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Gene Review

Ncam1  -  neural cell adhesion molecule 1

Mus musculus

Synonyms: CD56, E-NCAM, N-CAM-1, NCAM, NCAM-1, ...
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Disease relevance of Ncam1


Psychiatry related information on Ncam1


High impact information on Ncam1


Chemical compound and disease context of Ncam1


Biological context of Ncam1


Anatomical context of Ncam1

  • In the present study, we focused on two genes, Car2 and Ncam1, which both exhibited increased expression in interspecies and cloned hyperplastic placentas [1].
  • PC12 cells were cultured on monolayers of control 3T3 cells or 3T3 cells expressing transfected N-cadherin or NCAM [10].
  • FGF ligands can replace N-CAM in promoting matrix adhesion but not neurite outgrowth [2].
  • Primary chicken embryo liver cells, which aggregate primarily by calcium-dependent adhesion mechanisms, did not show changes in the N-CAM gene or in the other genes whose transcription rates changed in CEB cells and P19 cells [3].
  • In an effort to determine whether homeobox genes modulate the activity of the promoter of the mouse neural cell adhesion molecule (N-CAM) gene, we have carried out a series of cotransfection experiments using NIH 3T3 cells [18].

Associations of Ncam1 with chemical compounds


Physical interactions of Ncam1

  • Additionally, similar levels of PrP/N-CAM complexes were found in N2a and prion-infected N2a (ScN2a) cells [5].
  • These results are consistent with our results showing that HNK-1 glycan is minimally attached to O-glycans of NCAM in fetal brain, heart, and the myoblast cell line, C2C12 [23].

Co-localisations of Ncam1


Regulatory relationships of Ncam1


Other interactions of Ncam1

  • Dominant-negative FGFR-4, inhibitors of FGFR signalling and anti-beta(1)-integrin antibodies repress matrix adhesion induced by N-CAM [2].
  • Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth [28].
  • This result suggests an additional linkage between Ncam and the locus for the cerebellar mutation staggerer (sg) [4].
  • Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4 [18].
  • Contrary to NCAM mutant mice, LTP in ST8SiaIV mutants was undisturbed at mossy fiber-CA3 synapses, which do not express PSA in wild-type mice [29].

Analytical, diagnostic and therapeutic context of Ncam1


  1. Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1. Singh, U., Sun, T., Shi, W., Schulz, R., Nuber, U.A., Varanou, A., Hemberger, M.C., Elliott, R.W., Ohta, H., Wakayama, T., Fundele, R. Dev. Dyn. (2005) [Pubmed]
  2. N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Cavallaro, U., Niedermeyer, J., Fuxa, M., Christofori, G. Nat. Cell Biol. (2001) [Pubmed]
  3. Cell adhesion alters gene transcription in chicken embryo brain cells and mouse embryonal carcinoma cells. Mauro, V.P., Wood, I.C., Krushel, L., Crossin, K.L., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. Chromosomal location of the gene encoding the neural cell adhesion molecule (N-CAM) in the mouse. D'Eustachio, P., Owens, G.C., Edelman, G.M., Cunningham, B.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  5. Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. Schmitt-Ulms, G., Legname, G., Baldwin, M.A., Ball, H.L., Bradon, N., Bosque, P.J., Crossin, K.L., Edelman, G.M., DeArmond, S.J., Cohen, F.E., Prusiner, S.B. J. Mol. Biol. (2001) [Pubmed]
  6. Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. Stork, O., Welzl, H., Wotjak, C.T., Hoyer, D., Delling, M., Cremer, H., Schachner, M. J. Neurobiol. (1999) [Pubmed]
  7. Neural cell adhesion molecule (NCAM) null mice do not show a deficit in odour discrimination learning. Schellinck, H.M., Arnold, A., Rafuse, V.F. Behav. Brain Res. (2004) [Pubmed]
  8. Kv1.1 channel antisense attenuates learning and modulation of dentate polysialylated NCAM. Gratacós, E., Ghelardini, C., Gherardini, L.M., Galeotti, N., Murphy, K.J., Bartolini, A., Regan, C.M. Neuroreport (1998) [Pubmed]
  9. Altered expression of polysialylated NCAM in mouse hippocampus following trimethyltin administration. Dey, P.M., Polunas, M.A., Philbert, M.A., Reuhl, K.R. Neurotoxicology (1997) [Pubmed]
  10. Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels. Doherty, P., Ashton, S.V., Moore, S.E., Walsh, F.S. Cell (1991) [Pubmed]
  11. Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Windrem, M.S., Nunes, M.C., Rashbaum, W.K., Schwartz, T.H., Goodman, R.A., McKhann, G., Roy, N.S., Goldman, S.A. Nat. Med. (2004) [Pubmed]
  12. Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Perl, A.K., Dahl, U., Wilgenbus, P., Cremer, H., Semb, H., Christofori, G. Nat. Med. (1999) [Pubmed]
  13. LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats. Zhang, J.S., Longo, F.M. J. Cell Biol. (1995) [Pubmed]
  14. Colonization of human lung grafts in SCID-hu mice by human colon carcinoma cells. Sampson-Johannes, A., Wang, W., Shtivelman, E. Int. J. Cancer (1996) [Pubmed]
  15. Selective expression of the 180-kD component of the neural cell adhesion molecule N-CAM during development. Pollerberg, E.G., Sadoul, R., Goridis, C., Schachner, M. J. Cell Biol. (1985) [Pubmed]
  16. Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180. Stork, O., Welzl, H., Wolfer, D., Schuster, T., Mantei, N., Stork, S., Hoyer, D., Lipp, H., Obata, K., Schachner, M. Eur. J. Neurosci. (2000) [Pubmed]
  17. Localization of the human NCAM gene to band q23 of chromosome 11: the third gene coding for a cell interaction molecule mapped to the distal portion of the long arm of chromosome 11. Nguyen, C., Mattei, M.G., Mattei, J.F., Santoni, M.J., Goridis, C., Jordan, B.R. J. Cell Biol. (1986) [Pubmed]
  18. Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4. Jones, F.S., Prediger, E.A., Bittner, D.A., De Robertis, E.M., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  19. In vitro oligodendrogliotrophic properties of cell adhesion molecules in the immunoglobulin superfamily: myelin-associated glycoprotein and N-CAM. Gard, A.L., Maughon, R.H., Schachner, M. J. Neurosci. Res. (1996) [Pubmed]
  20. In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid. Stoenica, L., Senkov, O., Gerardy-Schahn, R., Weinhold, B., Schachner, M., Dityatev, A. Eur. J. Neurosci. (2006) [Pubmed]
  21. Cellular and molecular analysis of neural development of glycosyltransferase gene knockout mice. Angata, K., Lee, W., Mitoma, J., Marth, J.D., Fukuda, M. Meth. Enzymol. (2006) [Pubmed]
  22. Changes in sialylation in homozygous Sp2H mouse mutant embryos. Glogarová, K., Buckiová, D. Birth defects research. Part A, Clinical and molecular teratology. (2004) [Pubmed]
  23. Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM. Ong, E., Suzuki, M., Belot, F., Yeh, J.C., Franceschini, I., Angata, K., Hindsgaul, O., Fukuda, M. J. Biol. Chem. (2002) [Pubmed]
  24. Expression pattern of M-cadherin in normal, denervated, and regenerating mouse muscles. Irintchev, A., Zeschnigk, M., Starzinski-Powitz, A., Wernig, A. Dev. Dyn. (1994) [Pubmed]
  25. P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Mirnics, Z.K., Yan, C., Portugal, C., Kim, T.W., Saragovi, H.U., Sisodia, S.S., Mirnics, K., Schor, N.F. Neurobiol. Dis. (2005) [Pubmed]
  26. The mouse homeodomain protein OTX2 regulates NCAM promoter activity. Nguyen Ba-Charvet, K.T., von Boxberg, Y., Godement, P. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  27. Hypothyroidism prolongs and increases mdx muscle precursor proliferation and delays myotube formation in normal and dystrophic limb muscle. McIntosh, L.M., Anderson, J.E. Biochem. Cell Biol. (1995) [Pubmed]
  28. Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. Santuccione, A., Sytnyk, V., Leshchyns'ka, I., Schachner, M. J. Cell Biol. (2005) [Pubmed]
  29. Mice deficient in the polysialyltransferase ST8SiaIV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity. Eckhardt, M., Bukalo, O., Chazal, G., Wang, L., Goridis, C., Schachner, M., Gerardy-Schahn, R., Cremer, H., Dityatev, A. J. Neurosci. (2000) [Pubmed]
  30. Selective loss of the 180-kDa form of the neural cell adhesion molecule in hippocampus and cerebellum of the adult mouse following trimethyltin administration. Dey, P.M., Graff, R.D., Lagunowich, L.A., Reuhl, K.R. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  31. Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1. Kulahin, N., Kasper, C., Gajhede, M., Berezin, V., Bock, E., Kastrup, J.S. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  32. Patterns of hair cell survival and innervation in the cochlea of the bronx waltzer mouse. Whitlon, D.S., Sobkowicz, H.M. J. Neurocytol. (1991) [Pubmed]
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