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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.

As in the development of many human cancers, in a transgenic mouse model of beta-cell carcinogenesis (Rip1Tag2), expression of neural cell adhesion molecule (NCAM) changes from the 120-kDa isoform in normal tissue to the 140/180-kDa isoforms in tumors. NCAM-deficient RiplTag2 mice, generated by crossing Rip1Tag2 mice with NCAM knockout mice, develop metastases, a tumor stage that is not seen in normal Rip1Tag2 mice. In contrast, overexpression of NCAM 120 in NCAM-deficient Rip1Tag2 mice prevents tumor metastasis. The results indicate that the loss of NCAM-mediated cell adhesion is one rate-limiting step in the actual metastatic dissemination of beta tumor cells.[1]

References

  1. Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Perl, A.K., Dahl, U., Wilgenbus, P., Cremer, H., Semb, H., Christofori, G. Nat. Med. (1999) [Pubmed]
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