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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cytotoxicity of natural ginseng glycosides and semisynthetic analogues.

The cytotoxicity of natural glycosides from Ginseng, semisynthetic analogues and related triterpenes of the dammarane series, isolated from the leaves of the Far-East species of the genus Betula was studied in order to elucidate structure-activity relationships. Some of the compounds studied were active against the human lung carcinoma GLC4 and adenocarcinoma COLO 320 cell lines. The natural glycosides displayed the lowest cytotoxicity. The triterpenes of the dammarane series used as starting aglycones for semisynthetic derivatives were moderately cytotoxic. The dammarane triterpenes possessing keto groups and their semisynthetic glucosides were the most active compounds tested. Cytotoxic effects of the dammarane glucosides were inversely proportional both to the number of sugars attached to the aglycones and to the number of hydroxy groups of the aglycones. The type of side chain and the configuration of the hydroxy group at C-3 in aglycones did not have a significant influence on the cytotoxicity.[1]


  1. Cytotoxicity of natural ginseng glycosides and semisynthetic analogues. Atopkina, L.N., Malinovskaya, G.V., Elyakov, G.B., Uvarova, N.I., Woerdenbag, H.J., Koulman, A., Pras, N., Potier, P. Planta Med. (1999) [Pubmed]
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