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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Confluent ecchymoses on the lower extremities of a malnourished patient.

Nutritional deficiencies result in many distinctive cutaneous manifestations. Vitamin C deficiency, or scurvy, produces follicular hyperkeratosis, perifollicular hemorrhages, gingival hypertrophy, and bleeding (1). We report here a case of malnutrition who suddenly developed extensive eccymoses on the lower extremities sharing morphological similarities with purpura fulminans. Although the patient did not have the characteristic dermatological features of scurvy, serum levels of vitamins C, K, B12, and E were decreased.[1]


  1. Confluent ecchymoses on the lower extremities of a malnourished patient. Sasaki, G., Satoh, T., Yokozeki, H., Katayama, I., Nishioka, K. J. Dermatol. (1999) [Pubmed]
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