  19. Surface charge characteristics of peripheral blood lymphocytes in chronic lymphatic leukemia and malignant lymphoma. Marikovsky, Y., Resnitzky, P., Reichman, N. J. Natl. Cancer Inst. (1978) [Pubmed]
  20. Detection of rare malignant cells and their apoptotic fragments in cerebrospinal fluid. Kranz, B.R. Lancet (2000) [Pubmed]
  21. The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with L1 and neurite outgrowth. Horstkorte, R., Schachner, M., Magyar, J.P., Vorherr, T., Schmitz, B. J. Cell Biol. (1993) [Pubmed]
  22. Lateral diffusion and retrograde movements of individual cell surface components on single motile cells observed with Nanovid microscopy. de Brabander, M., Nuydens, R., Ishihara, A., Holifield, B., Jacobson, K., Geerts, H. J. Cell Biol. (1991) [Pubmed]
  23. Cytoskeletal remodeling during growth cone-target interactions. Lin, C.H., Forscher, P. J. Cell Biol. (1993) [Pubmed]
  24. Protamine sulfate inhibition of serum-induced mitogenic responses: differential effects on normal and neoplastic cells. Leibovich, S.J., Polverini, P.J. J. Natl. Cancer Inst. (1984) [Pubmed]
  25. Accumulation of the isolated carboxy-terminal domain of histone H1 in the Xenopus oocyte nucleus. Dingwall, C., Allan, J. EMBO J. (1984) [Pubmed]
  26. Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors. Sundberg, C., Rubin, K. J. Cell Biol. (1996) [Pubmed]
  27. Differential labeling of the cell surface of single ciliary ganglion neurons in vitro. Wessells, N.K., Nuttall, R.P., Wrenn, J.T., Johnson, S. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  28. Polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose in combination with interleukin 2 in patients with cancer: clinical and immunological effects. Ewel, C.H., Urba, W.J., Kopp, W.C., Smith, J.W., Steis, R.G., Rossio, J.L., Longo, D.L., Jones, M.J., Alvord, W.G., Pinsky, C.M. Cancer Res. (1992) [Pubmed]
  29. The recruitment of the interleukin-1 (IL-1) receptor-associated kinase (IRAK) into focal adhesion complexes is required for IL-1beta -induced ERK activation. MacGillivray, M.K., Cruz, T.F., McCulloch, C.A. J. Biol. Chem. (2000) [Pubmed]
  30. Integrin-mediated adhesion and soluble ligand binding stabilize COX-2 protein levels in endothelial cells by inducing expression and preventing degradation. Zaric, J., Rüegg, C. J. Biol. Chem. (2005) [Pubmed]
  31. Interleukin-1-induced calcium flux in human fibroblasts is mediated through focal adhesions. Arora, P.D., Ma, J., Min, W., Cruz, T., McCulloch, C.A. J. Biol. Chem. (1995) [Pubmed]
  32. Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. Zhang, Z., Okawa, H., Wang, Y., Liman, E.R. J. Biol. Chem. (2005) [Pubmed]
  33. Hyporesponsiveness to augmentation of murine natural killer cell activity in different anatomical compartments by multiple injections of various immunomodulators including recombinant interferons and interleukin 2. Talmadge, J.E., Herberman, R.B., Chirigos, M.A., Maluish, A.E., Schneider, M.A., Adams, J.S., Philips, H., Thurman, G.B., Varesio, L., Long, C. J. Immunol. (1985) [Pubmed]
  34. A specific population of gonadotrophs purified from immature female rat pituitary. Denef, C., Hautekeete, E., Rubin, L. Science (1976) [Pubmed]
  35. Oriented adsorption of purple membrane to cationic surfaces. Fisher, K.A., Yanagimoto, K., Stoeckenius, W. J. Cell Biol. (1978) [Pubmed]
  36. Electronic detection of DNA by its intrinsic molecular charge. Fritz, J., Cooper, E.B., Gaudet, S., Sorger, P.K., Manalis, S.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  37. Cell-free tumor antigen peptide-based cancer vaccines. Schmidt, W., Buschle, M., Zauner, W., Kirlappos, H., Mechtler, K., Trska, B., Birnstiel, M.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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